Wyniki wyszukiwania dla: GLUTATHIONE S-CONJUGATE

• The influence of road transport on the activities of glutathione reductase, glutathione peroxidase, and glutathione-S-transferase in equine erythrocytes

  Publikacja

  • A. Niedźwiedź
  • J. Nicpoń
  • M. Zawadzki
  • M. Służewska-Niedźwiedź
  • L. Januszewska

  - VETERINARY CLINICAL PATHOLOGY - Rok 2012

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• Ecological Chemistry and Engineering S - Chemia i Inżynieria Ekologiczna S

  Czasopisma

  ISSN: 1898-6196 , eISSN: 2084-4549

• Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions

  Publikacja

  • A. Potęga
  • M. Kosno
  • Z. Mazerska

  - Journal of Pharmaceutical Analysis - Rok 2021

  Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-mediated metabolic pathway of a representative UA, C 2028. GSH supplemented incubations of C-2028 with rat, but not with human, liver...

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• In vitro enzyme kinetics and NMR-based product elucidation for glutathione S-conjugation of the anticancer unsymmetrical bisacridine C-2028 in liver microsomes and cytosol: major role of glutathione S-transferase M1-1 isoenzyme

  Publikacja

  • A. Potęga
  • D. Rafalska
  • D. Kazimierczyk
  • M. Kosno
  • A. Pawłowicz
  • W. Andrałojć
  • E. Paluszkiewicz
  • T. Laskowski

  - MOLECULES - Rok 2023

  This work is the next step in studying the interplay between C-2028 (anticancer-active unsymmetrical bisacridine developed in our group) and the glutathione S-transferase/glutathione (GST/GSH) system. Here, we analyzed the concentration- and pH-dependent GSH conjugation of C-2028 in rat liver microsomes and cytosol. We also applied three recombinant human GST isoenzymes, which altered expression was found in various tumors. The...

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• Involvement of human glutathione S-transferase M1-1 in the glutathione conjugation of the antitumor unsymmetrical bisacridine derivative C-2028.

  Dane Badawcze

  open access

  • A. Potęga
  • A. Mierzejewska
  • J. Pasztelan
  • K. Kozłowska-Tylingo

  Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. The aim of this study was to investigate the possible role of human glutathione S-transferase M1-1 (hGSTM1-1) in the glutathione (GSH) conjugation of a representative UA, C‑2028.

• Ascorbate and glutathione metabolism in embryo axes and cotyledons of germinating lupine seeds

  Publikacja

  • M. Garnczarska
  • Ł. Wojtyla

  - BIOLOGIA PLANTARUM - Rok 2008

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• Feminismo/s

  Czasopisma

  ISSN: 1696-8166

• Bresil-s

  Czasopisma

  ISSN: 2257-0543 , eISSN: 2425-231X

• Feminismo-s

  Czasopisma

  eISSN: 1989-9998

• Parlement[s]

  Czasopisma

  ISSN: 1768-6520