Wyniki wyszukiwania dla: PYROGLUTAMIC ACID

• AMINO ACIDS

  Czasopisma

  ISSN: 0939-4451 , eISSN: 1438-2199

• NUCLEIC ACIDS RESEARCH

  Czasopisma

  ISSN: 0305-1048 , eISSN: 1362-4962

• Nucleic Acid Therapeutics

  Czasopisma

  ISSN: 2159-3337 , eISSN: 2159-3345

• Arid Ecosystems

  Czasopisma

  ISSN: 2079-0961 , eISSN: 2079-0988

• Immunosuppressive properties of amino acid and peptide derivatives of mycophenolic acid

  Publikacja

  • A. Siebert
  • G. Cholewiński
  • P. Trzonkowski
  • J. Rachoń

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Rok 2020

  Mycophenolic acid (MPA) was coupled with amino acids and biologically active peptides including derivatives of tuftsin to modify its immunosuppressive properties. Both amino acid unit in the case of simple MPA amides and modifications within peptide moiety of MPA - tuftsin conjugates influenced the observed activity. Antiproliferative potential of the obtained conjugates was investigated in vitro and MPA amides with threonine methyl...

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• Synthesis and biological activity of mycophenolic acid-amino acid derivatives

  Publikacja

  • D. Iwaszkiewicz-Grzes
  • G. Cholewinski
  • A. Kot-Wasik
  • P. Trzonkowski
  • K. Dzierzbicka

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Rok 2013

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• Synthesis and biological activity of mycophenolic acid-amino acid derivatives

  Publikacja

  • D. Iwaszkiewicz-Grześ
  • G. Cholewiński
  • A. Kot-Wasik
  • P. Trzonkowski
  • K. Dzierzbicka

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Rok 2013

  In search of new immunosuppressants, mycophenolic acid (MPA) was coupled with amino acid methyl esters followed by hydrolysis to analogs bearing free carboxylic groups. The obtained compunds were tested in vitro as growth inhibitors of lymphoid cell line (Jurkat) and human peripheral blood mononuclear cells (PBMC) from healthy donors. According to obtained results recovering of free carboxylic group increased their activity. Additionally,...

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• Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid

  Publikacja

  • A. Siebert
  • M. Deptuła
  • M. Cichorek
  • A. Ronowska
  • G. Cholewiński
  • J. Rachoń

  - Anti-Cancer Agents in Medicinal Chemistry - Rok 2021

  Background: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...

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• Hyaluronic acid/tannic acid films for wound healing application

  Publikacja

  • M. Wekwejt
  • M. Małek
  • A. Ronowska
  • A. Michno
  • A. Pałubicka
  • A. Klimek
  • B. Kaczmarek-Szczepańska

  - INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES - Rok 2024

  In this study, thin films based on hyaluronic acid (HA) with tannic acid (TA) were investigated in three different weight ratios (80HA/20TA, 50HA/50TA, 20HA/80TA) for their application as materials for wound healing. Surface free energy, as well as their roughness, mechanical properties, water vapor permeability rate, and antioxidant activity were determined. Moreover, their compatibility with blood and osteoblast cells was investigated....

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• ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT

  Czasopisma

  ISSN: 1087-2906