Wyniki wyszukiwania dla: REGENERATIVE DRUGS

• Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration

  Publikacja

  • P. Sosnowski

  - Rok 2021

  Despite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...

• Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

  Publikacja

  • P. Sosnowski
  • P. Sass
  • P. Słonimska
  • R. Płatek
  • J. Kamińska
  • J. Baczyński-Keller
  • P. Mucha
  • G. Peszyńska-Sularz
  • A. Czupryn
  • M. Pikuła... i 5 innych

  - Pharmaceuticals - Rok 2022

  The ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...

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• Disposition of Drugs of Abuse and Their Metabolites in Wastewater as a Method of the Estimation of Drug Consumption

  Publikacja

  • E. Daghir
  • M. J.

  - Current Drug Metabolism - Rok 2010

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• Methods for Elucidation of DNA-Anticancer Drug Interactions and Their Applications in the Development of New Drugs

  Publikacja

  • M. Misiak
  • F. Mantegazza
  • G. Beretta

  - CURRENT PHARMACEUTICAL DESIGN - Rok 2016

  DNA damaging agents including anthracyclines, camptothecins and platinum drugs are among most frequently used drugs in the chemotherapeutic routine. Due to their relatively low selectivity for cancer cells, administration is associated with adverse side effects, whereas the inherent genotoxicity of these drugs is associated with risk of developing secondary cancers. Development of new drugs, which could be spared of these drawbacks...

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• Regenerative Therapy

  Czasopisma

  ISSN: 2352-3204

• Regenerative Biomaterials

  Czasopisma

  ISSN: 2056-3418 , eISSN: 2056-3426

• Regenerative Medicine

  Czasopisma

  ISSN: 1746-0751 , eISSN: 1746-076X

• From Regenerative Buildings to Regenerative Urban Projects: Design frameworks to scale up within the area of regenerative practice

  Publikacja

  • E. Blanco
  • D. D. Kamrowska-Załuska
  • J. Gremmelspacher
  • M. Orova

  - Rok 2021

  In this chapter, a discussion will be presented of design frameworks and assessment tools that are useful for boosting the scale jumping of regenerative design practices and the paradigm shift. Our main objectives will be to identify existing design and assessment frameworks, to describe the way they work and how they can contribute to scale-jumping regenerative design, as well as to identify shortcomings and opportunities. We...

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• Regeneration

  Czasopisma

  ISSN: 2052-4412

• Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.

  Publikacja

  • A. Potęga

  - MOLECULES - Rok 2022

  The effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...

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