Wyniki wyszukiwania dla: benzohydroxamic acid

• Cytotoxic and Antioxidant Activities of Benzohydroxamic Acid Analogues

  Publikacja

  • W. Przychodzeń
  • J. Nycz

  - BULLETIN OF THE KOREAN CHEMICAL SOCIETY - Rok 2013

  20 benzohydroxamic acid analogues were synthesized and evaluated for their in vitro cytotoxicities against mouse mammary tumor cells as well as antioxidant activities against DPPH radical and superoxide anion. It was found that benzothiohydroxamic acids exhibit greater cytotoxicities than benzohydroxamic acids and N-isopropyl derivatives are more active than N-methyl ones. On the other hand, benzothiohydroxamic acids show more...

  Pełny tekst do pobrania w serwisie zewnętrznym

• Unexpected Z/E isomerism of N-methyl-O-phosphothioyl benzohydroxamic acids, their oxyphilic reactivity and inertness to amines

  Publikacja

  • A. Majewski
  • J. Chojnacki
  • W. Przychodzeń

  - STRUCTURAL CHEMISTRY - Rok 2021

  Thiophosphinoylation of N-methyl p-substituted benzohydroxamic acids using disulfanes (method A) or diphenylphosphinothioyl chloride (method B) provides only one conformer of the respective O-phosphothioyl derivative (Xray and NMR analysis). Undergoing the P-transamidoxylation reaction is an evidence of the reversibility of thiophosphinoylation. Only those products containing strong EWG substituents in the aroyl residue or bulky...

  Pełny tekst do pobrania w portalu

• AMINO ACIDS

  Czasopisma

  ISSN: 0939-4451 , eISSN: 1438-2199

• NUCLEIC ACIDS RESEARCH

  Czasopisma

  ISSN: 0305-1048 , eISSN: 1362-4962

• Nucleic Acid Therapeutics

  Czasopisma

  ISSN: 2159-3337 , eISSN: 2159-3345

• Matcha Green Tea: Chemical Composition, Phenolic Acids, Caffeine and Fatty Acid Profile

  Publikacja

  • J. Kika
  • K. Jakubczyk
  • A. Ligenza
  • D. Maciejewska-Markiewicz
  • K. Szymczykowska
  • K. Janda-Milczarek

  - Foods - Rok 2024

  Pełny tekst do pobrania w serwisie zewnętrznym

• Arid Ecosystems

  Czasopisma

  ISSN: 2079-0961 , eISSN: 2079-0988

• Synthesis and biological activity of mycophenolic acid-amino acid derivatives

  Publikacja

  • D. Iwaszkiewicz-Grzes
  • G. Cholewinski
  • A. Kot-Wasik
  • P. Trzonkowski
  • K. Dzierzbicka

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Rok 2013

  Pełny tekst do pobrania w serwisie zewnętrznym

• Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid

  Publikacja

  • A. Siebert
  • M. Deptuła
  • M. Cichorek
  • A. Ronowska
  • G. Cholewiński
  • J. Rachoń

  - Anti-Cancer Agents in Medicinal Chemistry - Rok 2021

  Background: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...

  Pełny tekst do pobrania w portalu

• Immunosuppressive properties of amino acid and peptide derivatives of mycophenolic acid

  Publikacja

  • A. Siebert
  • G. Cholewiński
  • P. Trzonkowski
  • J. Rachoń

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Rok 2020

  Mycophenolic acid (MPA) was coupled with amino acids and biologically active peptides including derivatives of tuftsin to modify its immunosuppressive properties. Both amino acid unit in the case of simple MPA amides and modifications within peptide moiety of MPA - tuftsin conjugates influenced the observed activity. Antiproliferative potential of the obtained conjugates was investigated in vitro and MPA amides with threonine methyl...

  Pełny tekst do pobrania w portalu