Wyniki wyszukiwania dla: drugs dosage

• Disposition of Drugs of Abuse and Their Metabolites in Wastewater as a Method of the Estimation of Drug Consumption

  Publikacja

  • E. Daghir
  • M. J.

  - Current Drug Metabolism - Rok 2010

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• Methods for Elucidation of DNA-Anticancer Drug Interactions and Their Applications in the Development of New Drugs

  Publikacja

  • M. Misiak
  • F. Mantegazza
  • G. Beretta

  - CURRENT PHARMACEUTICAL DESIGN - Rok 2016

  DNA damaging agents including anthracyclines, camptothecins and platinum drugs are among most frequently used drugs in the chemotherapeutic routine. Due to their relatively low selectivity for cancer cells, administration is associated with adverse side effects, whereas the inherent genotoxicity of these drugs is associated with risk of developing secondary cancers. Development of new drugs, which could be spared of these drawbacks...

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• Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.

  Publikacja

  • A. Potęga

  - MOLECULES - Rok 2022

  The effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...

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• Optical properties of the chemotherapy drugs used in the central nervous system lymphoma therapy: monitoring drug delivery

  Publikacja

  • T. Myllylä
  • A. P. Popov
  • Ł. Surażyński
  • J. Oinas
  • O. Bibikova
  • A. Bykov
  • M. Wróbel
  • M. Gnyba
  • M. Szczerska
  • I. Meglinski
  • O. Kuittinen

  - Rok 2015

  Our aim is to optically monitor the delivery of the chemotherapy drugs for brain tumours, particularly used in the central nervous system (CNS) lymphoma therapy. In vivo monitoring would help to optimize the treatment and avoiding unnecessary medications. Moreover, it would be beneficial to be able to measure which of the multi-regimen drugs actually do penetrate and how well into the brain tissue. There exist several potential...

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• Drugs and driving

  Publikacja

  • J. Staniszewski
  • W. Kustra

  - Rok 2007

  W referacie przedstawiono we wprowadzeniu pojawienie się nowego zagrożenia, jakim jest kierowanie pojazdów przez osoby będące pod wpływek narkotyków. W drugiej części przedstawiono obecnie obowiązujące sankcje, jakie mogą spotkać kierującego oraz definicję środków odurzających, po zażyciu których nie można prowadzić samochodu. W trzeciej części przedstawiono badania naukowe przeprowadzone w Polsce i Niemczech, które pokazują jak...

• Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs

  Publikacja

  • K. Wojtowicz
  • K. Sterzyńska
  • M. Świerczewska
  • M. Nowicki
  • M. Zabel
  • R. Januchowski

  - International Journal of Molecular Sciences - Rok 2021

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• Antipsychotic drug prescription sequence analysis in relation to death occurrence and cardiometabolic drug usage: A retrospective longitudinal study

  Publikacja

  • P. Zagozdzon
  • P. Dorozynski
  • P. Waszak
  • A. Harasimowicz
  • T. Dziubich

  - EUROPEAN JOURNAL OF PSYCHIATRY - Rok 2023

  The potential role of antipsychotics in increasing cardiovascular risk of mortality is still debated. The aim of this study was to assess the death risk associated with sequences of first-generation antipsychotic (FGA) and second-generation antipsychotic (SGA) prescriptions, including clozapine and lithium, and drugs for cardiometabolic diseases. We conducted a retrospective longitudinal analysis involving 84,881 patients who received...

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• DRUGS

  Czasopisma

  ISSN: 0012-6667 , eISSN: 1179-1950

• International Journal for Parasitology-Drugs and Drug Resistance

  Czasopisma

  ISSN: 2211-3207

• Primary degradation of antidiabetic drugs

  Publikacja

  • M. Markiewicz
  • C. Jungnickel
  • S. Stolte
  • A. Białk-Bielińska
  • J. Kumirska
  • W. Mrozik

  - JOURNAL OF HAZARDOUS MATERIALS - Rok 2017

  Type 2 diabetes is a chronic disease affecting a large portion of the world population and is treated by orally administered drugs. Since these drugs are often taken in high doses and are excreted unchanged or partially metabolised many of them are nowadays detected in surface waters or wastewater treatment plants effluents. Unmetabolised antidiabetics or some of their transformation products retain their pharmacological activity,...

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