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Wyniki wyszukiwania dla: PSORIASIS GENETICS, GWAS, EPIGENETIC CHANGES, MIRNA
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Pathogenesis of psoriasis in the “omic” era. Part II. Genetic, genomic and epigenetic changes in psoriasis
PublikacjaPsoriasis is a multifactorial disease in which genetic, environmental and epigenetic factors regulating gene expression play a key role. In the “genomic era”, genome-wide association studies together with target genotyping platforms performed in different ethnic populations have found more than 50 genetic susceptible markers associated with the risk of psoriasis which have been identified so far. Up till now, the strongest association...
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The hypoxia‐induced changes in miRNA‐mRNA in RNA ‐induced silencing complexes and HIF ‐2 induced miRNAs in human endothelial cells
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mRNA adenosine methylase (MTA) deposits m 6 A on pri-miRNAs to modulate miRNA biogenesis in Arabidopsis thaliana
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Genetics & Epigenetics
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Journal of Psoriasis and Psoriatic Arthritis
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Genetic and Epigenetic Aspects of Atopic Dermatitis
PublikacjaAtopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with mutations in genes encoding epidermal structural proteins, barrier enzymes, and their inhibitors; the role of genes regulating innate and adaptive immune responses and environmental factors inducing the disease is also noted. Recent studies point to the key role of epigenetic changes in the development of the disease. Epigenetic modifications...
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SiMiSnoRNA: Collection of siRNA, miRNA, and snoRNA database for RNA Interference
PublikacjaObjective:The discovery of sequence specific gene silencing which occurs due to the presence of double-stranded RNAs has considerable impact on biology, revealing an unknown level of regulation of gene expression. This process is known as RNA interference (RNAi) or RNA silencing in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecule. Two types of small RNA molecules - small...
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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
PublikacjaSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose...
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Nanosized zinc, epigenetic changes and its relationship with DMBA induced breast cancer in rats
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Epigenetic-Based Therapy—A Prospective Chance for Medulloblastoma Patients’ Recovery
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Ecological Genetics and Genomics
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Journal of Genetics and Genomics
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MOLECULAR GENETICS AND GENOMICS
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Charge Loss in Gas-Phase Multiply Negatively Charged Oligonucleotides
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Recent Insights into Plant miRNA Biogenesis: Multiple Layers of miRNA Level Regulation
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The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family
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Psoriasis-Targets and Therapy
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Changes in Epigenetic Patterns Related to DNA Replication in Vicia faba Root Meristem Cells under Cadmium-Induced Stress Conditions
PublikacjaExperiments on Vicia faba root meristem cells exposed to 150 µM cadmium chloride (CdCl2) were undertaken to analyse epigenetic changes, mainly with respect to DNA replication stress. Histone modifications examined by means of immunofluorescence labeling included: (1) acetylation of histone H3 on lysine 56 (H3K56Ac), involved in transcription, S phase, and response to DNA damage during DNA biosynthesis; (2) dimethylation of histone...
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Psoriasis and cardiometabolic disorders
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Sleep disorders in psoriasis
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The role of lipids in psoriasis
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Human Genetics and Genomics Advances
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The role of epigenetics in regeneration
PublikacjaComplex changes in chromatin structure and at the transcriptional level occur from the creation of a single parental gamete throughout fertilization, embryo development and the life of an adult organism. Epigenetic changes, such as methylation and hydroxymethylation of DNA or histone methylation and acetylation, are an important part of these processes. Epigenetic regulation has an essential influence on gene expression level. DNA...
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Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
PublikacjaPsoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and...
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Models in the Research Process of Psoriasis
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Selected aspects of apoptosis in psoriasis
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Epigenetics & Chromatin
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EPIGENETICS-US
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Epigenetics Insights
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Environmental Epigenetics
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Posttranscriptional coordination of splicing and miRNA biogenesis in plants
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Annual Review of Genomics and Human Genetics
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Aberrations in Lipid Expression and Metabolism in Psoriasis
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Serum irisin levels in patients with psoriasis
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Urinary Measurement of Epigenetic DNA Modifications: A Non-Invasive Assessment of the Whole-Body Epigenetic Status in Healthy Subjects and Colorectal Cancer Patients
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Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging
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JOURNAL OF APPLIED GENETICS
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Jan Domaradzki dr hab.
Osobysocjolog, adiunkt w Katedrze Nauk Społecznych Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu, kierownik Pracowni Socjologii Zdrowia i Patologii Społecznych. Habilitację otrzymałem w roku 2019 w Instytucie Socjologii UAM na podstawie rozprawy: Społeczne konstruowanie genetyki. Reprezentacje biotechnologii w polskim czasopiśmiennictwie opiniotwórczym. Doktorat obroniłem w roku 2008 w Instytucie Socjologii, UKSW na...
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A New Epigenetic Mechanism of Temozolomide Action in Glioma Cells
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A Single Mutation in a Tunnel to the Active Site Changes the Mechanism and Kinetics of Product Release in Haloalkane Dehalogenase LinB*
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The Role of miRNA-7 in the Biology of Cancer and Modulation of Drug Resistance
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Factors affecting response to biologic treatment in psoriasis
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Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis
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GENETICS
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Global DNA demethylation as an epigenetic marker of human brain metastases
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Paweł Huelle, Mina
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Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer
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Epidemiological evaluation of paediatric psoriasis patients at the Dermatology Department
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Secukinumab for the Treatment of Psoriasis in Pediatrics: Patient Selection and Acceptability
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Unbalanced Sphingolipid Metabolism and Its Implications for the Pathogenesis of Psoriasis
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