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Wyniki wyszukiwania dla: SPERMINE NONOATE DETANONOATE NPLA SCHIZOPHRENIA ALZHEIMER'S DISEASE COGNITION
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Procognitive activity of nitric oxide inhibitors and donors in animal models
PublikacjaNitric oxide is a small gaseous molecule that plays important roles in the majority of biological functions. Impairments of NO-related pathways contribute to the majority of neurological disorders, such as Alzheimer’s disease (AD), and mental disorders, such as schizophrenia. Cognitive decline is one of the most serious impairments accompanying both AD and schizophrenia. In the present study, the activities of NO donors, slow (spermine...
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Cognitive Abilities of Alzheimers Disease Transgenic Mice are Modulated by Social Context and Circadian Rhythm
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Schizophrenia Research: Cognition
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Ecological Chemistry and Engineering S - Chemia i Inżynieria Ekologiczna S
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An Overview of Several Inhibitors for Alzheimer’s Disease: Characterization and Failure
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Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia
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ALZHEIMER DISEASE & ASSOCIATED DISORDERS
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Are advanced glycation end-products specific biomarkers for Alzheimer's disease?
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Vitamin D receptor gene polymorphisms in Alzheimer's disease patients
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Journal of Alzheimers Disease Reports
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Analysis of Serum of Patients With Alzheimer’s Disease for the Level of Advanced Glycation End Products
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Investigating the disease‐modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
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Investigating the disease- modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
PublikacjaAlzheimer's disease (AD) is a progressive neurodegenerative disorder caused due to the damage and loss of neurons in specific brain regions. It is the most common form of dementia observed in older people. The symptoms start with memory loss and gradually cause the inability to speak and do day-to-day activities. The cost of caring for those affected individuals is huge and is probably beyond most developing countries capability....
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SYNTHESIS OF PHOSPHORUS TACRINE ANALOGUES AS A NEW POTENTIAL ANTI-ALZHEIMER’S DISEASE AGENTS
PublikacjaA series of novel phosphorus tacrine derivatives was obtained in three steps, including synthesis of 9-chlorotacrine, connection of 9-chlorotacrine with hexamethylenediamine, 1,8-diaminooctane and 1,12-diaminododecane linkers and reaction of obtained tacrine diamine analogues with corresponding acid ester to give nine tacrine organophosphorus compounds. All of the obtained final structures were characterized by 1H NMR, 13C NMR,...
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Fecal Serine Protease Profiling in Inflammatory Bowel Diseases
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Tackling Alzheimer's disease: Hypothetical synergism between anti-inflammatory and anti-diabetic agents
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International Journal of Alzheimer's Disease
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Schizophrenia
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Cognitive decline in Huntington's disease expansion gene carriers
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JPAD-Journal of Prevention of Alzheimers Disease
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Ovocystatin Induced Changes in Expression of Alzheimer’s Disease Relevant Proteins in APP/PS1 Transgenic Mice
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Errorless Learning as a method of neuropsychological rehabilitation of individuals suffering from dementia in the course of Alzheimer’s disease
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Detection of Alzheimer's disease using Otsu thresholding with tunicate swarm algorithm and deep belief network
PublikacjaIntroduction: Alzheimer’s Disease (AD) is a degenerative brain disorder characterized by cognitive and memory dysfunctions. The early detection of AD is necessary to reduce the mortality rate through slowing down its progression. The prevention and detection of AD is the emerging research topic for many researchers. The structural Magnetic Resonance Imaging (sMRI) is an extensively used imaging technique in detection of AD, because...
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Serotonergic–Muscarinic Interaction within the Prefrontal Cortex as a Novel Target to Reverse Schizophrenia-Related Cognitive Symptoms
PublikacjaRecent studies revealed that the activation of serotonergic 5-HT1A and muscarinic M1, M4, or M5 receptors prevent MK-801-induced cognitive impairments in animal models. In the present study, the effectiveness of the simultaneous activation of 5-HT1A and muscarinic receptors at preventing MK-801-induced cognitive deficits in novel object recognition (NOR) or Y-maze tests was investigated. Activators of 5-HT1A (F15599), M1 (VU0357017),...
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Selected mice models based on APP, MAPT and presenilin gene mutations in research on the pathogenesis of Alzheimer’s disease
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Design of new cholinesterase inhibitors based on phosphorus analogs of tacrine as potential anti-Alzheimer’s disease agents
PublikacjaBased on the analysis of the determined free binding energy (using the AutoDock Vina 1.1.2 docking program), the most potent cholinesterase inhibitors were selected. Moreover, studies of 3D visualization of the results of molecular modeling led to the identification of potential sites for the interaction of new potential inhibitors with amino acid residues building active sites of investigated cholinesterases.
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Assessment of the Association Between Cigarette Smoking and Cognitive Performance in Patients With Schizophrenia-Spectrum Disorders: A Case-Control Study
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Unraveling the Protective Effects of Cognitive Reserve on Cognition and Brain: A Cross-Sectional Study
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npj Schizophrenia
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SCHIZOPHRENIA BULLETIN
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Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer’s disease
PublikacjaIn this work, we designed, synthesised and biologically investigated a novel series of 14N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer’s disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoalkylalcohol we obtained diamino and aminoalkylhydroxy tacrine derivatives. Next, the compounds were acid to give final products 6–13 and 16–21 that were characterised by 1H, 13 C, 31P...
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Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
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Abdominal epilepsy in patient of schizophrenia - a diagnostic dilemma
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Gender dysphoria (transsexulism) and schizophrenia: a case report
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Gender dysphoria (transsexulism) and schizophrenia: a case report
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Role of Vitamin D in schizophrenia in elderly patient
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Abdominal epilepsy in patient of schizophrenia - a diagnostic dilemma
PublikacjaAbdominal epilepsy is a rare and uncomman cause of recurrent abdominal pain. It is commonly occuring in children, but rarely in adolescent and elderly. Paroxysmal episodes of abdominal pain with neurological symptoms like dizziness, lethargy, and abnormal electroencephalogram and remarkable response to anticonvulsant confirms the diagnosis. Here we present a case of schizophrenia, who has repoted with recurrent abdominal pain...
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Alzheimers & Dementia
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Cognition and Frailty in Patients With Heart Failure: A Systematic Review of the Association Between Frailty and Cognitive Impairment
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High frequency oscillations are associated with cognitive processing in human recognition memory
PublikacjaHigh frequency oscillations are associated with normal brain function, but also increasingly recognized as potential biomarkers of the epileptogenic brain. Their role in human cognition has been predominantly studied in classical gamma frequencies (30-100 Hz), which reflect neuronal network coordination involved in attention, learning and memory. Invasive brain recordings in animals and humans demonstrate that physiological oscillations...
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Feminismo/s
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Parlement[s]
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The Influence of Selecting Regions from Endoscopic Video Frames on The Efficiency of Large Bowel Disease Recognition Algorithms
PublikacjaThe article presents our research in the field of the automatic diagnosis of large intestine diseases on endoscopic video. It focuses on the methods of selecting regions of interest from endoscopic video frames for further analysis by specialized disease recognition algorithms. Four methods of selecting regions of interest have been discussed: a. trivial, b. with the deletion of characteristic, endoscope specific additions to the...
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Psychogenic Polydipsia leading to Hyponatremia induced Seizure in Schizophrenia.
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COGNITION
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Crossroad between current knowledge and new perspective of diagnostic and therapy of late-onset schizophrenia and very late-onset schizophrenia-like psychosis: An update
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BIOLOGY OF THE NEONATE
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Contextual Knowledge to Enhance Workplace Hazard Recognition and Interpretation in a Cognitive Vision Platform
PublikacjaThe combination of vision and sensor data together with the resulting necessity for formal representations builds a central component of an autonomous Cyber Physical System for detection and tracking of laborers in workplaces environments. This system must be adaptable and perceive the environment as automatically as possible, performing in a variety of plants and scenes without the necessity of recoding the application for each...