Characterization of GM3 Gangliosides in Human Milk throughout Lactation: Insights from the Analysis with the Use of Reversed-Phase Liquid Chromatography Coupled to Quadrupole Time-Of-Flight Mass Spectrometry - Publication - Bridge of Knowledge

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Characterization of GM3 Gangliosides in Human Milk throughout Lactation: Insights from the Analysis with the Use of Reversed-Phase Liquid Chromatography Coupled to Quadrupole Time-Of-Flight Mass Spectrometry

Abstract

Gangliosides are complex lipids found in human milk that play important structural and biological functions. In this study, we utilized reversed-phase liquid chromatography coupled to quadrupole time-of-flight mass spectrometry to evaluate the molecular distribution of GM3 in human milk samples collected at distinct lactation stages, ranging from colostrum to advanced lactation samples. Throughout lactation, GM3 d40:1 emerged as the most abundant GM3 species, except in colostrum, where GM3 d42:2 prevailed. The relative content of GM3 species containing very long N-fatty acyl (N-FA) substituents with >22 carbon atoms decreased, while the content of GM3 species containing 14:0, 18:0, 18:1, and 20:0 N-FA substituents increased in the later months of lactation. These findings highlight the divergence of GM3 profiles across the lactation period. Moreover, considerable interindividual variance was observed among the analyzed samples. The assessment of the GM3 profiles contributes to our understanding of the dynamic composition of human milk.

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DOI:
Digital Object Identifier (open in new tab) 10.1021/acs.jafc.3c04489
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Category:
Articles
Type:
artykuły w czasopismach
Published in:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY no. 71, pages 17899 - 17908,
ISSN: 0021-8561
Language:
English
Publication year:
2023
Bibliographic description:
Hewelt-Belka W., Młynarczyk M., Garwolińska D., Kot-Wasik A.: Characterization of GM3 Gangliosides in Human Milk throughout Lactation: Insights from the Analysis with the Use of Reversed-Phase Liquid Chromatography Coupled to Quadrupole Time-Of-Flight Mass Spectrometry// JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY -Vol. 71,iss. 46 (2023), s.17899-17908
DOI:
Digital Object Identifier (open in new tab) 10.1021/acs.jafc.3c04489
Sources of funding:
  • Free publication
Verified by:
Gdańsk University of Technology

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