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Comparative Lipidomic Study of Human Milk from Different Lactation Stages and Milk Formulas

Abstract

In this report, we present a detailed comparison of the lipid composition of human milk (HM) and formula milk (FM) targeting different lactation stages and infant age range. We studied HM samples collected from 26 Polish mothers from colostrum to 19 months of lactation, along with FM from seven brands available on the Polish market (infant formula, follow-on formula and growing-up formula). Lipid extracts were analysed using liquid chromatography coupled to high-resolution mass spectrometry (LC–Q-TOF–MS). We found that the lipid composition of FM deviates significantly from the HM lipid profile in terms of qualitative and quantitative differences. FM had contrasting lipid profiles mostly across brands and accordingly to the type of fat added but not specific to the target age range. The individual differences were dominant in HM; however, differences according to the lactation stage were also observed, especially between colostrum and HM collected in other lactation stages. Biologically and nutritionally important lipids, such as long-chain polyunsaturated fatty acids (LC-PUFAs) containing lipid species, sphingomyelines or ether analogues of glycerophosphoethanoloamines were detected in HM collected in all studied lactation stages. The observed differences concerned all the major HM lipid classes and highlight the importance of the detailed compositional studies of both HM and FM.

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
Nutrients no. 12,
ISSN: 2072-6643
Language:
English
Publication year:
2020
Bibliographic description:
Hewelt-Belka W., Garwolińska D., Młynarczyk M., Kot-Wasik A.: Comparative Lipidomic Study of Human Milk from Different Lactation Stages and Milk Formulas// Nutrients -Vol. 12,iss. 7 (2020), s.2165-
DOI:
Digital Object Identifier (open in new tab) 10.3390/nu12072165
Verified by:
Gdańsk University of Technology

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