The Production Possibility of the Antimicrobial Filaments by Co-Extrusion of the PLA Pellet with Chitosan Powder for FDM 3D Printing Technology - Publication - Bridge of Knowledge

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The Production Possibility of the Antimicrobial Filaments by Co-Extrusion of the PLA Pellet with Chitosan Powder for FDM 3D Printing Technology

Abstract

The last decades have witnessed a major advancement and development in three-dimensional (3D) printing technology. In the future, the trend’s utilization of 3D printing is expected to play an important role in the biomedical field. This work presents co-extrusion of the polylactic acid (PLA), its derivatives (sPLA), and chitosan with the aim of achieving filaments for printing 3D objects, such as biomedical tools or implants. The physicochemical and antimicrobial properties were evaluated using SEM, FT-IR, DSC, instrumental mechanical test, and based on the ASTM E2149 standard, respectively. The addition of chitosan in the PLA and sPLA filaments increased their porosity and decreased density. The FT-IR analysis showed that PLA and chitosan only formed a physical mixture after extrusion. The addition of chitosan caused deterioration of the mechanical properties of filaments, especially elongation at break and Young’s modulus. The addition of chitosan to the filaments improved their ability to crystallize and provide their antimicrobial properties against Escherichia coli and Staphylococcus aureus.

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
Polymers no. 11, pages 1 - 17,
ISSN: 2073-4360
Language:
English
Publication year:
2019
Bibliographic description:
Mania S., Ryl J., Jinn J., Wang Y., Michałowska A., Tylingo R.: The Production Possibility of the Antimicrobial Filaments by Co-Extrusion of the PLA Pellet with Chitosan Powder for FDM 3D Printing Technology// Polymers -Vol. 11,iss. 11 (2019), s.1-17
DOI:
Digital Object Identifier (open in new tab) 10.3390/polym11111893
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  1. Appuhamillage, G.A. New 3D Printable Polymeric Materials for Fused Filament Fabrication. Ph.D. Thesis, The University of Texas at Dallas, Richardson, TX, USA, 2018.
  2. Ackland, D.C.; Robinson, D.; Redhead, M.; Lee, P.V.S.; Moskaljuk, A.; Dimitroulis, G. A personalized 3D-printed prosthetic joint replacement for the human temporomandibular joint: From implant design to implantation. J. Mech. Behav. Biomed. Mater. 2017, 69, 404-411. [CrossRef] open in new tab
  3. Mils, D.; Weisman, J.; Nicholson, C.; Jammalamadaka, U.; Tappa, K.; Wilson, C. Antibiotic and chemotherapeutic enhanced three-dimensional printer filament and constructs for biomedical applications. Int. J. Nanomed. 2015, 10, 357-370. [CrossRef] open in new tab
  4. Ballard, D.H.; Tappa, K.; Boyer, C.J.; Jammalamadaka, U.; Hemmanur, K.; Weisman, J.A.; Alexander, J.S.; Mills, D.K.; Woodard, P.K. Antiibiotics in 3D-printed implants, instruments and materials: Benefits, challenges and future directions. J. 3D Print. Med. 2019, 3, 83-93. [CrossRef] open in new tab
  5. Lee Ventola, C. Medical Applications for 3D Printing: Current and Projected Uses. Pharmacol. Ther. 2014, 39, 704-711. open in new tab
  6. Tymrak, B.; Kreiger, M.; Pearce, J. Mechanical properties of components fabricated with open-source 3-D printers under realistic environmental conditions. Mater. Des. 2014, 58, 242-246. [CrossRef] open in new tab
  7. Caulfield, B.; McHugh, P.; Lohfeld, S. Dependence of mechanical properties of polyamide components on build parameters in the SLS process. J. Mater. Process. Technol. 2007, 182, 477-488. [CrossRef] open in new tab
  8. Garcia, C.R.; Correa, J.; Espalin, D.; Barton, J.H.; Rumpf, R.C.; Wicker, R.; Gonzalez, V. 3D printing of anisotropic metamaterials. Prog. Electromagn. Res. Lett. 2012, 34, 75-82. [CrossRef] open in new tab
  9. Wang, X.; Jiang, M.; Zhou, Z.; Gou, J.; Hui, D. 3D printing of polymer matrix composites: A review and prospective. Compos. Part B Eng. 2017, 110, 442-458. [CrossRef] open in new tab
  10. Jiang, T.; Munguia-Lopez, J.G.; Flores-Torres, S.; Kort-Mascortm, J.; Kinsella, J.M. Extrusion bioprinting of soft materials: An emerging technique for biological model fabrication. Appl. Phys. 2019, 6, 011310. [CrossRef] open in new tab
  11. Tai, C.; Bouissil, S.; Gantumur, E.; Carranza, M.S.; Yoshii, A.; Sakai, S.; Pierre, G.; Michaud, P.; Delattre, C. Use of natural polysaccharides in the development of 3D bioprinting technology. Appl. Sci. 2019, 9, 2596. [CrossRef] open in new tab
  12. Le Duigou, A.; Castro, M.; Bevan, R.; Martin, N. 3D printing of wood fibre biocomposites: From mechanical to actuation functionality. Mater. Design. 2016, 96, 106-114. [CrossRef] open in new tab
  13. Muzarelli, R.A.A. Chitins and chitosans for the repair of wounded skin. Carbohydr. Polym. 2009, 76, 167-182. [CrossRef] open in new tab
  14. Rinaudo, M. Chitin and chitosan: Properties and applications. Prog. Polym. Sci. 2006, 31, 603-632. [CrossRef] open in new tab
  15. Vunain, E.; Mishra, A.K.; Mamba, B.B. Fundamentals of chitosan for biomedical applications. Chitosan Based Biomater. 2017, 1, 3-30. open in new tab
  16. Kean, T.J.; Thanou, M. Utility of chitosan for 3D Printing and Bioprinting. In Sustainable Agriculture Reviews; open in new tab
  17. Springer: Cham, Switzerland, 2019; Volume 35, pp. 279-284.
  18. Bergonzi, C.; Di Natale, A.; Zimetti, F.; Marchi, C.; Bianchera, A.; Bernini, F.; Silvestri, M.; Bettini, R.; Elviri, L. Study of 3D-printed chitosan scaffold features after different post-printing gelation processes. Sci. Rep. 2019, 9, 362. [CrossRef] [PubMed] open in new tab
  19. Wang, X.; Wei, C.; Cao, W.; Jiang, L.; Hou, Y.; Chang, J. Fabrication of Multiple-layered Hydrogel Sacaffolds with Elaborate Structure and Good Mechanical Properties via 3D-printing and Ionic Reinforcment. ACS Appl. Mater. Interfaces 2018, 10, 18338-18350. [CrossRef] [PubMed] open in new tab
  20. Li, H.; Tan, Y.J.; Liu, S.; Li, L. Three-dimensional bioprinting of oppositely charged hydrogels with super strong interface bonding. ACS Appl. Mater. Interfaces 2018, 10, 11164-11174. [CrossRef] open in new tab
  21. Cai, K.; Yao, K.; Cui, Y.; Lin, S.; Yang, Z.; Li, X.; Xie, H.; Qing, T.; Luo, J. Surface modification of poly (D, L-lactic acid) with chitosan and its effects on the culture of osteoblasts in vitro. J. Biomed. Mater. Res. 2002, 60, 398-404. [CrossRef] open in new tab
  22. Wang, J.; Nor Hidayah, Z.; Razak, S.I.A.; Kadir, M.R.A.; Nayan, N.H.M.; Li, Y.; Amin, K.A.M. Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite. Compos. Interfaces 2019, 26, 465-478. [CrossRef] open in new tab
  23. Sébastien, F.; Stéphane, G.; Copinet, A.; Coma, V. Novel biodegradable films made from chitosan and poly (lactic acid) with antifungal properties against mycotoxinogen strains. Carbohydr. Polym. 2006, 65, 185-193. [CrossRef] open in new tab
  24. Grande, R.; Carvalho, A.J.F. Compatible ternary blends of chitosan/poly (vinyl alcohol)/poly (lactic acid) produced by oil-in-water emulsion processing. Biomacromolecules 2011, 12, 907-914. [CrossRef] [PubMed] open in new tab
  25. Wu, C.S. Modulation, functionality, and cytocompatibility of. three-dimensional printing materials made from chitosan-based polysaccharide composites. Mater. Sci. Eng. C 2016, 69, 27-36. [CrossRef] [PubMed] open in new tab
  26. Mohanty, A.K.; Misra, M.; Drzal, L.T. Natural Fibers, Biopolymers, and Biocomposites, 1st ed.; CRC press: Boca Raton, FL, USA, 2005; pp. 2-31. open in new tab
  27. Ngo, T.D.; Kashani, A.; Imbalzano, G.; Nguyen, K.T.Q.; Hui, D. Additive manufiacturing (3D printing): A review of materials, methods, applications and challenges. Compos. Part B 2018, 143, 172-196. [CrossRef] open in new tab
  28. Cheng, Y.; Deng, S.; Chen, P.; Ruan, R. Polylactic acid (PLA) synthesis and modifications: A review. Front. Chem. China 2009, 4, 259-264. [CrossRef] open in new tab
  29. Auras, R.; Harte, B.; Selke, S. An Overview of Polylactides as Packaging Materials. Macromol. Biosci. 2004, 4, 835-864. [CrossRef] open in new tab
  30. Daver, F.; Marcian Lee, K.P.; Brandt, M.; Shanks, R. Cork-PLA composite filaments for fused deposition modelling. Compos. Sci. Technol. 2018, 168, 230-237. [CrossRef] open in new tab
  31. Chieng, B.W.; Ibrahim, N.A.; Yunus, W.M.Z.W.; Hussein, M.Z. Poly (lactic acid)/Poly (ethylene glycol) Polymer Nanocomposites: Effects of Graphene Nanoplatelets. Polymers 2014, 6, 93-104. [CrossRef] open in new tab
  32. Yang, H.M.; Lee, H.J.; Jang, K.S.; Park, C.W.; Yang, H.W.; Heo, W.D.; Kim, J.D. Poly (amino acid)-coated iron oxide nanoparticles as ultra-small magnetic resonance probes. J. Mater. Chem. 2009, 19, 4566-4574. [CrossRef] open in new tab
  33. Palacio, J.; Orozco, W.H.; López, B.L. Effect of the Molecular weight on the Physicochemical Properties of Poly (lactic acid) Nanoparticles and on the Amount of Ovoalbumin Adsorption. J. Braz. Chem. Soc. 2011, 22, 2304-2311. open in new tab
  34. Popa, E.E.; Rapa, M.; Popa, O.; Mustatea, G.; Popa, V.I.; Mitelut, A.C.; Popa, M.E. Polylactic Acid/Cellulose Fibres Based Composites for Food Packaging Applications. Mater. Plast. 2017, 54, 673-677. open in new tab
  35. Staroszczyk, H.; Sztuka, K.; Wolska, J.; Wojtasz-Pająk, A.; Kołodziejska, I. Interactions of fish gelatin and chitosan in uncrosslinked and crosslinked with EDC films: FT-IR study. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2014, 117, 707-712. [CrossRef] [PubMed] open in new tab
  36. Kasaai, M.R. A review of several reported procedures to determine the degree of N-acetylation for chitin and chitosan using infrared spectroscopy. Carbohydr. Polym. 2008, 71, 497-508. [CrossRef] open in new tab
  37. Číková, E.; Kuliček, J.; Janigová, I.; Omastová, M. Electrospinning of Ethylene Vinyl Acetate/Poly (Lactic Acid) Blends on a Water Surface. Materials 2018, 11, 1737. [CrossRef] [PubMed] open in new tab
  38. Kamthai, S.; Magaraphan, R. Thermal and mechanical properties of polylactic acid (PLA) and bagasse carboxymethyl cellulose (CMCB) composite by adding isosorbide diesters. In AIP Conference Proceedings; open in new tab
  39. Farah, S.; Anderson, D.G.; Manger, R. Physical and mechanical properties of PLA, and their functions in widespread applications-A comprehensive review. Adv. Drug Deliv. Rev. 2016, 107, 367-392. [CrossRef] [PubMed] open in new tab
  40. Mirón, V.; Ferrándiz, S.; Juárez, D.; Mengual, A. Manufacturing and characterization of 3D printer filament using tailoring materials. Procedia Manuf. 2017, 13, 888-894. [CrossRef] open in new tab
  41. Vanleene, M.; Ray, C.; Ho Ba Tho, M.C. Relationships between density and Young's modulus with microporosity and physico-chemical properties of Wistar rat cortical bone from growth to senescence. Med. Eng. Phys. 2008, 30, 1049-1056. [CrossRef] [PubMed] open in new tab
  42. Materials Data Book. Available online: http://www-mdp.eng.cam.ac.uk/web/library/enginfo/cueddatabooks/ materials.pdf (accessed on 3 July 2019).
  43. Carrasco, F.; Pagès, P.; Gámez-Pérez, J.; Santana, O.O.; Maspoch, M.L. Processinfg of poly (lactic acid): Characterization of chemical structure, thermal stability and mechanical properties. Polym. Degrad. Stab. 2010, 95, 116-125. [CrossRef] open in new tab
  44. Noootsuwan, N.; Wattanathana, W.; Jongrungruangchok, S.; Veranitisagul, C.; Koonsaeng, N.; Laobuthee, A. Development of novel hybrid materials from polylactic acid and nano-silver coated carbon black with distinct antimicrobial and electrical properties. J. Polym. Res. 2018, 25, 90. [CrossRef] open in new tab
  45. Mucha, M.; Królikowski, Z. Application of dsc to study crystallization kinetics of polypropylene containing fillers. J. Therm. Anal. Calorim. 2003, 74, 549-557. [CrossRef] open in new tab
  46. Bonilla, J.; Fortunati, E.; Vargas, M.; Chiralt, A.; Kenny, J.M. Effect of chitosan on the phisicochemical and antimicrobial properties of PLA films. J. Food Eng. 2016, 119, 236-243. [CrossRef] open in new tab
  47. Fortunati, E.; Peltzer, M.; Armentano, I.; Torre, L.; Jiménez, A.; Kenny, J.M. Effects of modified cellulose nanocrystals on the barrier and migration properties of PLA nano-biocomposites. Carbohydr. Polym. 2012, 90, 948-956. [CrossRef] open in new tab
  48. Goy, R.C.; de Britto, D.; Assis, O.B.G. A Review of the Antimicrobial Activity of Chitosan. Polímeros 2009, 19, 241-247. [CrossRef] open in new tab
  49. Kong, M.; Chen, X.G.; Xing, K.; Park, H.J. Antimicrobial properties of chitosan and mode of action: A state of the art review. Int. J. Food Microbiol. 2010, 144, 51-63. [CrossRef] open in new tab
  50. Xie, W.; Xu, P.; Wang, W.; Liu, Q. Preparation and antibacterial activity of a water-soluble chitosan derivative. Carbohydr. Polym. 2002, 1, 35-40. [CrossRef] open in new tab
  51. Mania, S.; Tylingo, R.; Augustin, E.; Gucwa, K.; Szwacki, J.; Staroszczyk, H. Investigation of an elutable N-propylphosphonic acid chitosan derivative composition with a chitosan matrix prepared from carbonic acid solution. Cabohydr. Polym. 2018, 179, 196-206. [CrossRef] [PubMed] open in new tab
  52. Damian, L.; Paţchia, S. Method for Testing the Antimicrobial Character of the Materials and Their Fitting to the Scope. Bull. Transilv. Univ. Bras , . 2014, 7, 37-44.
  53. Kaźmierczak, D.; Guzińska, K.; Dymel, M. Antibacterial Activity of PLA Fibers Estimated by Quantitative Methods. Fibres Text. East. Eur. 2016, 2, 126-130. [CrossRef] open in new tab
  54. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). open in new tab
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