displaying 1000 best results Help
Search results for: anti-cancer agents
-
Can popular films instil carcinophobia? Images of cancer in popular Polish cinema
Publication -
Designing a high-sensitivity dual-band nano-biosensor based on petahertz MTMs to provide a perfect absorber for early-stage non-melanoma skin cancer diagnostic
PublicationThe purpose of this study is development of a novel high-performance low-Petahertz (PHz) biosensor for non-melanoma skin cancer (NMSC) diagnosis. The presented device is designed to work within a microwave imaging regime, which is a promising alternative to conventional diagnostic methods such as visual examination, dermoscopy, and biopsy. The suggested biosensor incorporates a dual-band perfect absorber (operating bands at 0.909...
-
Cell Density-Dependent Cytological Stage Profile and Its Application for a Screen of Cytostatic Agents Active Toward Leukemic Stem Cells
PublicationProliferation and expansion of leukemia is driven by leukemic stem cells (LSCs). Multidrug resistance (MDR) of LSCs is one of the main reasons of failure and relapses in acute myeloid leukemia (AML) treatment. In this study, we show that maintaining HL-60 at low cell culture density or applying a 240-day treatment with anthrapyridazone (BS-121) increased the percentage of primitive cells, which include LSCs determining the overall...
-
The role of intestine and liver in glucuronidation of the imidazo- and triazoloacridinone antitumor agents, C-1311 and C-1305: High affinity substrates for UGT1A10
PublicationCelem przeprowadzonych badań było określenie roli poszczególnych izoform UDP-glukuronylotransferazy (UGT)oraz mikrosomów jelita(HIM)i wątroby (HLM) wyizolowanych od różnych pacjentów w metabolizmie pochodnych akrydonu, związków C-1311 i C-1305. Wykazano, że rodziną UGT katalizującą przemiany C-1305 i C-1311 jest UGT1A, z najwyższą aktywnością wykazywaną przez pozawątrobowy izoenzym UGT1A10. Rozkład aktywności frakcji mikrosomalnych...
-
Amphotericin B derivatives: novel strategy for the development of non-toxic, broad spectrum, fungicidal and overcoming multidrug resistance antifungal agents.
PublicationZaprezentowano porównawczą charakterystykę działania amfoterycyny B (AmB) oraz jej pochodnych o różnym stopniu selektywnej toksyczności na szczepy grzybów reperezentujących różne mechanizmy oporności. Były to mutanty C. albicans posiadające defekt w szlaku biosyntezy ergosterolu oraz wielolekooporne szczepy S. cerevisiae wyposażone w pompy eksportujące typu ABC i MFS. Badania obejmowały: 1)porównanie aktywności przeciwgrzybowej...
-
NADPH-Cytochrome P-450 reductase in strongly involved in activating metabolic transformatios of 9-amino-1-nitroacridine antitumor agents
PublicationCelem pracy było wyjaśnienie roli reduktazy cytochromu P-450 jaką odgrywa ten enzym w przemianach metabolicznych dwóch związków przeciwnowotworowych z grupy pochodnych 1-nitroakrydyny. Zastosowano metodę HPLC do rozdziału metabolitów, a badania struktur przeprowadzono stosując metodę ESI-MS. Wykazano, że badana reduktaza jest zaangażowana bardziej w metabolizm aktywacyjny 1-nitroakrydyn niż metabolizm detoksykacyjny.
-
Radiation Therapy–Related Changes in Serum Proteome and Lipidome Are Primarily Associated With a Type of Acute Toxicity: Comparison of Radiation-Induced Effects in Patients Treated Because of Head and Neck Cancer or Prostate Cancer
Publication -
Andrzej Składanowski prof. dr hab. inż.
People -
Cytotoxicity of QDgreen-holo-Tf-C-2028 and QDred-holo-Tf-C-2028 aginst H460 cancer cells_method of synthesis 2
Open Research DataThis study presents absorbance of formazan product (converted from MTT) which corresponds the cytotoxicity of QDgreen-holo-Tf-C-2028 and QDred-holo-Tf-C-2028 aginst H460 cancer cells (method of synthesis 2). Holo-Tf (transferrin) was used as a linker between quantum dots (QDs) and compound (C-2028).
-
Cytotoxicity of QDgreen-holo-Tf-C-2028 and QDred-holo-Tf-C-2028 aginst H460 cancer cells_method of synthesis 3
Open Research DataThis study presents absorbance of formazan product (converted from MTT) which corresponds the cytotoxicity of QDgreen-holo-Tf-C-2028 and QDred-holo-Tf-C-2028 aginst H460 cancer cells (method of synthesis 3). Holo-Tf (transferrin) was used as a linker between quantum dots (QDs) and compound (C-2028).
-
The absorption and fluorescence spectra of novel bisacridines (IKE15-19, IKE21) and IE10, potential antifungal agents
Open Research DataOptical measurements of novel bisacridines (IKE15-19, IKE21) and IE10 were conducted. The absorption spectra were recorded from 300 to 800 nm. The fluorescence emission spectra were determined with excitation and emission wavelengths described in the file. All measurements were recorded using a multiplate reader, Tecan Spark 10M.
-
Agnieszka Pastula Dr
PeopleAgnieszka received her masters degree in biology at Jagiellonian University (Poland). Besides standard university classes, she did multiple extracurricular research internships in both basic science and medical life sciences e.g. at Warsaw University, Jagiellonian University College of Medicine, University of Medical Sciences in Poznań and University Medical Center Utrecht, that provided her with excellent interdisciplinary training...
-
Is sequential batch reactor an efficient technology to protect recipient against non-steroidal anti-inflammatory drugs and paracetamol in treated wastewater?
PublicationThe tested facility was a wastewater treatment plant (WWTP) in Swarzewo, where the wastewater treatment takes place in aeration chambers with activated sludge using sequential batch reactors (SBRs). The concentration of the following pharmaceuticals: ibuprofen, paracetamol, flurbiprofen, naproxen, diclofenac, and its metabolites 5OH-diclofenac and 4OH-diclofenac was tested in influents and effluents. Simultaneously, the conventional...
-
Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity
Publication -
Pharmacokinetics and Pharmacodynamics of a Chimeric/Humanized Anti-CD3 Monoclonal Antibody, Otelixizumab (TRX4), in Subjects With Psoriasis and With Type 1 Diabetes Mellitus
Publication -
Comparison of stress perceptions and coping strategies among students exposed to COVID-19 in countries with different approaches to anti-pandemic activities
Publication -
The Potential Use of Citrus aurantifolia L. Essential Oils for Decay Control, Quality Preservation of Agricultural Products, and Anti-Insect Activity
Publication -
Deformation of thin metal and composite sheets by using anti-buckling fixture for large deformation under tension–compression cyclic loading
Publication -
Effects of extreme pressure and anti-wear additives on surface topography and tool wear during MQCL turning of AISI 1045 steel
Publication -
The chaperone-usher pathway of bacterial adhesin biogenesis - from molecular mechanism to strategies of anti-bacterial prevention and modern vaccine design
PublicationSystem chaperone-usher (białko opiekuńcze-białko kanałotwórcze) warunkuje biogenezę powierzchniowych struktur adhezyjnych, odpowiedzialnych za wirulencję wielu bakterii gram-ujemnych. Powyższy mechanizm został zbadany na poziomie strukturalnym w przypadku różnych gatunków bakterii patogennych. Celem powyższej pracy było przedstawienie molekularnego mechanizmu biogenezy struktur adhezyjnych na bazie systemu chaperone-usher. Otrzymane...
-
Prognostic Value of TOP2A Gene Amplification and Chromosome 17 Polysomy in Early Breast Cancer
Publication -
Aggressive Phenotype of Cells Disseminated via Hematogenous and Lymphatic Route in Breast Cancer Patients
Publication -
Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells
Publication -
Sulforaphene, an isothiocyanate present in radish plants, inhibits proliferation of human breast cancer cells
Publication -
Identification of serum proteome signatures of locally advanced and metastatic gastric cancer: a pilot study
Publication -
The modulatory effect of green tea catechin on drug resistance in human ovarian cancer cells
Publication -
Structure–bioavailability relationship study of genistein derivatives with antiproliferative activity on human cancer cell
Publication -
Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells
Publication -
Aberrant repair of etheno–DNA adducts in leukocytes and colon tissue of colon cancer patients
Publication -
A potency of plasminogen activation system in long-term prognosis of endometrial cancer: a pilot study
Publication -
Drug transporter expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line
Publication -
Microneedle‐Based Generation of Microbubbles in Cancer Tumors to Improve Ultrasound‐Assisted Drug Delivery
Publication -
Carbon nanotube based dielectric spectroscopy of tumor secretion; electrochemical lipidomics for cancer diagnosis
Publication -
Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics
Publication -
Patient with metastatic breast cancer presenting as acute cholecystitis with one-year survival on hormonotherapy
Publication -
An unusual case of CTEPH treated by BPA in a patient with a single lung after cancer surgery
Publication -
Retrospective assessment of Lung-RADS® performance in the Silesian Lung Cancer Screening Pilot Study
Publication -
Physical activity, life satisfaction and adjustment to illness in women after treatment of breast cancer
Publication -
Effective kernel‐principal component analysis based approach for wisconsin breast cancer diagnosis
Publication -
Altered levels of nucleoside metabolite profiles in urogenital tract cancer measured by capillary electrophoresis
Publication -
Liquid chromatography tandem mass spectrometry study of urinary nucleosides as potential cancer markers
Publication -
Analysis of urinary nucleosides as potential cancer markers determined using LC–MS technique
Publication -
Statistical-based approach in potential diagnostic application of urinary nucleosides in urogenital tract cancer
Publication -
New approach in determination of urinary diagnostic markers for prostate cancer by MALDI-TOF/MS
Publication -
DNA variants in Helicobacter pylori infected patients with chronic gastritis, dysplasia and gastric cancer
Publication -
DNA Variants in Helicobacter Pylori Infected Patients with Chronic Gastritis, Dysplasia and Gastric Cancer
Publication -
Physical and psychological impairments of women with upper limb lymphedema following breast cancer treatment
Publication -
Non-vitamin K antagonist oral anticoagulants (NOACs) in cancer patients with atrial fibrillation
Publication -
Nanosized zinc, epigenetic changes and its relationship with DMBA induced breast cancer in rats
Publication -
Autofagia: mechanizm molekularny, apoptoza i nowotwory = Autophagy: molecular mechanism, apoptosis and cancer
PublicationW pracy omówiono molekularny mechanizm autofagii oraz najważniejsze szlaki sygnałowe uczestniczące w regulacji przebiegu tego procesu w komórkach nowotworowych. Omówiona została również dwojaka rola autofagii w procesie nowotworzenia oraz skutki zarówno indukcji, jak i inhibicji autofagii w terapii przeciwnowotworowej