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Search results for: CANCER
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Influence of interfraction motion on margins for radiotherapy of gastric cancer
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miRNAs in Signal Transduction of SMAD Proteins in Breast Cancer
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The Effects of Single Nucleotide Polymorphisms in Cancer RNAi Therapies
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Coping strategies and sexual satisfaction in bladder cancer males
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Novel Inhibitor-Based Therapies for Thyroid Cancer—An Update
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Inhibitors of angiogenesis in cancer therapy – synthesis and biological activity
PublicationAngiogenesis is the process of formation of new capillaries from preexisting blood vessels. Angiogenesis is involved in normal physiological processes, and plays an important role in tumor invasion and development of metastases. Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis. VEGF is a mitogen for vascular endothelial cells and stimulates their proliferation. By inhibiting the biological activity of...
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Neural network breast cancer relapse time prognosis
PublicationPrzedstawiono architekturę i wyniki testowania sztucznej sieci neuronowej w prognozowaniu czasu nawrotu choroby u kobiet chorych na raka piersi. Sieć neuronowa uczona była na danych zgromadzonych przez 20 lat. Dane opisują grupę 439 pacjentów za pomocą 40 parametrów. Spośród tych parametrów wybrano 6 najistotniejszych: liczbę przerzutowych węzłów chłonnych, wielkość guza, wiek, skalę według Blooma oraz stan receptorów estrogenowych...
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The Four-Feature Prognostic Models for Cancer-Specific and Overall Survival after Surgery for Localized Clear Cell Renal Cancer: Is There a Place for Inflammatory Markers?
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Cancer stem cells in drug resistance and drug screening: can we exploit the cancer stem cell paradigm in search for new antitumor agents?
PublicationPraca przedstawia przegląd literatury dotyczącej hipotezy komórek pierwotnych nowotworu, w szczególności w ich oporności na istniejące terapie. Dyskutowane jest także zagadnienie możliwości wykorzystania wiedzy o tych komórkach do konstrukcji nowych testów do badań przesiewowych in vitro w celu poszukiwania nowych leków przeciwnowotworowych.
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TRF1 and TRF2: pioneering targets in telomere-based cancer therapy
PublicationThis article presents an in-depth exploration of the roles of Telomere Repeat-binding Factors 1 and 2 (TRF1 and TRF2), and the shelterin complex, in the context of cancer biology. It emphasizes their emerging significance as potential biomarkers and targets for therapeutic intervention. Central to the shelterin complex, TRF1 and TRF2 are crucial in maintaining telomere integrity and genomic stability, their dysregulation often...
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Can We Go beyond Pathology? The Prognostic Role of Risk Scoring Tools for Cancer-Specific Survival of Patients with Bladder Cancer Undergoing Radical Cystectomy
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Terahertz Dual-Band Metamaterial Biosensor for Cervical-Cancer Diagnostics
PublicationThis study highlights the potential of employing terahertz metamaterial structures as dual-band biosensors for the early detection of cancerous biological tissue. The fundamental principle leveraged here is the alteration of the effective dielectric constant of biological tissue by cancerous cells. The change in the dielectric constant, in turn, induces a shift in the resonance frequency of the metamaterial sensor. One notable...
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Survival time prognosis under a Markov model of cancer development
PublicationIn this study we look at a breast cancer data set of women from Pomerania region collected in year 1987-1992 in the Medical University of Gdańsk. We analyze the clinical risk factors in conjunction with Markov model of cancer development. We evaluate Artificial Neural Network (ANN) survival time prediction via a simulation study.
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Diamond Nanofilm Normalizes Proliferation and Metabolism in Liver Cancer Cells
PublicationPurpose: Surgical resection of hepatocellular carcinoma can be associated with recurrence resulting from the degeneration of residual volume of the liver. The objective was to assess the possibility of using a biocompatible nanofilm, made of a colloid of diamond nanoparticles (nfND), to fill the side after tumour resection and optimize its contact with proliferating liver cells, minimizing their cancerous transformation. Methods:...
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Folate/homocysteine metabolism and lung cancer risk among smokers
PublicationBackground: Folate and homocysteine are involved in DNA synthesis and methylation processes, which are deregulated during carcinogenesis. Objectives: The aim of this study was to assess the relationship between folate/homocysteine concentrations, the functional polymorphisms of folate/homocysteine genes and lung cancer risk among cigarette smokers. Study design: The study included 132 lung cancer patients and 396 controls from...
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Serum mass profile signature as a biomarker of early lung cancer
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An inherited NBN mutation is associated with poor prognosis prostate cancer
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The presence of prostate cancer at biopsy is predicted by a number of genetic variants
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(CA)n Microsatellite polymorphism of ERBB-1 in breast cancer
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A deletion in CHEK2 of 5,395 bp predisposes to breast cancer in Poland
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XPD Common Variants and their Association with Melanoma and Breast Cancer Risk
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Cancer Familial Aggregation (CFA) and G446A polymorphism in ARLTS1 gene
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Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways
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Microbiota-derived metabolites in colorectal cancer patients in preoperative period
PublicationShort-chain fat-ty acids (SCFAs) are microbial derived metabo-lites, which have multiple beneficial properties. The amount of SCFAs depends on several fac-tors, such as age, diet (mainly intake of dietary fiber), and overall health condition. The normal proportion between SCFAs is 3:1:1 for acetate, proprionate and butyrate, respectively. In col-orectal cancer (CRC) patients, microbiota alter-ations have been shown. Consequently,...
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Common variants of xeroderma pigmentosum genes and prostate cancer risk
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The ICTBioMed NCIP Hub: Cancer research in a science gateway consortium
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Nuclear quantum effects in a HIV/cancer inhibitor: The case of ellipticine
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Pemphigus foliaceus in a patient with skin cancer with metastases to lymph nodes
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VEGF – targeted therapy for the treatment of cervical cancer – literature review
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Analysis of 5-Methylcytosine in DNA of Breast and Colon Cancer Tissues
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Sulforaphane inhibits growth of phenotypically different breast cancer cells
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Biological Effects of Cold Atmospheric Pressure Plasma on Skin Cancer
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The p53-mediated cytotoxicity of photodynamic therapy of cancer: Recent advances
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Clinical Relevance of Circulating Tumor Cells in Prostate Cancer Management
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The analysis of absorbed dose by pancreas during gastric cancer radiotherapy
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C-reactive Protein as a Diagnostic and Prognostic Factor of Endometrial Cancer
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The effects of RNA editing in cancer tissue at different stages in carcinogenesis
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Bladder cancer detection using a peptide substrate of the 20S proteasome
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Extracellular miRNAs as Biomarkers of Head and Neck Cancer Progression and Metastasis
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C-reactive protein as a diagnostic and prognostic factor of endometrial cancer
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Metabolic profiling of pteridines for determination of potential biomarkers in cancer diseases
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Comparison of Pteridine Normalization Methods in Urine for Detection of Bladder Cancer
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Notch signalling pathway as an oncogenic factor involved in cancer development
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The role of Snail1 transcription factor in colorectal cancer progression and metastasis
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The Role of miRNA-7 in the Biology of Cancer and Modulation of Drug Resistance
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New Unsymmetrical Bisacridine Derivatives Noncovalently Attached to Quaternary Quantum Dots Improve Cancer Therapy by Enhancing Cytotoxicity toward Cancer Cells and Protecting Normal Cells
PublicationThe use of nanoparticles for the controlled drug delivery to cells has emerged as a good alternative to traditional systemic delivery. Quantum dots (QDs) offer potentially invaluable societal benefits such as drug targeting and in vivo biomedical imaging. In contrast, QDs may also pose risks to human health and the environment under certain conditions. Here, we demonstrated that unique combination of nanocrystals core components...
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Stage I non-small-cell lung cancer: long-term results of lobectomy versus sublobar resection from the Polish National Lung Cancer Registry†
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Comparison of peptide cancer signatures identified by mass spectrometry in serum of patients with head and neck, lung and colorectal cancers: Association with tumor progression
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CANCER BIOLOGY & THERAPY
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Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract
PublicationThe present article includes data on the possible selective cytotoxic effect of extract of Ribes nigrum L. growing at high Armenian landscape. For this purpose, different non-cancer (microglial BV-2 wild type (Wt), acyl-CoA oxidase 1 (ACOX1) deficient (Acox1-/-) and cancer (human colon adenocarcinoma HT29 and human breast cancer MCF7) cell lines were applied. R. nigrum leaf ethanol extract showed a growth inhibition effect towards...