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Search results for: prostate cancer
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The Influence of The Light-Activated Titania P25 on Human Breast Cancer Cells
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Expression of Selected Epithelial-Mesenchymal Transition Transcription Factors in Endometrial Cancer
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25(OH)D3 in patients with ovarian cancer and its correlation with survival
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Serum Inhibin A and Inhibin B Levels in Epithelial Ovarian Cancer Patients
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Serum Anti-Müllerian Hormone Levels in Patients with Epithelial Ovarian Cancer
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Inhibitory mikrotubul w terapii przeciwnowotworowej = Inhibitors of microtubule in cancer therapy
PublicationW artykule opisano inhibitory mikrotubul, różnorodne związki chemiczne, znajdujące się w zaawansowanych przedklinicznych i wstępnych badaniach klinicznych. Pośród nich na uwagę zasługują półsyntetyczne analogi taksolu, substancje pochodzenia naturalnego, takie jak: epotilony, kombretastatyny, kolchinoidy, dolastatyny oraz syntetyczne związki o niskim ciężarze czasteczkowym: heterokombretastatyny, sulfonamidy, fenostatyny, pochodne...
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H2AX phosphorylation, its role in DNA damage response and cancer therapy
PublicationDouble-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect...
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Predictions of cervical cancer identification by photonic method combined with machine learning
PublicationCervical cancer is one of the most commonly appearing cancers, which early diagnosis is of greatest importance. Unfortunately, many diagnoses are based on subjective opinions of doctors—to date, there is no general measurement method with a calibrated standard. The problem can be solved with the measurement system being a fusion of an optoelectronic sensor and machine learning algorithm to provide reliable assistance for doctors...
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The Influence of Antitumor Unsymmetrical Bisacridines on 3D Cancer Spheroids Growth and Viability
PublicationThe culture of 3D spheroids is a promising tool in drug development and testing. Recently, we synthesized a new group of compounds, unsymmetrical bisacridines (UAs), which exhibit high cytotoxicity against various human cell lines and antitumor potency against several xenografts. Here, we describe the ability of four UAs—C-2028, C-2041, C-2045, and C-2053—to influence the growth of HCT116 and H460 spheres and the viability of HCT116...
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Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract
PublicationThe present article includes data on the possible selective cytotoxic effect of extract of Ribes nigrum L. growing at high Armenian landscape. For this purpose, different non-cancer (microglial BV-2 wild type (Wt), acyl-CoA oxidase 1 (ACOX1) deficient (Acox1-/-) and cancer (human colon adenocarcinoma HT29 and human breast cancer MCF7) cell lines were applied. R. nigrum leaf ethanol extract showed a growth inhibition effect towards...
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A simple access to o-acyl bicyne
PublicationW publikacji przedstawiono prostą metodę otrzymywania o-acylowych pochodnych bicyny. Substratem do syntezy była n,n-bis(2-hydroksyetylo)glicyna - bicyna. Bicynę najpierw przeprowadzano w ester benzylowy w reakcji z alkoholem benzylowym i kwasem p-toluenosulfonowym w temp. 75 st. C. Tak otrzymany związek, acylowano kwasami organicznymi w obecności DCC ( dicyklokeksylokarbodiimid)i DMAP (dimetyloaminopirydyna), otrzymując o-acylowe...
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Differential Response of MDA-MB-231 and MCF-7 Breast Cancer Cells to In Vitro Inhibition with CTLA-4 and PD-1 through Cancer-Immune Cells Modified Interactions
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Resistance of human prostate carcinoma cells to a new antitumor compound capridine beta is associated with changed drug metabolism combined with both inherent and drug-induced overexpression of ABC transporters
PublicationW pracy charakteryzujemy mechanizm oporności na nową pochodną 1-nitroakrydyny, związku capridine beta (C-1748) o wysokiej aktywności przeciwnowotworowej, znajdującego się w badaniach klinicznych. Nasze dane wskazują, że oporność na ten związek jest wynikiem zmienionego metabolizmu inaktywującego C-1748 oraz wzrostem ekspresji pompy błonowej ABCG2 a także innych białek transportowych typu ABC.
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Altered circadian genes expression in breast cancer tissue according to the clinical characteristics
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The impact of the Polish mass breast cancer screening program on prognosis in the Pomeranian Province
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Prognostic Significance of TOP2A Gene Dosage in HER-2-Negative Breast Cancer
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Serum MicroRNAs as Xerostomia Biomarkers in Patients With Oropharyngeal Cancer Undergoing Radiation Therapy
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Bayesian multilevel model of micro RNA levels in ovarian-cancer and healthy subjects
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Myeloid-derived suppressor cells (MDSCs) in brain cancer: challenges and therapeutic strategies
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The Occurrence of Cancer and of Adenomae in the Large Bowel and the Concentration of N -Nitrosamines in the Gastric Juice
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Advanced Assessment of the Endogenous Hormone Level as a Potential Biomarker of the Urogenital Tract Cancer
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The Relationship of Purpose in Life and Hope in Shaping Happiness Among Patients with Cancer in Poland
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Risk factors assessment and risk prediction models in lung cancer screening candidates
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Vimentin immunoexpression and its prognostic activity in colon cancer among Caucasian patients
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Near-Infrared Fluorescence Image-Guided Surgery in Esophageal and Gastric Cancer Operations
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From chemoresistance to cancer stem cells: the case of BRCP/ABCG2 half transporter
PublicationLudzkie białko ABCG2 jest pompą typu ABC tworzącą homodimery i aktywnie transportującą leki i inne substraty naturalne i syntetyczne. Nadekspresja tego białko prowadzi do oporności na leki przeciwnowotworowe. Białko ABCG2 występuje w wielu formach zmutowanych, różniących się własnościami substratowymi, stąd istotne dla oporności na leki jest jaka forma genu i białka ABCG2 ulega nadekspresji w komórce. Ostatnie badania wskazują,...
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Can popular films instil carcinophobia? Images of cancer in popular Polish cinema
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CDKN2A common variant and multi-organ cancer risk—a population-based study
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Therapy with CD4+CD25+ T regulatory cells – should we be afraid of cancer?
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Germline mutations in theCHEK2 kinase gene are associated with an increased risk of bladder cancer
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Polymorphisms in nucleotide excision repair genes and susceptibility to colorectal cancer in the Polish population
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Radiation Therapy-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients
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314 Osteopontin as a Potential Serum Marker in Early Breast Cancer-Preliminary Results
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The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family
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Altered levels of circulating nuclear and mitochondrial DNA in patients with Papillary Thyroid Cancer
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Prognostic value of 5-microRNA based signature in T2-T3N0 colon cancer
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Synthesis of Usnic Acid Derivatives and Evaluation of Their Antiproliferative Activity against Cancer Cells
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Role of Curcumin and (−)-Epigallocatechin-3-O-Gallate in Bladder Cancer Treatment: A Review
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Delving into the Nutraceutical Benefits of Purple Carrot against Metabolic Syndrome and Cancer: A Review
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Can popular films instil carcinophobia? Images of cancer in popular Polish cinema
PublicationIntroduction: Although cancer is currently considered a serious socio-medical challenge and health education in Poland has been positioned as a public health priority, the impact of popular culture on people’s ideas about cancer has been neglected. This study therefore aims to analyse the way popular Polish films portray cancer and the experience of cancer.Material and Methods: Seven popular Polish films featuring cancer...
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FGF7 / FGFR2 – JunB signalling counteracts the effect of progesterone in luminal breast cancer
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Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
PublicationHeterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based...
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Environmental exposure to cadmium in breast cancer – association with the Warburg effect and sensitivity to tamoxifen
PublicationThe association between cadmium and breast cancer remains unexplained due to inconsistent epidemiological data and unknown underlying mechanisms. This study aimed to assess the relationship between environmental exposure to cadmium and the Warburg effect in breast cancer and, thus, its possible interference with breast cancer treatment. The observational study in two groups of breast cancer patients indicated a positive correlation between...
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Saliva as a first-line diagnostic tool: A spectral challenge for identification of cancer biomarkers
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Application of a three‑dimensional (3D) breast cancer model to study macrophage polarization
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Tissue Rheology as a Possible Complementary Procedure to Advance Histological Diagnosis of Colon Cancer
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Melanoma skin cancer detection using mask-RCNN with modified GRU model
PublicationIntroduction: Melanoma Skin Cancer (MSC) is a type of cancer in the human body; therefore, early disease diagnosis is essential for reducing the mortality rate. However, dermoscopic image analysis poses challenges due to factors such as color illumination, light reflections, and the varying sizes and shapes of lesions. To overcome these challenges, an automated framework is proposed in this manuscript. Methods: Initially, dermoscopic...
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Deep Learning-Based, Multiclass Approach to Cancer Classification on Liquid Biopsy Data
PublicationThe field of cancer diagnostics has been revolutionized by liquid biopsies, which offer a bridge between laboratory research and clinical settings. These tests are less invasive than traditional biopsies and more convenient than routine imaging methods. Liquid biopsies allow studying of tumor-derived markers in bodily fluids, enabling the development of more precise cancer diagnostic tests for screening, disease monitoring, and...
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Deep Learning-Based, Multiclass Approach to Cancer Classification on Liquid Biopsy Data
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Potential plasma biomarkers of bladder cancer identified by proteomic analysis: A pilot study
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