Search results for: metabolizm lekow

• DRUG METABOLISM AND DISPOSITION

  Journals

  ISSN: 0090-9556 , eISSN: 1521-009X

• DRUG METABOLISM REVIEWS

  Journals

  ISSN: 0360-2532 , eISSN: 1097-9883

• Electrochemical simulation of enzymatic transformations studied for the selected antitumor acridine derivatives

  Publication

  • A. Potęga
  • W. Hewelt-Belka
  • O. Siewruk
  • K. Zapała
  • Z. Mazerska

  - Year 2014

  The elucidation of the metabolic pathways and the biotransformation mechanisms of potential drugs is a crucial point in drug development. It allows to know the activation routes of the new biologically active compounds, especially in respect to their possible toxicity. Generally, in vivo or in vitro experiments with liver microsomes or hepatocytes are performed. However, these testing schemes are tedious, time consuming and of...

• Bisphenol A analogues and metabolic syndrome in women with polycystic ovary syndrome

  Publication

  • J. Majewska
  • A. Berg
  • J. Jurewicz
  • K. Owczarek
  • R. Zajdel
  • A. Kilanowicz
  • A. Wasik
  • D. Rachoń

  - REPRODUCTIVE TOXICOLOGY - Year 2024

  Bisphenols (BPs) have become a chemical group of special interest due to their ability to interfere with the endocrine system and their ubiquitous presence in the environment. As some of them possess mild estrogenic and anti-androgenic effects, they might be associated with the diagnosis of polycystic ovary syndrome (PCOS). Acting on multiple tissues, BPs exposure may lead to metabolic derangements characteristic for metabolic...

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• IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection

  Publication

  • G. Griffante
  • W. Hewelt-Belka
  • C. Albano
  • F. Gugliesi
  • S. Pasquero
  • S. F. Castillo Pacheco
  • G. Bajetto
  • P. E. Porporato
  • E. Mina
  • M. Vallino... and 7 others

  - mBio - Year 2022

  Cellular lipid metabolism plays a pivotal role in human cytomegalovirus (HCMV) infection, as increased lipogenesis in HCMV-infected cells favors the envelopment of newly synthesized viral particles. As all cells are equipped with restriction factors (RFs) able to exert a protective effect against invading pathogens, we asked whether a similar defense mechanism would also be in place to preserve the metabolic compartment from HCMV...

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• Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering

  Publication

  • D. Šamec
  • M. Tomczyk
  • L. Milella
  • D. Russo
  • S. Habtemariam
  • I. Suntar
  • L. Rastrelli
  • M. Daglia
  • J. Xiao
  • F. Giampieri... and 7 others

  - Biotechnology Advances - Year 2020

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• Carbon assimilation profiles of mucoralean fungi show their metabolic versatility

  Publication

  • J. Pawłowska
  • A. Okrasińska
  • K. Kisło
  • T. Aleksandrzak-Piekarczyk
  • K. Szatraj
  • S. Dolatabadi
  • A. Muszewska

  - Scientific Reports - Year 2019

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• The metabolic syndrome in hypertension: European society of hypertension position statement

  Publication

  • J. Redon
  • R. Cifkova
  • S. Laurent
  • P. Nilsson
  • K. Narkiewicz
  • S. Erdine
  • G. Mancia

  - JOURNAL OF HYPERTENSION - Year 2008

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• Electronic Cigarette Use and Metabolic Syndrome Development: A Critical Review

  Publication

  • I. Górna
  • M. Napierala
  • E. Florek

  - Toxics - Year 2020

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• The usefulness of fluorescence in detecting ischemia during bariatric and metabolic surgery

  Publication

  • M. Wityk
  • N. Dowgiałło-Gornowicz
  • M. Bobowicz

  - Year 2024

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• A numerical scale to assess the outcomes of metabolic/bariatric surgery (NOMS)

  Publication

  • M. Michalik
  • M. Bobowicz
  • H. Buchwald

  - Wideochirurgia i Inne Techniki Maloinwazyjne - Year 2015

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• Metabolic profiling of pteridines for determination of potential biomarkers in cancer diseases

  Publication

  • P. Kośliński
  • R. Bujak
  • E. Daghir
  • M. Markuszewski

  - ELECTROPHORESIS - Year 2011

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• Significance of selected inflammatory factors in metabolic disorders in association with psoriasis

  Publication

  • P. Kiluk
  • A. Baran
  • I. Flisiak

  - Przegląd Dermatologiczny - Year 2017

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• Synteza i badania biologiczne nowych analogów kwasu mykofenolowego z pochodnymi adenozyny jako potencjalnych leków immunosupresyjnych

  Publication

  • M. Prejs

  - Year 2017

  Przedstawiona praca doktorska pt. „Synteza i badania biologiczne nowych analogów kwasu mykofenolowego z pochodnymi adenozyny jako potencjalnych leków immunosupresyjnych” poświęcona jest związkom immunosupresyjnym opartym o cząsteczkę kwasu mykofenolowego oraz pochodnych adenozyny. Z medycznego punktu widzenia, gdy długotrwała choroba lub nagły przypadek powoduje nieodwracalny uraz tkanek, komórek lub niewydolność organu i żadna...

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• „Odwrócony łańcuch dystrybucji leków” – o przyczynach, skutkach oraz sposobach zwalczania tego zjawiska i zapobiegania mu

  Publication

  • P. Bróżek

  - Młoda Palestra – Czasopismo Aplikantów Adwokackich - Year 2022

• DIABETES-METABOLISM RESEARCH AND REVIEWS

  Journals

  ISSN: 1520-7552 , eISSN: 1520-7560

• International Journal of Endocrinology and Metabolism

  Journals

  ISSN: 1726-913X , eISSN: 1726-9148

• Journal of Drug Metabolism & Toxicology

  Journals

  ISSN: 2157-7609

• Expert Review of Endocrinology & Metabolism

  Journals

  ISSN: 1744-6651 , eISSN: 1744-8417

• Mediterranean Journal of Nutrition and Metabolism

  Journals

  ISSN: 1973-798X , eISSN: 1973-7998

• Indian Journal of Endocrinology and Metabolism

  Journals

  ISSN: 2230-8210

• Therapeutic Advances in Endocrinology and Metabolism

  Journals

  ISSN: 2042-0188 , eISSN: 2042-0196

• Iranian Journal of Endocrinology and Metabolism

  Journals

  ISSN: 1683-4844

• Annals of Pediatric Endocrinology and Metabolism

  Journals

  ISSN: 2287-1012

• Journal of Nutrition and Intermediary Metabolism

  Journals

  eISSN: 2352-3859

• Turkish Journal of Endocrinology and Metabolism

  Journals

  ISSN: 1301-2193

• Drug Metabolism and Personalized Therapy

  Journals

  ISSN: 2363-8907

• JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

  Journals

  ISSN: 0021-972X , eISSN: 1945-7197

• Chinese Journal of Endocrinology and Metabolism

  Journals

  ISSN: 1000-6699

• JOURNAL OF BONE AND MINERAL METABOLISM

  Journals

  ISSN: 0914-8779 , eISSN: 1435-5604

• JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

  Journals

  ISSN: 0334-018X , eISSN: 2191-0251

• International Journal of Diabetes and Metabolism

  Journals

  ISSN: 1606-7754

• Completing Autophagy: Formation and Degradation of the Autophagic Body and Metabolite Salvage in Plants

  Publication

  • S. Stefaniak
  • Ł. Wojtyla
  • M. Pietrowska-Borek
  • S. Borek

  - International Journal of Molecular Sciences - Year 2020

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• Phase I and phase II metabolism simulation of antitumor-active 2-hydroxyacridinone with electrochemistry coupled on-line with mass spectrometry.

  Publication

  • A. Potęga
  • D. Garwolińska
  • A. M. Nowicka
  • M. Fau
  • A. Kot-Wasik
  • Z. Mazerska

  - XENOBIOTICA - Year 2019

  Here, we report the metabolic profile and the results of associated metabolic studies of 2-hydroxyacridinone (2-OH-AC), the reference compound for antitumor-active imidazo- and triazoloacridinones. Electrochemistry coupled with mass spectrometry was applied to simulate the general oxidative metabolism of 2-OH-AC for the first time. The reactivity of 2-OH-AC products to biomolecules was also examined. The usefulness of the electrochemistry...

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• Metabolism of antitumour agent 1-nitroacridine derivative, C-1748 in pancreatic cancer cell lines

  Publication

  • A. Mróz
  • B. Borowa-Mazgaj
  • Z. Mazerska

  - Acta Biochimica Polonica - Year 2015

  Pancreatic cancer has the highest mortality rate of all major cancers because of limited treatment options. Surgical removal of the tumour is possible only in its early stage, nevertheless the asymptomatic development very often makes unable an accurate diagnose. In the case of metastatic pancreatic cancer only chemotherapy, mainly with gemcitabine, can be offered to patients. However, common resistance towards gemcitabine imposes...

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• Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse

  Publication

  • J. Podolak-Popinigis
  • B. Górnikiewicz
  • A. Ronowicz
  • P. Sachadyn

  - BMC GENOMICS - Year 2015

  Background: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...

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• Photosynthesis and sucrose metabolism in leaves of Arabidopsis thaliana aos, ein4 and rcd1 mutants as affected by wounding

  Publication

  • E. Lukaszuk
  • M. Rys
  • K. Możdżeń
  • I. Stawoska
  • A. Skoczowski
  • I. Ciereszko

  - ACTA PHYSIOLOGIAE PLANTARUM - Year 2017

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• Integrating conventional nitrogen removal with anammox in wastewater treatment systems: Microbial metabolism, sustainability and challenges

  Publication

  • H. Al-Hazmi
  • G. K.hassan
  • M. Maktabifard
  • D. Derwis
  • J. Majtacz
  • J. Mąkinia

  - ENVIRONMENTAL RESEARCH - Year 2022

  The various forms of nitrogen (N), including ammonium (NH4+), nitrite (NO2−), and nitrate (NO3−), present in wastewaters can create critical biotic stress and can lead to hazardous phenomena that cause imbalances in biological diversity. Thus, biological nitrogen removal (BNR) from wastewaters is considered to be imperatively urgent. Therefore, anammox-based systems, i.e. partial nitrification and anaerobic ammonium oxidation (PN/anammox)...

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• Metabolism of 1α-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1α,20-dihydroxyvitamin D3

  Publication

  • R. Tuckey
  • Z. Janjetovic
  • W. Li
  • M. Nguyen
  • M. Zmijewski
  • J. Zjawiony
  • A. Slominski

  - The Journal of Steroid Biochemistry and Molecular Biology - Year 2008

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• Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.

  Publication

  • A. Potęga

  - Journal 0f Clinical Toxicolgy - Year 2014

  The knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...

• Diabetology & Metabolic Syndrome

  Journals

  ISSN: 1758-5996

• IJC Metabolic & Endocrine

  Journals

  ISSN: 2214-7624

• Nutrition and Metabolic Insights

  Journals

  ISSN: 1178-6388

• Metabolic Engineering Communications

  Journals

  eISSN: 2214-0301

• Endocrine and Metabolic Science

  Journals

  eISSN: 2666-3961

• Standard hypothyroid treatment did not restore proper metabolic response to carbohydrate

  Publication

  • A. Kozacz
  • G. Assis
  • U. Sanocka
  • A. Ziemba

  - ENDOCRINE - Year 2020

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• Comprehensive Metabolic Signature of Renal Dysplasia in Children. A Multiplatform Metabolomics Concept

  Publication

  • S. Macioszek
  • R. Wawrzyniak
  • A. Kranz
  • M. Kordalewska
  • W. Struck-Lewicka
  • D. Dudzik
  • M. Biesemans
  • M. Maternik
  • A. Żurowska
  • M. Markuszewski

  - Frontiers in Molecular Biosciences - Year 2021

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• Metabolic transformation of antitumor agent C1311 with various fractions of rat liver.

  Publication

  • A. Wiśniewska
  • Z. Mazerska
  • J. Konopa

  - Year 2004

  Wykazano, że enzymatyczna aktywacja jest konieczna dla aktywności bilogicznej pochodnej C-1311. Zbadano przemiany związku w obecności różnych frakcji enzymatycznych mikrosomalnych komórek wątroby szczura.Badania te wykazały, że związek C-1311 jest bardziej podatny na transformację pod wpływem frakcji aktywowanych enzymów mikrosomalnych (CYP1A, CYP2B, CYP3A i CYP4A) niż frakcji S9, cytozolowej czy mikrosomów nieaktywowanych. Związek...

• Disorders of iron metabolism - Female, 34 - Tissue image [4120730022894191]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Disorders of iron metabolism - Female, 34 - Tissue image [4120730022892091]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.