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Search results for: ADIPOKINES, CYTOKINES, ADRENAL TUMORS
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Experimental study on models of cylindrical steel tanks under mining tremors and moderate earthquakes
PublicationThe aim of the study is to show the results of complex shaking table experimental investigation focused on the response of two models of cylindrical steel tanks under mining tremors and moderate earthquakes, including the aspects of diagnosis of structural damage. Firstly, the impact and the sweep-sine tests have been carried out, so as to determine the dynamic properties of models filled with different levels of liquid. Then,...
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Numerical investigation on behaviour of cylindrical steel tanks during mining tremors and moderate earthquakes
PublicationCylindrical steel tanks are important components of industrial facilities. Their safety becomes a crucial issue since any failure may cause catastrophic consequences. The aim of the paper is to show the results of comprehensive FEM numerical investigation focused on the response of cylindrical steel tanks under mining tremors and moderate earthquakes. The effects of different levels of liquid filling, the influence of non-uniform...
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CYTOKINE & GROWTH FACTOR REVIEWS
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JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
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Brain Tumor Pathology
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AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
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BGA – BEST Gaming Arena
EventsBGA – BEST Gaming Arena jest największym wydarzeniem e-sportowym skierowanym do studentów, podczas którego odbywać się będą turnieje gier multiplayer, takich jak Counter Strike, League of Legends czy Hearthstone.
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ADRENAL GLAND, Adrenal gland, NOS - Female, 0 - Tissue image [413073001886751]
Open Research DataThis is the histopathological image of ADRENAL GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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ADRENAL GLAND, Adrenal gland, NOS - Male, 71 - Tissue image [12030630017649991]
Open Research DataThis is the histopathological image of ADRENAL GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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ADRENAL GLAND, Adrenal gland, NOS - Male, 2 - Tissue image [7040247104955291]
Open Research DataThis is the histopathological image of ADRENAL GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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ADRENAL GLAND, Adrenal gland, NOS - Male, 41 - Tissue image [3300730069468711]
Open Research DataThis is the histopathological image of ADRENAL GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Cellular Effects of Selected Unsymmetrical Bisacridines on the Multicellular Tumor Spheroids of HCT116 Colon and A549 Lung Cancer Cells in Comparison to Monolayer Cultures
PublicationMulticellular tumor spheroids are a good tool for testing new anticancer drugs, including those that may target cancer stem cells (CSCs), which are responsible for cancer progression, metastasis, and recurrence. Therefore, we applied this model in our studies of highly active antitumor unsymmetrical bisacridines (UAs). We investigated the cellular response induced by UAs in 2D and 3D cultures of HCT116 colon and A549 lung cancer...
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Comparison of peptide cancer signatures identified by mass spectrometry in serum of patients with head and neck, lung and colorectal cancers: Association with tumor progression
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Potentiation of the anti-tumour effects of Photofrin®-based photodynamic therapy by localized treatment with G-CSF
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Fluctuations of sodium, copper, zinc, iron and manganese in potato tubers in the organic and integrated production system
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Volatile organic compounds in gastrointestinal stromal tumour tissue originating from patient-derived xenografts
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Renal regulation of sodium, potassium and chloride balance in single- and twin-pregnant goats
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Renal denervation reduces office and ambulatory heart rate in patients with uncontrolled hypertension
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Ciliary phenotyping in renal epithelial cells in a cranioectodermal dysplasia patient with WDR35 variants
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A Single-Center Experience of Renal Transplantation in Elderly Patients: A Paired-Kidney Analysis
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Modifiable Areal Unit Problem: the issue of determining the relationship between microparameters and a macroparameter
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Novel Resveratrol-Based Substrates for Human Hepatic, Renal, and Intestinal UDP-Glucuronosyltransferases
PublicationTrans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anti-carcinogenic, and anti-aging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-Glucuronosyltransferases (UGTs). The aim of the current study was to test the hypothesis that the limited bioavailability of tRes can be improved by modifying its structure to create analogs...
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THE CONCEPT OF MODELING OF SNOW IMPACT ON THE STRUCTURE OF THE SUSPENDED TAURON ARENA ROOF IN CRACOW
PublicationThe article presents studies and numerical simulations on modeling snow influence on TAURON ARENA suspended roof structure in Cracow. The scope of work includes experimental tests, functions solutions taking into account various cases of snow impact according to PN and EC, as well as numerical simulations for the sport and entertainment arena in the Czyzyny district. The FEM roof structure model developed in the SOFISITK software...
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Pheochromocytoma, NOS - Male, 43 - Tissue image [9160729581058941]
Open Research DataThis is the histopathological image of ADRENAL GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Effect of foliar fertilization using micronutrient fertilizers on the content of nitrates(V), nitrites(III) in potato tubers
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Effect of biodynamic preparations on the content of some mineral elements and starch in tubers of three coloured potato cultivars
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Spectrum of Epithelial-Mesenchymal Transition Phenotypes in Circulating Tumour Cells from Early Breast Cancer Patients
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The Effect Of Reference Plane On Values Of Areal Surface Topography Parameters From Cylindrical Elements
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Investigating cellular location of aquaporins in the bovine kidney. A new view on renal physiology in cattle
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The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena
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Redefining The Modifiable Areal Unit Problem Within Spatial Econometrics, The Case of the Scale Problem
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Redefining the Modifiable Areal Unit Problem Within Spatial Econometrics, the Case of the Aggregation Problem
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Medical Image Dataset Annotation Service (MIDAS)
PublicationMIDAS (Medical Image Dataset Annotation Service) is a custom-tailored tool for creating and managing datasets either for deep learning, as well as machine learning or any form of statistical research. The aim of the project is to provide one-fit-all platform for creating medical image datasets that could easily blend in hospital's workflow. In our work, we focus on the importance of medical data anonimization, discussing the...
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Aberration of the enzymatic activity of Fhit tumor suppressor protein enhances cancer cell death upon photodynamic therapy similarly to that driven by wild-type Fhit
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Analysis of Circulating Tumor Cells in Patients with Non-Metastatic High-Risk Prostate Cancer before and after Radiotherapy Using Three Different Enumeration Assays
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Impedimetric Detection of Femtomolar Levels of Interleukin 6, Interleukin 8, and Tumor Necrosis Factor Alpha Based on Thermally Modified Nanotubular Titanium Dioxide Arrays
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DNA-reactive anticancer imidazoacridinone C-1311 is a new inhibitor of hypoxia-inducible factor 1 alpha, vascular endothelial growth factor and tumor angiogenesis
PublicationHypoxia-inducible factor 1 (HIF-1) plays a critical role for tumor adaptation to hypoxia and promotes angiogenesis. Antitumor imidazoacridinone C-1311 is a DNA reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor selected for phase II clinical trials for breast cancer. Here, we demonstrate the new mechanism of C-1311 action involving HIF-1a, vascular endothelial growth factor (VEGF) and angiogenesis as additional...
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Inhibition of T-type calcium channel disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
PublicationGlioblastoma multiforme (GBM) are brain tumors that are exceptionally resitant to both radio- and chemotherapy regimens and novel approaches to treatment are needed. T-type calcium channels are one type of low voltage-gated channel (LVCC) involved in embryonic cell proliferation and differentiation; however they are often over-expressed in tumors, including GBM. In this study, we found that inhibition of T-type Ca channels in GBM...
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THE DISTRIBUTION OF BIOACTIVE COMPOUNDS IN THE TUBERS OF ORGANICALLY GROWN JERUSALEM ARTICHOKE (HELIANTHUS TUBEROSUS L.) DURING THE GROWING PERIOD
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Adnexal tumor, benign - Male, 67 - Tissue image [9120729575166341]
Open Research DataThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Adnexal tumor, benign - Male, 48 - Tissue image [3300730069443171]
Open Research DataThis is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Development and validation of a model that includes two ultrasound parameters and the plasma D-dimer level for predicting malignancy in adnexal masses: an observational study
PublicationBackground: Pre-operative discrimination of malignant from benign adnexal masses is crucial for planning additional imaging, preparation, surgery and postoperative care. This study aimed to define key ultrasound and clinical variables and develop a predictive model for calculating preoperative ovarian tumor malignancy risk in a gynecologic oncology referral center. We compared our model to a subjective ultrasound assessment (SUA)...
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Arterial stiffness, body fat compartments, central hemodynamics, renal function and left atrial size
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First Report of the Global SYMPLICITY Registry on the Effect of Renal Artery Denervation in Patients With Uncontrolled Hypertension
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Renal artery denervation for treatment of patients with self-reported obstructive sleep apnea and resistant hypertension
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Ochrona odgromowa dużych obiektów sportowych na przykładzie stadionu PGE ARENA w Gdańsku
PublicationW artykule przedstawiono specyfikę ochrony dużych obiektów sportowych przed skutkami wyładowań atmosferycznych. Omówiono zasady ochrony tych obiektów przed bezpośrednim uderzeniem pioruna oraz sposoby ograniczenia przepięć powstających w instalacjach elektroenergetycznych oraz sterujących i pomiarowych zainstalowanych w takich obiektach. Wskazano konieczność indywidualnego rozwiązywania systemów ochronnych.
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Host and pathogen factors in Klebsiella pneumoniae upper urinary tract infections in renal transplant patients
PublicationPurpose . To analyse the role of virulence factors (VFs) and host in Klebsiella pneumoniae upper urinary tract infections (UTIs) in renal transplant (RTx) recipients. Methodology. Clinical and demographic data were registered prospectively. Phylogenetic background of K. pneumoniae isolates was analysed by PCR melting profiles (MP) and the following VFs genes: fimH-1, uge, kpn, ycfM, mrkD, rmpA, magA, hlyA, cnf-1, irp-1, irp-2,...
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Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models
PublicationBadania z użyciem modelu komórek nowotworu płuc A549 wykazały, że komórki te po traktowaniu lekami uszkadzającymi DNA zatrzymują proliferację i wchodzą w stan starzenia komórkowego. Jednak post-inkubacja tych komórek prowadzi do powrotu do stanu proliferacji małej frakcji komórek. Wykazaliśy, że frakcja ta związana jest z obecnością komórek pierwotnych nowotworu w populacji komórek A549. Powrót do stanu proliferacji komóek A549...
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Smart Approach for Glioma Segmentation in Magnetic Resonance Imaging using Modified Convolutional Network Architecture (U-NET)
PublicationSegmentation of a brain tumor from magnetic resonance multimodal images is a challenging task in the field of medical imaging. The vast diversity in potential target regions, appearance and multifarious intensity threshold levels of various tumor types are few of the major factors that affect segmentation results. An accurate diagnosis and its treatment demand strict delineation of the tumor affected tissues. Herein, we focus on...
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Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublicationMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...