Search
Filters
total: 969
-
Catalog
- Publications 574 available results
- Journals 11 available results
- Conferences 1 available results
- People 56 available results
- Projects 8 available results
- Research Equipment 1 available results
- e-Learning Courses 22 available results
- Events 1 available results
- Open Research Data 295 available results
Search results for: LDL RECEPTOR
-
Novel Tools for Comprehensive Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants
PublicationFamilial hypercholesterolemia (FH) is an autosomal-dominant disorder caused mainly by substitutions in the low-density lipoprotein receptor (LDLR) gene, leading to an increased risk of premature cardiovascular diseases. Tremendous advances in sequencing techniques have resulted in the discovery of more than 3000 variants of the LDLR gene, but not all of them are clinically relevant. Therefore, functional studies of selected variants...
-
Structural and Pharmacological Characterization of Phenylalanine-Based AMPA Receptor Antagonists at Kainate Receptors
Publication -
Cathepsin G activity lowers plasma LDL and reduces atherosclerosis
Publication -
Nuclear Receptor Signaling
Journals -
RECEPTORS & CHANNELS
Journals -
Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors—molecular dynamics study of the activated receptor–vasopressin–Gα systems
Publication -
Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient
Publication -
Molecular Docking-Based Study of Vasopressin Analogues Modified at Positions 2 and 3 with N-Methylphenylalanine: Influence on Receptor-Bound Conformations and Interactions with Vasopressin and Oxytocin Receptors
Publication -
Semantic web services in L2L.
PublicationOgromnym problemem współpracy istniejących bibliotek cyfrowych w kontekście używanych protokołów jest albo ograniczenie funkcjonalności systemu albo łamanie istniejących standardów komunikacji powodując utratę możliwości kooperacji z wieloma systemami. Technologia semantycznych usług sieciowych może zmienić tę sytuację przez umożliwienie komunikacji z usługą bez wcześniejszej znajmości protokołu stosowanego przez bibliotekę. W...
-
LDA journal
Journals -
Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: Molecular dynamics simulation of the agonist-bound state in the membrane–aqueous system
Publication -
SDL i prosty scheduler - zastosowania.
PublicationRozdział przedstawia uzupełnienia, usprawnienia i zastosowania prostego schedulera zaproponowanego w [1]. Podstawowym uzupełnieniem jest powiązanie funkcji schedulera z językiem specyfikacji protokołów telekomunikacyjnych SDL [2]. Pokazano na czym polega problem w odmierzaniu czasu w ''procesach'' obsługiwanych przez scheduler oraz istotne ograniczenia mechanizmu odmierzania czasu w systemach warstwowych. Zaproponowano rozwiązania...
-
Usługi Webowe dla zastosowań L2L.
PublicationPrzedstawiono problemy komunikacji pomiędzy systemami informatycznymi dla sektora B2B. Jako rozwiązanie zaproponowano technologię Usług Webowych (Web Service). Omówiono jej koncepcję oraz przykładową implementację przy pomocy protokołów: HTTP, SOAP czy WSDL. Problemy związane z integracją aplikacji zilustrowano na przykładzie aplikacji tworzonych w ramach w ramach projektu PBI. Wskazano dalszy możliwy kierunek rozwoju tego...
-
Study of New Oxytocin Antagonist Barusiban (Fe200 440) Affinity Toward Human Oxytocin Receptor Versus Vasopressin V1a and V2 Receptors - Molecular Dynamics Simulation in POPC Bilayer
Publication -
Vasopressin V2 receptor/bioligand interactions
Publication -
Quantitative chirality in the binding of androgens to their receptor
Publication -
Angiotensin receptor blockers and endpoint protection
Publication -
Journal of Receptor Ligand and Channel Research
Journals -
Diagnostic Models and Estimators for LDI in Transmission Pipelines
PublicationThis article considers and compares four analytical models of the pipeline flow process for leak detection and location tasks. The synthesis of these models is briefly outlined. Next, the methodology for generating data and diagnosing pipes is described, as well as experimental settings, assumptions and implemented scenarios. Finally, the quality of model-based diagnostic estimators has been evaluated for their bias, standard deviations...
-
Managing distributed architecture with Extendet WS-CDl
PublicationZaprezentowano problem wykorzystania języka WSCDL w warstwie zarzadzania usługami w architekturze systemu rozproszonego. Zaproponowano rozszerzenie modelu CDLExt uwzględniając istotne charakterystyki usług. Skoncentrowano się na zależności między usługami a innymi artyfaktami IT oraz określono atrybuty QoS wynikajace z tych zależności. Zaprezentowano implementację tego modelu oraz dalsze kierunki rozwoju CDLExt.
-
Estrogen receptor 2 polymorphism in idiopathic scoliosis
Publication -
Affinity of fentanyl and its derivatives for the σ1-receptor
Publication -
Molecular Modeling of the Neurohypophyseal Receptor/Atosiban Complexes
Publication -
Selective detection of F- by chromogenic tetrazole receptor
PublicationA chromogenic anion host 4, containing two amide functionalities linked to azo dye and tetrazole rings was synthesized and its complexes with various anions were investigated. The results show that receptor 4 can recognize selectively biologically important F- ion. The binding affinity for F- was investigated by naked-eye colour change, UV-Vis and 1H NMR spectroscopy. Addition F- ion in CH3CN and DMSO to receptor 4 cause a colour...
-
Activation of Metabotropic Glutamate Receptor (mGlu2) and Muscarinic Receptors (M1, M4, and M5), Alone or in Combination, and Its Impact on the Acquisition and Retention of Learning in the Morris Water Maze, NMDA Expression and cGMP Synthesis
PublicationThe Morris water maze (MWM) is regarded as one of the most popular tests for detecting spatial memory in rodents. Long-term potentiation and cGMP synthesis seem to be among the crucial factors involved in this type of learning. Muscarinic (M1, M4, and M5 receptors) and metabotropic glutamate (mGlu) receptors are important targets in the search for antipsychotic drugs with the potency to treat cognitive disabilities associated with...
-
Moving out of CF3‐Land: Synthesis, Receptor Affinity, and in silico Studies of NK1 Receptor Ligands Containing a Pentafluorosulfanyl (SF5) Group
Publication -
Transfer. Reception studies
Journals -
LDI issue brief
Journals -
Using UML/WS-CDL for modelling negotiation scenarios
PublicationW celu usprawnienia realizacji przedsięwzięć ludzkich w Internecie potrzebne jest zdefiniowanie reguł i procedur komunikacji pomiędzy uczestnikami. Scenariusze przedsięwzięć mogą być wyrażane w językach opisu choreografii. Artykuł prezentuje metodologię tworzenia scenariuszy w języku WS-CDL oraz wyniki eksperymentów polegających na przeprowadzeniu negocjacji w Internecie z wykorzystaniem różnych scenariuszy negocjacyjnych.
-
Targeting melanocortin receptor type 1 with small peptides
Publication -
Vitamin D receptor(s): In the nucleus but also at membranes?
Publication -
Trend research of vitamin D receptor: Bibliometric analysis
Publication -
Estrogen Receptor 2 Gene Polymorphism in Idiopathic Scoliosis
Publication -
Towards β-selectivity in functional estrogen receptor antagonists
PublicationBased on the benzo[b]naphtho[1,2-d]furan and benzo[b]naphtho[1,2-d]thiophene frameworks, a series of ligands with different basic side chains (BSCs) has been synthesized and pharmacologically evaluated. Also, their binding modes have been modelled using docking techniques. It was found that the introduction of a BSC in these systems brings about a decrease of affinity for both estrogen receptors α and β in an in vitro competitive...
-
Gαi-derived peptide binds the µ-opioid receptor
Publication -
Molecular dynamics of fentanyl bound to μ-opioid receptor
Publication -
Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands
Publication -
New clicked full agonists of the estrogen receptor β
PublicationA click chemistry approach was used to synthesize a series of 1,4-diaryl-substituted 1,2,3-triazoles designed to behave as estrogen receptor (ER) ligands. We studied their affinities for both receptors α and β, their agonist activities in a cell-based luciferase reporter assay and their effect on the proliferation of the hormone-dependent MCF-7 cell line. We found two compounds (3a and 3c) that behave as selective full agonists...
-
Predictive control of active filter system with LCL coupling circuit
Publication -
RORα is not a receptor for melatonin (response to DOI 10.1002/bies.201600018)
Publication -
Molecular Dynamics of a Vasopressin V2 Receptor in a Phospholipid Bilayer Membrane
Publication -
The neuroprotective activity of new phenylalanine-based AMPA receptor antagonists
Publication -
3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands
Publication -
Tuning the sumanene receptor structure towards the development of potentiometric sensors
Publication -
Vitamin D receptor gene polymorphisms in Alzheimer's disease patients
Publication -
Estrogen Receptors in Cell Membranes: Regulation and Signaling
Publication -
Evidence for sex steroid receptors in feline brainstem
Publication -
Pyridylmethylsilanes as dicarboxyacid receptors: Experimental and theoretical study
Publication -
Olfactory receptor-based biosensors as potential future tools in medical diagnosis
PublicationThe detection of biomarkers is the future of non-invasive medical diagnosis and screening. Discovery and identification of reliable disease specific volatile organic compounds is dependent on repeatable, accurate analysis of trace level gaseous analytes mainly in breath samples. Natural variety of the olfactory systems and the compounds capable of gas molecules binding creates wide possibilities of acquisition and implementation...
-
Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders
Publication