Rok 2021

• PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke

  Publikacja

  • J. Mazuryk
  • I. Puchalska
  • K. Koziński
  • M. J. Ślusarz
  • J. Ruczyński
  • P. Rekowski
  • P. Rogujski
  • R. Płatek
  • M. B. Wiśniewska
  • A. Piotrowski... i 7 innych

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Rok 2021

  Ischemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...

  Pełny tekst do pobrania w portalu

Rok 2019

• Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities

  Publikacja

  • N. Ptaszyńska
  • K. Gucwa
  • K. Olkiewicz
  • A. Łȩgowska
  • J. Okońska
  • J. Ruczyński
  • A. Gitlin-Domagalska
  • D. Dȩbowski
  • S. Milewski
  • K. Rolka

  - ACS Chemical Biology - Rok 2019

  Recent studies have shown that modified human lactoferrin 20−31 fragment, named HLopt2, possesses antibacterial and antifungal activity. Thus, we decided to synthesize and evaluate the biological activity of a series of conjugates based on this peptide and one of the antimicrobials with proven antibacterial (ciprofloxacin, CIP, and levofloxacin, LVX) or antifungal (fluconazole, FLC) activity. The drugs were covalently connected...

  Pełny tekst do pobrania w serwisie zewnętrznym

• Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse

  Publikacja

  • P. Sass
  • P. Sosnowski
  • J. Podolak-Popinigis
  • B. Górnikiewicz
  • J. Kamińska
  • M. Deptuła
  • E. Nowicka
  • A. Wardowska
  • J. Ruczyński
  • P. Rekowski... i 12 innych

  - EBioMedicine - Rok 2019

  Background:Most studies on regenerative medicine focus on cell-based therapies and transplantations.Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensivelyinvestigated in regenerative research. It is known that healing potential decreases with development and devel-opmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerativecapacity.Methods:We...

  Pełny tekst do pobrania w portalu