Wyszukiwarka
Julia Pakuła
Zatrudnienie
- Doktorant w Gdansk University of Technology
Obszary badawcze
Publikacje
Filtry
wszystkich: 2
Katalog Publikacji
Rok 2025
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The interactions of Pu22 G-quadruplex, derived from c-MYC promoter sequence, with antitumor acridine derivatives – an NMR/MD combined study
PublikacjaUnsymmetrical bisacridines (UAs) represent a novel class of anticancer agents that exhibit significant antitumor activity against a wide range of cancer cell lines and solid tumors in vivo. UAs consist of two different acridine-based ring systems, which are connected by an aminoalkyl linker. Recent studies have demonstrated that UAs can suppress the c-MYC protooncogene, which is overexpressed in many tumor types. As a proposed...
Rok 2024
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NMR-Based Structural Insight into DNA G-Quadruplex
PublikacjaEmerging as a promising area in anticancer research, noncanonical DNA structures such as G-quadruplexes are studied using NMR spectroscopy. NOESY spectra reveals crucial interactions between ligands and G-quadruplexes, helping to understand non-covalent binding mechanisms. This knowledge is essential for rational drug design targeting these structures.
wyświetlono 364 razy