Rok 2024

• CHEMOTHERAPY-MEDIATED COMPLICATIONS OF WOUND HEALING. AN UNDERSTUDIED SIDE EFFECT

  Publikacja

  • P. Słonimska
  • P. Sachadyn
  • J. Zieliński
  • M. Skrzypski
  • M. Pikuła

  - Advances in Wound Care - Rok 2024

  Significance: Chemotherapy is a primary method to treat cancer, but while cytotoxic drugs are designed to target rapidly dividing cancer cells, they can also affect other cell types, including dermal cells and macrophages involved in wound healing, which often leads to the development of chronic wounds. The situation becomes even more severe when chemotherapy is combined with surgical tumor excision. Recent advances: Despite its...

  Pełny tekst do pobrania w portalu

• Circulating miRNA profiles and the risk of hemorrhagic transformation after thrombolytic treatment of acute ischemic stroke: a pilot study

  Publikacja

  • M. Stańczak
  • A. Wyszomirski
  • P. Słonimska
  • B. Kołodziej
  • B. Jabłoński
  • A. Stanisławska-Sachadyn
  • B. Karaszewski

  - Frontiers in Neurology - Rok 2024

  Background: Hemorrhagic transformation (HT) in acute ischemic stroke is likely to occur in patients treated with intravenous thrombolysis (IVT) and may lead to neurological deterioration and symptomatic intracranial hemorrhage (sICH). Despite the complex inclusion and exclusion criteria for IVT and some useful tools to stratify HT risk, sICH still occurs in approximately 6% of patients because some of the risk factors for this...

  Pełny tekst do pobrania w serwisie zewnętrznym

• From Bioink to Tissue: Exploring Chitosan-Agarose Composite in the Context of Printability and Cellular Behaviour

  Publikacja

  • S. Mania
  • A. Banach-Kopeć
  • N. Maciejewska
  • K. Czerwiec
  • M. Deptuła
  • P. Słonimska
  • J. Baczyński-Keller
  • M. Pikuła
  • P. Sachadyn
  • R. Tylingo

  - MOLECULES - Rok 2024

  This study presents an innovative method for producing thermosensitive bioink from chitosan hydrogels saturated with carbon dioxide and agarose. It focuses on a detailed characterisation of their physicochemical properties and potential applications in biomedicine and tissue engineering. The ORO test approved the rapid regeneration of the three-dimensional structure of chitosan–agarose composites in a unidirectional bench press...

  Pełny tekst do pobrania w serwisie zewnętrznym

• Isolation of Human Progenitor Epidermal Cells on Collagen Type IV and Analysis of Their Markers with Flow Cytometry and PCR Methods

  Publikacja

  • M. Deptula
  • M. Zawrzykraj
  • P. Słonimska
  • M. Pikuła

  - Rok 2024

  Epidermal stem cells, located in the skin, together with keratinocytes are transplanted in regenerative therapies, e.g., for the treatment of burns or other wounds. Here, we describe the protocol of their enzymatic isolation from human skin. It includes separation of the epidermis form the dermis by incubation with dispase followed by cell isolation for epidermis by digestion with trypsin. Cell isolated with this method can be...

  Pełny tekst do pobrania w serwisie zewnętrznym

Rok 2022

• Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

  Publikacja

  • P. Sosnowski
  • P. Sass
  • P. Słonimska
  • R. Płatek
  • J. Kamińska
  • J. Baczyński-Keller
  • P. Mucha
  • G. Peszyńska-Sularz
  • A. Czupryn
  • M. Pikuła... i 5 innych

  - Pharmaceuticals - Rok 2022

  The ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...

  Pełny tekst do pobrania w portalu