- Akronim projektu:
- Program finansujący:
- Narodowe Centrum Badań i Rozwoju (NCBR) (The National Centre for Research and Development)
- STRATEGMED3/306853/9/NCBR/2017 z dnia 2017-05-17
- Okres realizacji:
- 2017-04-01 - 2021-12-31
- Kierownik projektu:
- prof. dr hab. inż. Maciej Bagiński
- Realizowany w:
- Katedra Technologii Leków i Biochemii
- Instytucje zewnętrzne
biorące udział w projekcie:
- CU-CONSULT Sp. z o.o. (Polska)
- Gdański Uniwersytet Medyczny (Polska)
- Uniwersytet Gdański (Polska)
- Instytut Immunologii i Terapii Doświadczalnej, PAN we Wrocławiu (Polska)
- Instytut Biologii Molekularnej, PAN w Warszawie (Polska)
- Szpitale Wojewódzkie w Gdyni (Polska)
- Innovabion Sp. z o.o. (Polska)
- Typ zgłoszenia:
- Krajowy Program Badawczy
- Projekt krajowy
- Politechnika Gdańska
Publikacje powiązane z tym projektem
Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesisPublikacja
The acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...
Novel chalcone-derived pyrazoles as potential therapeutic agents for the treatment of non-small cell lung cancerPublikacja
Lung cancer is considered to account for approximately one-fifth of all malignant tumor-related deaths worldwide and is therefore one of the most lethal malignancies. Pyrazole scaffold possesses a wide range of biological and pharmacological activities, which play important roles in medicinal chemistry. The present study reports the synthesis and in vitro biological characterization of nine pyrazoles derived from chalcones as potential...
Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitorPublikacja
Inositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irrevocable stress, proapoptotic gene expression is induced to promote cell death. One of the three signaling stressors, IRE1α is an serine/threonine-protein kinase/endoribonuclease (RNase) that...
In silico design of telomerase inhibitors.Publikacja
Telomerase is a reverse transcriptase enzyme involved in DNA synthesis at the end of linear chromosomes. Unlike in most other cells, telomerase is reactivated most cancerous cells and, therefore, has become a promising new anticancer target. Despite extensive research, direct telomerase inhibitors have yet not been introduced to the clinics because of the complexity of this enzyme. Structures of this protein from simple organisms...
Photosensitive and pH-dependent activity of pyrazine-functionalized carbazole derivative as promising antifungal and imaging agentPublikacja
Carbazole skeleton plays a significant role as a structural scaffold of many pharmacologically active compounds. Pyrazine-functionalized carbazole derivative was constructed by coupling 2-amino-5-bromo-3-methylaminepyrazine (ABMAP) into 3 and 6 positions of the carbazole ring. Multi-experimental methods were used, e.g., potentiometric, spectroscopic (ATR, UV, XRD powder,1H and13C NMR), electrochemical (cyclic voltammetry), and...
Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule StabilizationPublikacja
Rational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often dicult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing aordability of genome-wide next-generation technologies now provides an excellent opportunity to understand a compound’s diverse eects...
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