Analysis of heat transfer and AuNPs-mediated photo-thermal inactivation of E. coli at varying laser powers using single-phase CFD modeling

Aimad Koulali; Paweł Ziółkowski; Piotr Radomski; Luciano Sio De; Zieliński Jacek; Cristina María Nevárez Martínez; Dariusz Mikielewicz

doi:10.1108/hff-04-2024-0252

Analysis of heat transfer and AuNPs-mediated photo-thermal inactivation of E. coli at varying laser powers using single-phase CFD modeling

Abstrakt

Purpose In the wake of the COVID-19 pandemics, the demand for innovative and effective methods of bacterial inactivation has become a critical area of research, providing the impetus for this study. The purpose of this research is to analyze the AuNPs-mediated photothermal inactivation of E. coli. Gold nanoparticles irradiated by laser represent a promising technique for combating bacterial infection that combines high-tech and scientific progress. The intermediate aim of the work was to present the calibration of the model with respect to the gold nanorods experiment. The purpose of this work is to study the effect of initial concentration of E. coli bacteria, the design of the chamber and the laser power on heat transfer and inactivation of E. coli bacteria. Design/methodology/approach Using the CFD simulation, the work combines three main concepts. 1. The conversion of laser light to heat has been described by a combination of three distinctive approximations: a- Discrete particle integration to take into account every nanoparticle within the system, b- Rayleigh-Drude approximation to determine the scattering and extinction coefficients and c- Lambert–Beer–Bourger law to describe the decrease in laser intensity across the AuNPs. 2. The contribution of the presence of E. coli bacteria to the thermal and fluid-dynamic fields in the microdevice was modeled by single-phase approach by determining the effective thermophysical properties of the water-bacteria mixture. 3. An approach based on a temperature threshold attained at which bacteria will be inactivated, has been used to predict bacterial response to temperature increases. Findings The comparison of the thermal fields and temporal temperature changes obtained by the CFD simulation with those obtained experimentally confirms the accuracy of the light-heat conversion model derived from the aforementioned approximations. The results show a linear relationship between maximum temperature and variation in laser power over the range studied, which is in line with previous experimental results. It was also found that the temperature inside the microchamber can exceed 55 °C only when a laser power higher than 0.8 W is used, so bacterial inactivation begins.

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Autorzy (7)

Aimad Koulali dr
Paweł Ziółkowski dr inż.
Piotr Radomski mgr inż.
Luciano Sio De
- University of Rome La Sapienza
Zieliński Jacek prof.
- Gdański Uniwersytet Medyczny
Cristina María Nevárez Martínez
- Uniwersytet Gdański
Dariusz Mikielewicz prof. dr hab. inż.

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Kategoria:

Publikacja w czasopiśmie

Typ:

artykuły w czasopismach dostępnych w wersji elektronicznej [także online]

Opublikowano w:

INTERNATIONAL JOURNAL OF NUMERICAL METHODS FOR HEAT & FLUID FLOW
ISSN: 0961-5539

Język:

angielski

Rok wydania:

2024

Opis bibliograficzny:

Koulali A., Ziółkowski P., Radomski P., Sio De L., Jacek Z., Nevárez Martínez C. M., Mikielewicz D., Analysis of heat transfer and AuNPs-mediated photo-thermal inactivation of E. coli at varying laser powers using single-phase CFD modeling, INTERNATIONAL JOURNAL OF NUMERICAL METHODS FOR HEAT & FLUID FLOW, 2024,10.1108/HFF-04-2024-0252

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