CFD COUPLING OF VOF MODEL WITH ARRHENIUS EQUATION FOR ANALYSIS OF LASER-INDUCED THERMAL DEACTIVATION OF E. COLI

Aimad Koulali; Piotr Radomski; L. De Sio; Dariusz Mikielewicz; Paweł Ziółkowski

doi:10.1615/tfec2024.sim.051258

CFD COUPLING OF VOF MODEL WITH ARRHENIUS EQUATION FOR ANALYSIS OF LASER-INDUCED THERMAL DEACTIVATION OF E. COLI

Abstrakt

Understanding bacterial deactivation at the micro-scale, particularly with E. coli, is crucial for advancing microbiology and has promising applications in biomedical research. In this research contribution, we investigate the thermal inactivation of E. coli bacteria using gold nanoparticles irradiated by a green 1-W laser within a microfluidic chamber. The microfluidic device comprises a fluidic chamber filled with a thin film of water and air (1 mm thick). The chamber is constructed with 1 mm PDMS coating on the top and side walls, and 1 mm borosilicate glass on the bottom. Computational Fluid Dynamics (CFD) calculations are executed using ANSYS Fluent software employing the Volume of Fluid (VOF) multi-phase model. Bacterial deactivation is described by a first-order kinetic model, while the Arrhenius equation is employed to define the decay coefficient. The light-heat conversion is modeled using a literature-based approach, validated against experimental data. Our findings affirm the efficacy of the proposed physical model (laser + gold nanoparticles) for bacterial inactivation. Additionally, we propose an innovative approach by coupling bacterial inactivation equations and VOF model, opening avenues for further applications in the field.

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Autorzy (5)

Aimad Koulali dr
Piotr Radomski mgr inż.
L. De Sio
- Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome, Latina, Italy
Dariusz Mikielewicz prof. dr hab. inż.
Paweł Ziółkowski dr inż.

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publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)

Język:

angielski

Rok wydania:

2024

Opis bibliograficzny:

Koulali A., Radomski P., De Sio L., Mikielewicz D., Ziółkowski P.: CFD COUPLING OF VOF MODEL WITH ARRHENIUS EQUATION FOR ANALYSIS OF LASER-INDUCED THERMAL DEACTIVATION OF E. COLI// / : , 2024,

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