Assessing Acute Toxicity and Endocrine Disruption Potential of Selected Packages Internal Layers Extracts
The focus of the present study is migration of toxic substances from food contact materials and its actual influence on the health of the final consumer. Two food packagings (metal cans, TetraPack®) and five simulants medias (water, ethanol, acetic acid, DMSO, artificial saliva) were selected for simulation studies. For assessment of acute toxicity and endocrine disruption potential of extract samples, two biotests (Microtox® and XenoScreen YES/YAS) were performed. Multi-factor analysis of variation (MANOVA) was used to evaluate the effects of the three main factors - solvent, temperature, contact time and their interactions on the respected dependent variable (acute toxicity or estrogen disruption potential).
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