Dissociative Electron Attachment to 5-Iodo-4-thio-2′-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells - Publikacja - MOST Wiedzy

Twoje konto

zaloguj

Wyszukiwarka

Dissociative Electron Attachment to 5-Iodo-4-thio-2′-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells

Abstrakt

In the search for effective radiosensitizers for tumor cells, halogenated uracils have attracted more attention due to their large cross section for dissociation upon the attachment of low-energy electrons. In this study, we investigated dissociative electron attachment (DEA) to 5-iodo-4-thio-2'-deoxyuridine, a potential radiosensitizer using a crossed electron-molecule beam experiment coupled with quadrupole mass spectrometry. The experimental results were supported by calculations on the threshold energies of formed anions and transition state calculations. We show that low-energy electrons with kinetic energies near 0 eV may effectively decompose the molecule upon DEA. The by far most abundant anion observed corresponds to the iodine anion (I-). Due to the associated bond cleavage, a radical site is formed at the C5 position, which may initiate strand break formation if the molecule is incorporated into a DNA strand. Our results reflect the conclusion from previous radiolysis studies with the title compound, suggesting its potential as a radiosensitizer.

Cytowania

  • 2

    CrossRef

  • 0

    Web of Science

  • 2

    Scopus

Autorzy (8)

Cytuj jako

Pełna treść

pobierz publikację
pobrano 5 razy
Wersja publikacji
Accepted albo Published Version
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1021/acs.jpclett.3c02219
Licencja
Creative Commons: CC-BY otwiera się w nowej karcie

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
Journal of Physical Chemistry Letters nr 14, strony 8948 - 8955,
ISSN: 1948-7185
Język:
angielski
Rok wydania:
2023
Opis bibliograficzny:
Saqib M., Arthur-Baidoo E., Izadi F., Szczyrba A., Datta M., Demkowicz S., Rak J., Denifl S.: Dissociative Electron Attachment to 5-Iodo-4-thio-2′-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells// Journal of Physical Chemistry Letters -,iss. 14 (40) (2023), s.8948-8955
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1021/acs.jpclett.3c02219
Źródła finansowania:
  • COST_FREE
Weryfikacja:
Politechnika Gdańska

wyświetlono 39 razy

Publikacje, które mogą cię zainteresować

Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2′-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment

  • F. Izadi,
  • A. Szczyrba,
  • M. Datta
  • + 4 autorów
2023

Hydroperoxyl radical and formic acid formation from common DNA stabilizers upon low energy electron attachment

2018

Intramolecular Proton Transfer in the Radical Anion of Cytidine Monophosphate Sheds Light on the Sensitivities of Dry vs Wet DNA to Electron Attachment-Induced Damage

  • L. Chomicz-Mańka,
  • A. Czaja,
  • K. Falkiewicz
  • + 11 autorów
2023

Carboxylation Enhances Fragmentation of Furan upon Resonant Electron Attachment

2020
Meta Tagi