Fragmentomic analysis of biopeptides in silico released from milk proteins - Publikacja - MOST Wiedzy

Twoje konto

zaloguj

Wyszukiwarka

Fragmentomic analysis of biopeptides in silico released from milk proteins

Abstrakt

The fragmentomic-assisted method was employed to predict the biological potential of peptides derived from milk proteins hydrolyzed by papain and bromelain. Firstly, protein sequences were acquired from the BIOPEP-UWM database and then hydrolyzed by the above enzymes using a BIOPEP-UWM tool called “Enzyme(s) action”. The released peptides were defined as parent peptides and further analyzed for the presence of shorter peptidic regions with documented bioactivity as well as their likelihood to be bioactive. The results revealed the bioactive potential of the released parent peptides. β-Casein was found as the best source of biopeptides. Although this finding is consistent with literature data, the new parent peptide i.e., PVQPFTESQSLTLTDVENLHLPPLLLQSWMHQPHQPLPPTVMFPPQSVLSLSQSK, produced by the action of bromelain might be considered as a new strategic zone due to the presence of multi-active regions. Some parent peptides theoretically produced from milk proteins turned out to be fully bioactive. Despite the usefulness of the tools for peptide bioactivity prediction, the critical thinking while planning the application of such data in future experiments would thus appear to be a worthwhile line of inquiry.

Cytowania

  • 0

    CrossRef

  • 0

    Web of Science

  • 1

    Scopus

Autorzy (2)

Cytuj jako

Pełna treść

pobierz publikację
pobrano 74 razy
Wersja publikacji
Accepted albo Published Version
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.31648/pjns.7726
Licencja
Creative Commons: CC-BY-NC-ND otwiera się w nowej karcie

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
POLISH JOURNAL OF NATURAL SCIENCES nr 37, strony 125 - 147,
ISSN: 1643-9953
Język:
angielski
Rok wydania:
2022
Opis bibliograficzny:
Iwaniak A., Taraszkiewicz A.: Fragmentomic analysis of biopeptides in silico released from milk proteins// POLISH JOURNAL OF NATURAL SCIENCES -Vol. 37,iss. 1 (2022), s.125-147
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.31648/pjns.7726
Źródła finansowania:
  • Projekt finansowany w ramach programu Ministra Edukacji i Nauki pod nazwą "Regionalna Inicjatywa Doskonałości" w latach 2019-2022, nr projektu 010/RID/2018/19, kwota finansowania 12 000 000 PLN
  • Projekt finansowany w ramach funduszu Uniwersytetu Warmińsko-Mazurskiego w Olsztynie, nr tematu 17.610.014-110
Weryfikacja:
Politechnika Gdańska

wyświetlono 134 razy

Publikacje, które mogą cię zainteresować

Prediction of Bioactive Peptides From Chicken Feather and Pig Hair Keratins Using In Silico Analysis Based on Fragmentomic Approach

2022

Chicken feather keratin as a source of bioactive peptides useful in prevention of metabolic disorders – in silico and in vitro hydrolysis

2021

The biological role of prolyl oligopeptidase and the procognitive potential of its peptidic inhibitors from food proteins

2024

Rapid Characterization of the Human Breast Milk Lipidome Using a Solid-Phase Microextraction and Liquid Chromatography-Mass Spectrometry-Based Approach.

2017
Meta Tagi