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Abstrakt
Bioactive materials may be applied in tissue regeneration, and an example of such materials are wound dressings, which are used to accelerate skin healing, especially after trauma. Here, we proposed a novel dressing enriched by a bioactive component. The aim of our study was to prepare and characterize poly(vinyl alcohol) films modified with strontium titanate nanoparticles. The physicochemical properties of films were studied, such as surface free energy and surface roughness, as well as the mechanical properties of materials. Moreover, different biological studies were carried out, like in vitro hemo- and cyto-compatibility, biocidal activity, and anti-biofilm formation. Also, the degradation of the materials’ utilization possibilities and enzymatic activity in compost were checked. The decrease of surface free energy, increase of roughness, and improvement of mechanical strength were found after the addition of nanoparticles. All developed films were cyto-compatible, and did not induce a hemolytic effect on the human erythrocytes. The PVA films containing the highest concentration of STO (20%) reduced the proliferation of Eschericha coli, Pseudomonas aeruginosa, and Staphylococcus aureus significantly. Also, all films were characterized by surface anti-biofilm activity, as they significantly lowered the bacterial biofilm abundance and its dehydrogenase activity. The films were degraded by the compost microorganism. However, PVA with the addition of 20%STO was more difficult to degrade. Based on our results, for wound dressing application, we suggest using bioactive films based on PVA + 20%STO, as they were characterized by high antibacterial properties, favorable physicochemical characteristics, and good biocompatibility with human cells.
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Autorzy (9)
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Beata Kaczmarek-Szczepańska dr
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Lidia Zasada
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Maria Swiontek Brzezinska
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Anna Michno dr hab. n. med.
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Anna Ronowska dr hab. n. med.
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Magdalena Ciesielska
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Ganna Kovtun
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M. Teresa Cuberes
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Pełna treść
- Wersja publikacji
- Accepted albo Published Version
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/polym16040484
- Licencja
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach
- Opublikowano w:
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Polymers
nr 16,
ISSN: 2073-4360 - Język:
- angielski
- Rok wydania:
- 2024
- Opis bibliograficzny:
- Kaczmarek-Szczepańska B., Zasada L., Wekwejt M., Brzezinska M. S., Michno A., Ronowska A., Ciesielska M., Kovtun G., Cuberes M. T.: PVA-Based Films with Strontium Titanate Nanoparticles Dedicated to Wound Dressing Application// Polymers -,iss. 4 (2024), s.484-
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/polym16040484
- Źródła finansowania:
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- Grant number 282/2021 IDUB (B.K.-S.), Ref. 2022-GRIN-34226 (Plan Propio UCLM co-funded 85% by FEDER), 2022-UNIVERS-11036, ref. 2022-POST-20987 (G.K.)
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 73 razy
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