Abstrakt

Many people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and other diseases. Therefore, many scientists seek new, more effective, more selective and less toxic drugs. Acridine/acridone derivatives constitute a class of compounds with a broad spectrum of biological activity and are of great interest to scientists. Todate, many acridine/acridone analogues have been obtained,which, inter alia, exhibit antitumour antimicrobial and antiviral activities and are applicable in the treatment of Alzheimer's disease. However, inmanycases, the irclinical application is limited and excluded because of side effects. In this survey, we describe acridine and acridone derivatives reported since 2013, methods of their synthesis and their potential clinical applications.

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Autorzy

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  Monika Gensicka-Kowalewska dr inż.

  • Katedra Chemii Organicznej
  • Wydział Chemiczny
  • Politechnika Gdańska
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  Grzegorz Cholewiński dr hab. inż.

  • Katedra Chemii Organicznej
  • Wydział Chemiczny
  • Politechnika Gdańska
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  Krystyna Dzierzbicka prof. dr hab. inż.

  • Katedra Chemii Organicznej
  • Wydział Chemiczny
  • Politechnika Gdańska