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Wyniki wyszukiwania dla: DRA GENE CLUSTER
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Role of miR-15b/16–2 cluster network in endometrial cancer: An in silico pathway and prognostic analysis
PublikacjaEndometrial cancer (EC) is the second most common cancer in women. A large number of human cancers exhibit dysregulation of microRNA expression including EC. MiR-15b/16–2 is one of the best-known miRNA clusters that is expressed in many types of cancer tissues. Herein, we analyzed the expression of individual miR-15b/16–2 cluster members, its paralogues, and their target network analysis, as well as their prognostic significance...
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Whole-genome sequencing and antimicrobial potential of bacteria isolated from Polish honey
PublikacjaThe aim of this study was the whole-genome analysis and assessment of the antimicrobial potential of bacterial isolates from honey harvested in one geographical location—the north of Poland. In total, 132 strains were derived from three honey samples, and the antimicrobial activity of CFAM (cell-free after-culture medium) was used as a criterion for strain selection and detailed genomic investigation. Two of the tested isolates...
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Identification of antigen Ag43 in uropathogenic Escherichia coli Dr+ strains and defining its role in the pathogenesis of urinary tract infections
PublikacjaUrinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common bacterial infectious diseases in the developed world. The urovirulence of UPEC is mainly associated with the surface-exposed fimbrial adhesins and adhesins of the autotransporter (AT) family. The best studied of theses proteins is antigen 43 (Ag43) mediating cell aggregation, adhesion and biofilm development as the causes of...
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Characterisation of Escherichia coli isolates from the blood of haematological adult patients with bacteraemia: translocation from gut to blood requires the cooperation of multiple virulence factors
PublikacjaThe aim of the study was to investigate whether there are unique pathotypes of Escherichia coli capable of transmission from the gastrointestinal tract to the vascular bed. The study included E. coli strains isolated from clinical materials collected from 115 patients suffering from haematologic malignancies diagnosed with bacteraemia. The genotyping techniques established that 89 E. coli isolates from the blood had the same genotype...
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Knowledge Flows in Cluster Organizations
PublikacjaThis paper aims to identify knowledge flows in cluster organizations (COs). On the basis of a literature analysis on knowledge flows and cluster organizations, the following research question was formulated: What kind of knowledge flows can be identified in cluster organizations and what is their main characteristics? The paper is based on a literature analysis and Grounded Theory methodology, examining four purposefully selected...
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Proximity and the Cluster Organization
PublikacjaIncluding the category of proximity in theoretical considerations and empirical analyzes in cluster organizations is an attempt to integrate existing approaches to understand and explain the specificity of inter-organizational cooperation developed in geographical proximity. The importance of geographical proximity to create a competitive advantage is emphasized in all theories on the establishment and development of industrial...
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Development of proximity in cluster organizations
PublikacjaSustainable development in cluster organizations (COs) is most fully manifested in the synergy effect. In turn, the synergy effect is achieved thanks to the development of proximity among cluster entities. The purpose of the paper is to test two conceptual models reflecting relations between selected dimensions of proximity in cluster organizations. The author reports the findings of a quantitative study conducted in four COs....
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The significance of proximity in cluster initiatives
PublikacjaPurpose – The main aim of this paper is to analyse relations between geographical and competence proximity and development of cooperation in cluster initiatives. Design/methodology/approach – The research was based on an original theoretical concept referring to the trajectory of development of cooperative relations in cluster initiatives. The research was carried out in mid-2017, in four purposefully selected clusterinitiatives....
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The Factors Affecting Group Identity of Cluster Structures
PublikacjaThe paper provides a new approach to cluster analysis, basing on a sociologically rooted concept of identity. The authors state that identity in cluster structures is formed by two main groups of factors – uncontrollable or slightly controllable factors (identity mix) and factors that can be fully controlled by a cluster initiative (corporate identity mix). It means that the cluster coordinator is able to consciously build the...
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The Cluster Organization. Analyzing the Development of Cooperative Relationships
PublikacjaCluster organizations are becoming more and more popular, both in developing and developed countries. Considering the development of cluster policy and the related dynamic growth of cluster initiatives in the world, the lack of sufficient knowledge on the development of cooperation in cluster organizations inhibits their development and, in many cases, causes their complete disintegration. The book provides new important elements...