Wyniki wyszukiwania dla: PROTEIN-DNA INTERACTIONS

• Generation and Characterization of a DNA-GCN4 Oligonucleotide-Peptide Conjugate: The Impact DNA/Protein Interactions on the Sensitization of DNA

  Publikacja

  • P. Wityk
  • R. Piątek
  • D. Kostrzewa-Nowak
  • R. Nowak

  - MOLECULES - Rok 2020

  Radiotherapy, the most common therapy for the treatment of solid tumors, exerts its effects by inducing DNA damage. To fully understand the extent and nature of this damage, DNA models that mimic the in vivo situation should be utilized. In a cellular context, genomic DNA constantly interacts with proteins and these interactions could influence both the primary radical processes (triggered by ionizing radiation) and secondary reactions,...

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• Interactions of antitumor triazoloacridinones with DNA

  Publikacja

  • M. Koba
  • J. Konopa

  - Acta Biochimica Polonica - Rok 2007

  W niniejszej pracy zbadano oddziaływanie sześciu wybranych pochodnych triazoloakrydonu z DNA. Analiza wiskozymetryczna pokazała, że związki te interkalują do DNA. Jednocześnie dalsze badania wykazały, że proces interkalacji nie jest istotny aktywności cytotoksycznej tej grupy związków. Badania z wykorzystaniem fibroblastów dowiodły, że jedna z pochodnych triazoloakrydonu, związek C-1305, po uprzedniej metabolicznej aktywacji indukuje...

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• Lipid-protein interactions in membranes: a molecular modelling study

  Publikacja

  • M. Pasenkiewicz-Gierula
  • M. Markiewicz
  • A. Gieldon
  • C. Czaplewski
  • J. Ciarkowski
  • C. Czaplewski

  - ACTA CRYSTALLOGRAPHICA SECTION A - Rok 2002

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• Role of Oligosaccharide Chain Polarity in Protein–Glycosaminoglycan Interactions

  Publikacja

  • K. Bojarski
  • S. Samsonov

  - Journal of Chemical Information and Modeling - Rok 2021

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• Thermodynamics aspects of interactions between acridine derivatives and DNA

  Publikacja

  • K. Jagiełło
  • A. Dopierała
  • J. Mazerski

  - Rok 2010

  DNA is a molecular target for many anticancer and antiviral drugs. Therefore, a clear understanding of the interaction of small molecules with DNA is important in the rational design of ligands that can bind to DNA with high affinity and selectivity. There are several methods to investigate interactions between drug and DNA. Some of them measure changing into DNA structures, such as lengthening and untwisting of helix of DNA. Other...

• Raman spectroscopic study of Ni2+-DNA interactions in aqueous systems

  Publikacja

  • J. Stangret
  • R. Savoie

  - PHYSICAL CHEMISTRY CHEMICAL PHYSICS - Rok 2002

  Metodą ramanowskich widm różnicowych określono sposób oddziaływania jonu Ni2+ z DNA(CT) w układach wodnych. Kation Ni(II) koordynuje w pozycjach N7 guaniny (G) i adeniny (A) w powtarzających się sekwencjach GG, AA i GA cząsteczki DNA. Jednocześnie Ni2+ oddziałuje zewnątrz sferowo poprzez cząsteczki wody z grupami fosforanowymi DNA.

• Taq DNA polymerase fused with DNA binding protein with increased resistance to inhibitors from clinical samples

  Publikacja

  • M. Skwarecka
  • B. Krawczyk
  • M. Olszewski

  - Rok 2015

  Nowadays PCR method is commonly used in molecular diagnostic. However, in many cases PCR is limited, by the presence of inhibitory substances in biological, soil or food samples Efficiency and fidelity of amplification is strongly connected with DNA polymerase and reaction conditions. To meet the requirements of modern diagnostic methods it is essential to seeking for new DNA polymerases with better properties useful in these field....

• How water mediates the long-range interactions between remote protein molecules

  Publikacja

  • A. Kuffel

  - PHYSICAL CHEMISTRY CHEMICAL PHYSICS - Rok 2017

  The high crowding of macromolecules in the cytoplasm affects the processes that occur inside a living cell. It can, for example, promote the forming of various loosely connected structures of proteins. It also means that bulk water is, essentially, not present there. The relatively thin layer of solvent that separates macromolecules may be able to participate in the long-range interactions between them and make them respond to...

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• Hot spot identification by ligand-protein surface interactions mapping – in silico study

  Publikacja

  • A. Stanczak
  • T. Magdziarz
  • A. Raczynska
  • A. Góra

  - New Biotechnology - Rok 2018

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• Fusion of Taq DNA polymerase with single-stranded DNA binding-like protein of Nanoarchaeum equitans—Expression and characterization

  Publikacja

  • M. Olszewski
  • M. Skwarecka
  • M. Bilek
  • B. Krawczyk

  - PLOS ONE - Rok 2017

  DNA polymerases are present in all organisms and are important enzymes that synthesise DNA molecules. They are used in various fields of science, predominantly as essential components for in vitro DNA syntheses, known as PCR. Modern diagnostics, molecular biology and genetic engineering need DNA polymerases which demonstrate improved performance. This study was aimed at obtaining a new NeqSSB-TaqS fusion DNA polymerase from the...

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