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• Ipertrofan Revisited—The Proposal of the Complete Stereochemistry of Mepartricin A and B

  Publikacja

  • P. Szczeblewski
  • W. Andrałojć
  • J. Polit
  • A. Żabka
  • K. Winnicki
  • T. Laskowski

  - MOLECULES - Rok 2021

  Being a methyl ester of partricin, the mepartricin complex is the active substance of a drug called Ipertrofan (Tricandil), which was proven to be useful in treatment of benign prostatic hyperplasia and chronic nonbacterial prostatitis/chronic pelvic pain syndrome. Nevertheless, no direct structural evidence on the stereochemistry of its components has been presented to date. In this contribution, we have conducted detailed, NMR-driven...

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• Quest for the Molecular Basis of Improved Selective Toxicity of All-Trans Isomers of Aromatic Heptaene Macrolide Antifungal Antibiotics

  Publikacja

  • J. Borzyszkowska-Bukowska
  • J. Górska
  • P. Szczeblewski
  • T. Laskowski
  • I. Gabriel
  • J. Jurasz
  • K. Kozłowska-Tylingo
  • P. Szweda
  • S. Milewski

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Rok 2021

  Three aromatic heptaene macrolide antifungal antibiotics, Candicidin D, Partricin A (Gedamycin) and Partricin B (Vacidin) were subjected to controlled cis-trans to all trans photochemical isomerization. The obtained all-trans isomers demonstrated substantially improved in vitro selective toxicity in the Candida albicans cells: human erythrocytes model. This effect was mainly due to the diminished hemotoxicity. The molecular modeling...

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