Rok 2019

• Are the short cationic lipopeptides bacterial membrane disruptors? Structure-Activity Relationship and molecular dynamic evaluation

  Publikacja

  • K. Greber
  • J. Zielińska
  • Ł. Nierzwicki
  • K. Ciura
  • P. Kawczak
  • J. Nowakowska
  • T. Bączek
  • W. Sawicki

  - BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES - Rok 2019

  Short cationic lipopeptides are amphiphilic molecules that exhibit antimicrobial activity mainly against Grampositives. These compounds bind to bacterial membranes and disrupt their integrity. Here we examine the structure-activity relation (SAR) of lysine-based lipopeptides, with a prospect to rationally design more active compounds. The presented study aims to explain how antimicrobial activity of lipopeptides is affected by...

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Rok 2016

• Analytical procedures for quality control of pharmaceuticals in terms of residual solvents content: Challenges and recent developments

  Publikacja

  • M. Tankiewicz
  • J. Namieśnik
  • W. Sawicki

  - TRAC-TRENDS IN ANALYTICAL CHEMISTRY - Rok 2016

  Residual solvents play an important role in the synthesis of drugs and in product formulations. In addition, they pose a serious problem, that is toxicity, as many of them exhibit toxic or environmentally hazardous properties. Therefore, constant monitoring of quality control is needed. In this study, we present an overview of regulatory and general methods described by various pharmacopoeias. Then, the most commonly used methodologies...

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