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Abstract
Hypoglycaemic pharmaceuticals are recently more and more frequently detected in the environment. In our previous study, we have shown that even though many of them undergo significant primary degradation some are transformed to stable products or undergo such transformation that a large part of the structure is still preserved. One of the main routes of elimination from wastewaters or surface waters is biodegradation and a lack thereof leads to accumulation in the environment. Within this work we tested the ultimate biodegradability of six oral antidiabetics: metformin and its main metabolite guanylurea, acarbose, glibenclamide, gliclazide, glimepiride and repaglinide. We also compared the experimental results obtained in this and accompanying work with models designed to predict biodegradability and showed that these models are only moderately successful. Additionally, we examined these compounds in acute Daphnia magna test to check if they might pose an ecotoxicological threat. Combining the results of biodegradability and toxicity tests allows a preliminary assessment of their potential environmental impact.
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Authors (6)
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Stefan Stolte
- University of Bremen Centre for Environmental Research and Technology
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Anna Białk-Bielińska
- University of Gdańsk Faculty of Chemistry
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Jolanta Kumirska
- University of Gdańsk Faculty of Chemistry
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
JOURNAL OF HAZARDOUS MATERIALS
no. 333,
pages 154 - 161,
ISSN: 0304-3894 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Markiewicz M., Jungnickel C., Stolte S., Białk-Bielińska A., Kumirska J., Mrozik W.: Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs// JOURNAL OF HAZARDOUS MATERIALS. -Vol. 333, (2017), s.154-161
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.jhazmat.2017.03.030
- Verified by:
- Gdańsk University of Technology
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