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Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs

Abstrakt

Hypoglycaemic pharmaceuticals are recently more and more frequently detected in the environment. In our previous study, we have shown that even though many of them undergo significant primary degradation some are transformed to stable products or undergo such transformation that a large part of the structure is still preserved. One of the main routes of elimination from wastewaters or surface waters is biodegradation and a lack thereof leads to accumulation in the environment. Within this work we tested the ultimate biodegradability of six oral antidiabetics: metformin and its main metabolite guanylurea, acarbose, glibenclamide, gliclazide, glimepiride and repaglinide. We also compared the experimental results obtained in this and accompanying work with models designed to predict biodegradability and showed that these models are only moderately successful. Additionally, we examined these compounds in acute Daphnia magna test to check if they might pose an ecotoxicological threat. Combining the results of biodegradability and toxicity tests allows a preliminary assessment of their potential environmental impact.

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Creative Commons: CC-BY-NC-ND otwiera się w nowej karcie

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
JOURNAL OF HAZARDOUS MATERIALS nr 333, strony 154 - 161,
ISSN: 0304-3894
Język:
angielski
Rok wydania:
2017
Opis bibliograficzny:
Markiewicz M., Jungnickel C., Stolte S., Białk-Bielińska A., Kumirska J., Mrozik W.: Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs// JOURNAL OF HAZARDOUS MATERIALS. -Vol. 333, (2017), s.154-161
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.jhazmat.2017.03.030
Bibliografia: test
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Weryfikacja:
Politechnika Gdańska

wyświetlono 105 razy

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