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Search results for: PROACTIVE EMPLOYEE DEVELOPMENT
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Determination of benzodiazepines and Z-hypnotic drugs in whole blood samples by GC–MS/MS: Method development, validation and application
PublicationBenzodiazepines (BZDs) and Z-drugs are widely used as anxiolytics, sedative hypnotics, anticonvulsants and muscle relaxants. “Designer benzodiazepines” (DBZDs) are a new psychoactive substance class consisting of benzodiazepine derivatives that are not allowed for medical use and are known for being used recreationally. From a toxicologist standpoint, the huge number of such substances implicate a necessity for developing fast...
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Dependent self-employed individuals: are they different from paid employees?
PublicationThis study focuses on dependent self-employment, which covers a situation where a person works for the same employer as a typical worker while on a self-employment contractual basis, i.e., without a traditional employment contract and without certain rights granted to "regular" employees. The research exploits the individual-level dataset of 35 European countries extracted from the 2017 edition of the European Labour Force Survey...
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Development of headspace-gas chromatography-flame ionization detection procedure to determine volatile fatty acids in zoo organic waste leachate
PublicationNadrzędnym celem pracy było opracowanie metodyki oznaczania lotnych kwasów tłuszczowych z fazy nadpowierzchniowej opartej na chromatografii gazowej z detektorem płomieniowo-jonizacyjnym oraz sprawdzenie jej przydatności w analizie próbek odcieku ze składowiska odpadów ogrodu zoologicznego. Na podstawie przeprowadzonych badań określono warunki, w jakich przebiegać powinna izolacja lotnych kwasów tłuszczowych, a także określono najlepsze...
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Molecular docking studies towards development of novel Gly-Phe analogs for potential inhibition of Cathepsin C (dipeptidyl peptidase I).
PublicationCathepsin C is a cysteine protease required for activation of various pro-inflammatory serine proteases and, essentially, is of interest as a therapeutic target. Cathepsin C coordinate system was employed as a model to study the interaction of some already available inhibitors of Cathepsin C. Compounds containing Gly-Phe fragment with functional groups at its ends were designed by knowledge based approach. Using AutoDock and...
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Development of different methods for drugs and psychoactive substances extraction from hair samples and their identification based on HPLC-ESI-QTOF analysis
PublicationOver the past decade, the use of non-controlled designer drugs and drug of abuse has rapidly increased. Hair, as a human matrix, enables detection of drugs incorporated into its structure. Studies of presence and identification of drug metabolites in human hair samples has been performed using liquid chromatography electrospray ionization quadrupole time of flight mass spectrometry (HPLC-ESI-QTOF-MS) with steady alternation of...
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Development of Nanocomposite based Antimicrobial Cotton Fabrics Impregnated by Nano SiO2 Loaded AgNPs Derived from Eragrostis Teff straw
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Development of Physics-Based Energy Functions that Predict Medium-Resolution Structures for Proteins of the α, β, and α/β Structural Classes
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Muscle Cell Morphogenesis, Structure, Development and Differentiation Processes Are Significantly Regulated during Human Ovarian Granulosa Cells In Vitro Cultivation
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Built Heritage, Sustainable Development, and Natural Hazards: Flood Protection and UNESCO World Heritage Site Protection Strategies in Krakow, Poland
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Identification of Powdery Mildew Blumeria graminis f. sp. tritici Resistance Genes in Selected Wheat Varieties and Development of Multiplex PCR
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The development of an artificial neural network correlation for prediction of rotating magnetic field effects on the process of production of disperse systems Fe3O4–Liquid
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Element analysis of bee-collected pollen and bee bread by atomic and mass spectrometry – Methodological development in addition to environmental and nutritional aspects
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Repeated bouts of exhaustive exercise increase circulating cell free nuclear and mitochondrial DNA without development of tolerance in healthy men
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Rural Landscapes of Roman (northern) Liburnia: Diachronic Development of Organisation and the Economy in Extra-Urban Territories in the Light of Recent Archaeological Research
PublicationThe archaeology of Roman rural landscapes in the province of Dalmatia, and especially northern Liburnia, has until recently focused on single-site or single-monument analyses, allowing for only geographically patchy and chronologically limited conclusions. Considering the results of recent research in the wider Kvarner and sub-Velebit area, the paper discusses issues of Roman extra-urban territorial organization, the formation...
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South Baltic Oil Spill Response Project (SBOIL)—Development and Implementation of Models of Drift and Fall Trajectories of Biogenic Oil Binders
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Multi-Objective Genetic Algorithm (MOGA) As a Feature Selecting Strategy in the Development of Ionic Liquids’ Quantitative Toxicity–Toxicity Relationship Models
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Radiation dose distributions in three dimensions from tomographic optical density scanning of polymer gels: I. Development of an optical scanner
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Can antimicrobial blue light contribute to resistance development? Genome-wide analysis revealed aBL-protective genes in Escherichia coli
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Amphotericin B derivatives: novel strategy for the development of non-toxic, broad spectrum, fungicidal and overcoming multidrug resistance antifungal agents.
PublicationZaprezentowano porównawczą charakterystykę działania amfoterycyny B (AmB) oraz jej pochodnych o różnym stopniu selektywnej toksyczności na szczepy grzybów reperezentujących różne mechanizmy oporności. Były to mutanty C. albicans posiadające defekt w szlaku biosyntezy ergosterolu oraz wielolekooporne szczepy S. cerevisiae wyposażone w pompy eksportujące typu ABC i MFS. Badania obejmowały: 1)porównanie aktywności przeciwgrzybowej...
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Determinants and effects of Poland’s road accidents in the context of the 2030 agenda for sustainable development – poviat level analysis for the years 2010-2019
PublicationThe objective of the research was to assess how selected factors influence road safety in Poland’s poviats. To that end, an analysis was conducted of road accident determinants and effects in the poviats in the years 2010-2019. The time horizon fits in with Goal 3.6. of Agenda 2030, which is to halve the number of global deaths and injuries from road traffic accidents by 2020. The article pres-ents the analysis results for the...
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Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19
PublicationIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus SARS-CoV-2). Within the set of new Mpro inhibitors, 6e demonstrated the highest activity in the enzymatic assay with an IC50 value of 8.52 ± 0.44 mM. The IC50 value for Nirmatrelvir (PF-07321332,...
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Enhancing women’s engagement in economic activities through information and communication technology deployment: evidence from Central–Eastern European countries
PublicationThis study takes a macro perspective to examine the associations between the economic deployment of information and communication technology (ICT), women’s labor market participation, and economic growth in Central–Eastern European countries between 1990 and 2017. We use data extracted from World Bank Development Indicators, World Development Reports, and the World Telecommunication/ICT Indicators Database. Our methodological framework...
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Factors hindering and boosting SDG7 implementation in EU countries
PublicationOne of the sustainable development goals (SDG7) is to ensure access to clean and affordable energy, which is related to most other SDGs and plays a crucial role in eco - nomic development and human well-being. The aim of the article is to identify factors that enhance and delay one of the most crucial goals of sustainable development, SDG7. The study’s originality lies in the spatiotemporal approach to analysing the impact of...
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ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) affects development, photosynthesis, and hormonal homeostasis in hybrid aspen ( Populus tremula L. × P. tremuloides )
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High-Speed Videoendoscopy Enhances the Objective Assessment of Glottic Organic Lesions: A Case-Control Study with Multivariable Data-Mining Model Development
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Evaluation of floor-wise pollution status and deposition behavior of potentially toxic elements and nanoparticles in air conditioner dust during urbanistic development
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Systolic blood pressure control prevents cognitive decline and slows development of white matter lesions in the brain: the SPRINT MIND study outcomes
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Harman and norharman, metabolites of entomopathogenic fungus Conidiobolus coronatus (Entomopthorales), disorganize development of Galleria mellonella (Lepidoptera) and affect serotonin-regulating enzymes
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Modeling the economic dependence between town development policy and increasing energy effectiveness with neural networks. Case study: The town of Zielona Góra
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Mutual Expression of ALDH1A1, LOX, and Collagens in Ovarian Cancer Cell Lines as Combined CSCs- and ECM-Related Models of Drug Resistance Development
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New Gene Markers of Angiogenesis and Blood Vessels Development in Porcine Ovarian Granulosa Cells during Short-Term Primary Culture In Vitro
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Epithelium morphogenesis and oviduct development are regulated by significant increase of expression of genes after long-term in vitro primary culture – a microarray assays
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‘Heart development and morphogenesis’ is a novel pathway for human ovarian granulosa cell differentiation during long‑term in�vitro cultivation‑a microarray approach
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Reconstructing human impact on peatland development during the past 200 years in CE Europe through biotic proxies and X-ray tomography
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Development of direct-current, atmospheric-pressure, glow discharges generated in contact with flowing electrolyte solutions for elemental analysis by optical emission spectrometry
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Development and Validation of a UPLC-MS/MS Method for Therapeutic Drug Monitoring, Pharmacokinetic and Stability Studies of First-Line Antituberculosis Drugs in Urine
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The Effects of Temperature Curing on the Strength Development, Transport Properties, and Freeze-Thaw Resistance of Blast Furnace Slag Cement Mortars Modified with Nanosilica
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Measuring Consumers' Engagement With Brand-Related Social-Media Content. Development and Validation of a Scale that Identifies Levels of Social-Media Engagement with Brands
PublicationThe purpose of the current study was to develop a scale to measure the consumer's engagement with brand-related social-media content, based on three dimensions established in the framework of an earlier theoretical construct, “Consumer's Online Brand-Related Activities” (Muntinga, Moorman, and Smit, 2011). Qualitative techniques were used to generate an initial pool of items that captured different levels of consumer engagement...
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Hybridization of valuation procedures as a medicine supporting the real estate market and sustainable land use development during the covid-19 pandemic and afterwards
PublicationCurrently we are facing the pandemic situation that occur all over the world. Regardless the country or even the region, the negative consequences that are expected could be very big and the level of crisis is not predictable. This situation is the challenge for the real estate market as well. Due to this fact, the authors believe that there is the time when deep transformation of approaches, procedures and awareness related to...
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Development of biocompatible iron oxide-silicon oxide core-shell nanoparticles as subcellular delivery platform for glucosamine-6-phosphate synthase inhibitors
PublicationIn order to develop the preparation of iron oxide-silica coreshell nanoparticles (CSNPs), thesis deeply explores the cetyltrimethylammonium (CTA+) directed silica coating methods of the oleic-acid capped iron oxide nanoparticles (OA-IONPs) initialized under near-neutral pH conditions. It is demonstrated that the initial alkaline hydrolysis of ethyl acetate in the presence of CTA+ and OA-IONPs induces an unusual ligand exchange...
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Development of a vortex-assisted switchable-hydrophilicity solvent-based liquid phase microextraction for fast and reliable extraction of Zn (II), Fe (II), Pb (II), and Cd (II) from various baby food products
PublicationThis manuscript describes the development of a novel liquid phase microextraction (LPME) method for the extraction and determination of Zn (II), Fe (II), Pb (II), and Cd (II) in various infant/baby food and supplements products. The method is based on vortex-assisted extraction combined with a switchable-hydrophilicity solvent (SHS) sample preparation. The SHS, which undergoes reversible phase changes triggered by pH change, enables...
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Method development and validation for optimized separation of quercetin derivatives in selected Potentilla species using high-performance thin-layer chromatography photodensitometry method
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The Role of GLP-1, GIP, MCP-1 and IGFBP-7 Biomarkers in the Development of Metabolic Disorders: A Review and Predictive Analysis in the Context of Diabetes and Obesity
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GIS Technology, 3D Models and Mathematical Models as a Tool for Assessing Development Capabilities of Flood Risk Land to Make Arrangements of Municipal Planning Documents
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Viral infection-oxidative stress/DNA damage-aberrant DNA methylation: separate or interrelated events responsible for genetic instability and childhood ALL development?
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Trends in Automotive Emission Legislation: Impact on LD Engine Development, Fuels, Lubricants and Test Methods: a Global View, with a Focus on WLTP and RDE Regulations
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Thermal Energy Development in Magnetohydrodynamic Flow Utilizing Titanium Dioxide, Copper Oxide and Aluminum Oxide Nanoparticles: Thermal Dispersion and Heat Generating Formularization
PublicationThe main aim of this article heat transfer in thermal engineering deals with the production, use, transformation, and transfer of thermal energy. Engineering and industrial fields including food packaging, the production of food additives, electronic cooling, microturbines, etc. heavily rely on heat transmission. Due to its intriguing potential in industries like the production of polymers, paper, crystal glass, etc., scientists...
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Development of a new green analytical methodology for the determination of phthalates in single-use babies diapers using ultrasound-assisted extraction and polypropylene porous membrane
PublicationA green extraction strategy was developed and utilized for the extraction and determination of phthalates. The extraction is based on ultrasound-assisted extraction and a polypropylene porous membrane. The Box-Behnken model was performed to optimize the extraction condition. The optimal extraction conditions are 5.5 mL of ethyl acetate, 10 min of extraction time and 55 C for extraction temperature. The developed green extraction...
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How to achieve sustainability?-Employee's point of view on company's culture and CSR practice
PublicationThe people are the company. This study aims to examine the structure of relationships between company culture, performance, corporate social responsibility (CSR), and reputation, as seen from the employee's perspective, to determine which company culture factors most influence CSR practice and, as a result, sustain a company's development and improve its performance. To accomplish this goal, we conducted a survey among employees...
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Smart Document-Centric Processing of Human Oriented Information Flows
PublicationUsually people prefer to focus on creative rather than repetitive and schematic work patterns. Still, they must spend a lot of time complying with the procedures, selecting the information they receive and repeatedly restoring the previous state of work. This paper proposes the Mobile INteractive Document architecture (MIND) - a document-centric uniform interface to provide both effective communication of content and coordination...