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Search results for: john henry newman
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Microbeam radiation therapy: Tissue dose penetration and BANG-gel dosimetry of thick-beams’ array interlacing
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Pomiar sił w wantach mostu podwieszonego
PublicationW artykule przedstawiono metodę oraz wyniki badań sił w wantach Mostu III Tysiąclecia im. Jana Pawła II w Gdańsku. Do identyfikacji sił wykorzystano trzy metody: wibracyjną; z wykorzystaniem siłownika jednosplotowego (lift-off) oraz pomiaru strzałki ugięcia. Przedstawione wyniki badań dowodzą, że wszystkie metody mogą być z powodzeniem wykorzystywane do identyfikacji rzeczywistej siły w wancie. Każda z metod ma jednak ograniczenia...
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Retained features of embryonic metabolism in the adult MRL mouse
PublicationThe MRL mouse is an inbred laboratory strain that was derived by selective breeding in 1960 from the rapidly growing LG/J (Large) strain. MRL mice grow to nearly twice the size of other commonly used mouse strains, display uncommonly robust healing and regeneration properties, and express later onset autoimmune traits similar to Systemic Lupus Erythematosis. The regeneration trait (heal) in the MRL mouse maps to 14-20 quantitative...
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Ovarian tissue cryopreservation by stepped vitrification and monitored by X-ray computed tomography
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Allergic inflammation in lungs and nasal epithelium of rat model is regulated by tissue-specific miRNA expression
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In search of a new relationship between nature and society
PublicationWe live in an era of breakthrough- not only in the literal sense of the word, but the breakthrough of the century or the millennium. New discoveries and the crisis present in the economy, society, religion and ecology forces a review of all universally accepted theories. Nature, ecology and environment are the key words used in every area of human activity. It has led to the development of a new scientific field- the philosophy...
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Hybrid SONIC: joint feedforward–feedback narrowband interference canceler
PublicationSONIC (self-optimizing narrowband interference canceler) is an acronym of a recently proposed active noise control algorithm with interesting adaptivity and robustness properties. SONIC is a purely feedback controller, capable of rejecting nonstationary sinusoidal disturbances (with time-varying amplitude and/or frequency) in the presence of plant (secondary path) uncertainty. We show that although SONIC can work reliably without...
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Association between the NAT1 1095C > A polymorphism and homocysteine concentration
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An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women
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A CRISPR/Cas9-Based Mutagenesis Protocol for Brachypodium distachyon and Its Allopolyploid Relative, Brachypodium hybridum
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The Reduced Folate Carrier (SLC19A1) c.80G>A Polymorphism is Associated with Red Cell Folate Concentrations Among Women
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Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus aureus Bloodstream Infection
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Proteomic profile of melanoma cell‐derived small extracellular vesicles in patients’ plasma: a potential correlate of melanoma progression
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Experiences of people with dementia and informal caregivers with post‐diagnostic support: Data from the international COGNISANCE study
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Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
PublicationThe structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA...
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Retinoic acid‐induced autoantigen‐specific type 1 regulatory T cells suppress autoimmunity
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Generation of large finite-element matrices on multiple graphics processors
PublicationThis paper presents techniques for generating very large finite-element matrices on a multicore workstation equipped with several graphics processing units (GPUs). To overcome the low memory size limitation of the GPUs, and at the same time to accelerate the generation process, we propose to generate the large sparse linear systems arising in finite-element analysis in an iterative manner on several GPUs and to use the graphics...
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Organic carbon fluxes of a glacier surface: a case study of Foxfonna, a small Arctic glacier
PublicationArctic glaciers are rapidly responding to global warming by releasing organic carbon (OC) to downstream ecosystems. The glacier surface is arguably the most biologically active and biodiverse glacial habitat and therefore the site of important OC transformation and storage, although rates and magnitudes are poorly constrained. In this paper, we present measurements of OC fluxes associated with atmospheric deposition, ice melt,...
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Advanced Potential Energy Surfaces for Molecular Simulation
PublicationAdvanced potential energy surfaces are defined as theoretical models that explicitly include many-body effects that transcend the standard fixed-charge, pairwise-additive paradigm typically used in molecular simulation. However, several factors relating to their software implementation have precluded their widespread use in condensed-phase simulations: the computational cost of the theoretical models, a paucity of approximate models...
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The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses ood intake and food-reinforced behavior but does not induce signs of nausea in rats
PublicationPrzeprowadzone badania biochemiczne wykazują, że związek AM4113 wiąże się z receptorem kanabinoidowym CB1, ale nie wykazuje właściwości odwrotnego agonisty (między innymi nie wpływa na powstawanie cyklicznego AMP). W testach na swobodne przemieszczanie się szczurów i znieczulenie związek AM4113 osłabia wpływ agonisty AM411 na receptor CB1. AM4113 wpływa na zachowanie szczurów związane z karmieniem oraz powoduje spadek łaknienia...
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Increased expression of ORMDL3 in allergic asthma: a case control and in vitro study
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Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a dimericcRGD Peptide for Targeted Imaging of αVβ3 Integrin Activity
PublicationCyclic peptides containing the Arg-Gly-Asp (RGD) sequence have been shown to specifically bind the angiogenesis biomarker α V β3 integrin. We report the synthesis, chemical characterization, and biological evaluation of two novel dimeric cyclic RGD-based molecular probes for the targeted imaging of α V β3 activity (a radiolabeled version, 64Cu-NOTA-PEG4-cRGD2, for PET imaging, and a fluorescent version, FITC-PEG4-cRGD2, for in...
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What Do We Know about Social and Non-Social Factors Influencing the Pathway from Cognitive Health to Dementia? A Systematic Review of Reviews
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[18F]Amylovis as a Potential PET Probe for β-Amyloid Plaque: Synthesis, In Silico, In vitro and In vivo Evaluations
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Prospective subgroup analyses of the randomized MCL-002 (SPRINT) study: lenalidomide versus investigator's choice in relapsed or refractory mantle cell lymphoma
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The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer
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Recognition of social health: A conceptual framework in the context of dementia research
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International Expert Consensus Statement
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[P4–544]: MEETINGDEM REPORTING ON THE IMPLEMENTATION, EFFECTIVENESS AND COST‐EFFECTIVENESS OF THE DUTCH MEETING CENTRES SUPPORTS PROGRAMME FOR PEOPLE LIVING WITH DEMENTIA AND FAMILY CARERS IN THREE EUROPEAN COUNTRIES
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Therapeutic targeting of cathepsin C: from pathophysiology to treatment
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Ecological traits predict population trends of urban birds in Europe
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Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases
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Inhibitor kinazy Brutona u chorych z nawrotowym lub opornym na leczenie chłoniakiem z komórek płaszcza – wyniki międzynarodowego, wieloośrodkowego, badania II fazy z ibrutynibem (PCI-32765) – EHA Encore
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Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study
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Modeling SARS‐CoV‐2 proteins in the CASP‐commons experiment
PublicationCritical Assessment of Structure Prediction (CASP) is an organization aimed at advancing the state of the art in computing protein structure from sequence. In the spring of 2020, CASP launched a community project to compute the structures of the most structurally challenging proteins coded for in the SARS-CoV-2 genome. Forty-seven research groups submitted over 3000 three-dimensional models and 700 sets of accuracy estimates on...
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Farmland practices are driving bird population decline across Europe
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Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 study
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Ibrutinib as Treatment for Patients With Relapsed/Refractory Follicular Lymphoma: Results From the Open-Label, Multicenter, Phase II DAWN Study
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Lenalidomide versus investigator's choice in relapsed or refractory mantle cell lymphoma (MCL-002; SPRINT): a phase 2, randomised, multicentre trial
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Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial
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Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin’s Lymphoma
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Expertise: No Longer a Sine Qua Non for Guideline Authors?
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Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma
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Impacts of salvage logging on biodiversity: A meta-analysis
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Reply
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Expertise
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Direct brain stimulation modulates encoding states and memory performance in humans
PublicationPeople often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting,...
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Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age
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Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis
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Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes—an international multicentre retrospective study
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