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Search results for: hormone-dependent cancer
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Aberration of the enzymatic activity of Fhit tumor suppressor protein enhances cancer cell death upon photodynamic therapy similarly to that driven by wild-type Fhit
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Adipokine and cytokine levels in patients with adrenocortical cancer, subclinical Cushing's syndrome and healthy controls
PublicationIntroduction In recent years researchers have focused at hormonal activity in Cushing’s syndrome (CS) in connection with metabolic disorders and the role of adipokines and cytokines secreted by the adipose tissue. The aim of the study was to investigate levels of adipokines and cytokines in patients with: subclinical CS (SCS) – in relation to hormonal parameters of hypercortisolemia, and, adrenocortical cancer (ACC). Materials...
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Dietary intervention with beetroot juice during doxorubicin cancer chemotherapy in vivo reduces markers of oxidative stress
PublicationCancer chemotherapy with doxorubicin, despite high antitumor activity and broad spectrum of this drug, is on decline due to toxic side effects. The clinical efficacy of anthracyclines have continuously prompted the search for new adjuvants to alleviate undesirable side toxicity incurred by this group of cytostatics. The recent approaches involve the application of synthetic or purified natural antioxidants in combination with doxorubicin...
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Autoimmunity and Cancer—Two Sides of the Same Coin
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Arsenic causing gallbladder cancer disease in Bihar
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Catalytic topoisomerase II inhibitors in cancer therapy.
PublicationDNA topoizomeraza II jest jednym z głównych celów molekularnych dla leków stosowanych w terapii przeciwnowotworowej. Wszystkie inhibitory tego enzymu są zdolne do zakłócania w jeden z etapów cyklu katalitycznego topoizomerazy II. Związki, które stabilizują kowalencyjny kompleks DNa i topoizomerazy II (znany jako kompleks rozszczepialny) są nazywane truciznami topoizomerazy, inne związki, które hamują aktywność enzymu na innych...
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Inhibition of cancer antioxidant defense by natural compounds
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Patients’ Awareness Of The Prevention And Treatment Of Colorectal Cancer*
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Non‐Proteasomal Urine Activity in Bladder Cancer
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Elastolytic activity is associated with inflammation in bladder cancer
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Viral Infections and Cancer During Alcohol Use
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EZH2 and SMYD3 expression in papillary thyroid cancer
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The overexpression of CPR and P450 3A4 in pancreatic cancer cells changes the metabolic profile and increases the cytotoxicity and pro-apoptotic activity of acridine antitumor agent, C-1748
PublicationDrug resistance is one of the major cause of pancreatic cancer treatment failure. Thus, it is still imperative to develop new active compounds and novel approach to improve drug efficacy. Here we present 9-amino-1-nitroacridine antitumor agent, C-1748, developed in our laboratory, as a candidate for pancreatic cancer treatment. We examined (i) the cellular response of pancreatic cancer cell lines: Panc-1, MiaPaCa-2, BxPC-3 and...
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Method-Dependent Epidemiological Cutoff Values for Detection of Triazole Resistance in Candida and Aspergillus Species for the Sensititre YeastOne Colorimetric Broth and Etest Agar Diffusion Methods
PublicationAlthough the Sensititre Yeast-One (SYO) and Etest methods are widely utilized, interpretive criteria are not available for triazole susceptibility testing of Candida or Aspergillus species. We collected fluconazole, itraconazole, posaconazole, and voriconazole SYO and Etest MICs from 39 laboratories representing all continents for (method/agent-dependent) 11,171 Candida albicans, 215 C. dubliniensis, 4,418 C. glabrata species complex,...
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DNA-damaging imidazoacridinone C-1311 induces autophagy followed by irreversible growth arrest and senescence in human lung cancer cells
PublicationImidazoacridinone 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor inhibitor of topoisomerase II and FMS-like tyrosine kinase 3 receptor. In this study, we describe the unique sequence of cellular responses to C-1311 in human non-small cell lung cancer (NSCLC) cell lines, A549 and H460. In A549 cells, C-1311 (IC80 = 0.08 µM) induced G1 and G2/M arrests, whereas H460 cells (IC80 = 0.051 µM) accumulated...
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c-Myc Protein Level Affected by Unsymmetrical Bisacridines Influences Apoptosis and Senescence Induced in HCT116 Colorectal and H460 Lung Cancer Cells
PublicationUnsymmetrical bisacridines (UAs) are highly active antitumor compounds. They contain in their structure the drugs previously synthesized in our Department: C-1311 and C-1748. UAs exhibit different properties than their monomer components. They do not intercalate to dsDNA but stabilize the G-quadruplex structures, particularly those of the MYC and KRAS genes. Since MYC and KRAS are often mutated and constitutively expressed in cancer...
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Validation of EORTC, CUETO, and EAU risk stratification in prediction of recurrence, progression, and death of patients with initially non–muscle‐invasive bladder cancer (NMIBC): A cohort analysis
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Outcomes of gynecologic cancer surgery during the COVID-19 pandemic: an international, multicenter, prospective CovidSurg-Gynecologic Oncology Cancer study
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Imidazoacridinone C-1311 induces both autophagy and senescence in human lung cancer A549 cells
PublicationNiedrobnokomórkowy rak płuc (ang. NSCLC, non-small cell lung cancer), stanowiący blisko 80-87% wszystkich przypadków, jest najczęściej występującą formą raka płuc. Skuteczność dotychczas stosowanych chemoterapeutyków w stosunku do tej formy raka jest bardzo ograniczona dlatego poszukuje się nowych związków o lepszych właściwościach leczniczych. Imidazoakrydon C-1311 wykazuje wysoką aktywność cytotoksyczną wobec komórek niedrobnokomórkowego...
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Measurement of temperature-dependent viscosity and thermal conductivity of alumina and titania thermal oil nanofluids
PublicationThe results of simultaneous measurements of dynamic viscosity, thermal conductivity, electrical conductivity and pH of two nanofluids, i.e. thermal oil/Al2O3 and thermal oil/TiO2 are presented. Thermal oil was selected as a base liquid because of possible application in ORC systems as an intermediate heating agent. Nanoparticles were tested at the concentration of 0.1%, 1% and 5% by weight within temperature range from 20°C to...
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Concentration-Dependent Fluorescence Properties of Rhodamine 6G in Titanium Dioxide and Silicon Dioxide Nanolayers
PublicationWytworzono cienkie warstwy zawierające rodaminę 6G w dwutlenku tytanu (R6G/TiO2) i w dwutlenku krzemu (R6G/SiO2) stosując metodę zol-żel. Badane były dwa rodzaje matryc, w których domieszkowano barwnik rodamina 6G (R6G) o różnych koncentracjach. Został stwierdzony istotny wpływ koncentracji barwnika na widma absorpcji i emisji oraz na czasowo rozdzielone widma fluorescencji. W szczególności stwierdzono znacznie mniejszą zdolność...
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MEASUREMENT OF TEMPERATURE-DEPENDENT VISCOSITY AND THERMAL CONDUCTIVITY OF ALUMINA AND TITANIA THERMAL OIL NANOFLUIDS
PublicationIn this study results of simultaneous measurements of dynamic viscosity, thermal conductivity, electrical conductivity and pH of two nanofluids, i.e. thermal oil/Al2O3 and thermal oil/TiO2 are presented. Thermal oil is selected as a base liquid because of possible application in ORC systems as an intermediate heating agent. Nanoparticles were tested at the concentration of 0.1%, 1% and 5% by weight within temperature range from...
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EDS1-Dependent Cell Death and the Antioxidant System in Arabidopsis Leaves is Deregulated by the Mammalian Bax
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Asymptotic numerical solver for the linear Klein–Gordon equation with space- and time-dependent mass
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Expression of INHβA and INHβB proteins in porcine oocytes cultured in vitro is dependent on the follicle size
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Dissipated energy minimization in a combustion engine Mount system by position dependent damping coefficients
PublicationPraca opisuje rozważania na temat możliwości tłumienia drgań spalinowego silnika czterosuwowego. Do modelowania wykorzystano zasady dynamiki układów wielomasowych. Przedstawiono krótki opis wspomnianego sposobu modelowani. Zbudowano model numeryczny silnika. Model poddano analizie numerycznej. Podczas analizy dynamiki układu skoncentrowano się na elementach tłumiących drgania, obecnych w zawieszeniu silnika oraz na analizie wpływu...
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Temperature and potential-dependent structural changes in Pt cathode electrocatalyst viewed by in situ XAFS
PublicationW pracy przedstawiono wyniki badań widm absorpcji promieniowania rentgenowskiego nano-platyny używanej jako katalizator w katodach polimerowych ogniw paliwowych (PEM FC). Badania XAFS realizowane były w warunkach pracy ogniwa paliwowego. Wysokiej jakości widma, uzyskane za pomocą specjalnie przygotowanej do pomiarów XAFS in situ komórki FC, umożliwiły przeprowadzenie zaawansowanej analizy obrazującej zmiany w lokalnej strukturze...
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Size-dependent electronic properties of nanomaterials: How this novel class of nanodescriptors supposed to be calculated?
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Relationship between Telomere Length, TERT Genetic Variability and TERT, TP53, SP1, MYC Gene Co-Expression in the Clinicopathological Profile of Breast Cancer
PublicationThe molecular mechanisms of telomerase reverse transcriptase (TERT) upregulation in breast cancer (BC) are complex. We compared genetic variability within TERT and telomere length with the clinical data of patients with BC. Additionally, we assessed the expression of the TERT, MYC, TP53 and SP1 genes in BC patients and in BC organoids (3D cell cultures obtained from breast cancer tissues). We observed the same correlation in the...
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Circadian Gene Polymorphisms Associated with Breast Cancer Susceptibility
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Single nucleotide polymorphisms associated with papillary thyroid cancer
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Novel Inhibitor-Based Therapies for Thyroid Cancer—An Update
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High-grade serous ovarian cancer: the clone wars
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Probiotic Bacteria: A Promising Tool in Cancer Prevention and Therapy
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Recognition Dynamics of Cancer Mutations on the ERp57-Tapasin Interface
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Inhibitors of angiogenesis in cancer therapy – synthesis and biological activity
PublicationAngiogenesis is the process of formation of new capillaries from preexisting blood vessels. Angiogenesis is involved in normal physiological processes, and plays an important role in tumor invasion and development of metastases. Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis. VEGF is a mitogen for vascular endothelial cells and stimulates their proliferation. By inhibiting the biological activity of...
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Molecular diagnosis in type I epithelial ovarian cancer
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Coping strategies and sexual satisfaction in bladder cancer males
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The Effects of Single Nucleotide Polymorphisms in Cancer RNAi Therapies
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Neural network breast cancer relapse time prognosis
PublicationPrzedstawiono architekturę i wyniki testowania sztucznej sieci neuronowej w prognozowaniu czasu nawrotu choroby u kobiet chorych na raka piersi. Sieć neuronowa uczona była na danych zgromadzonych przez 20 lat. Dane opisują grupę 439 pacjentów za pomocą 40 parametrów. Spośród tych parametrów wybrano 6 najistotniejszych: liczbę przerzutowych węzłów chłonnych, wielkość guza, wiek, skalę według Blooma oraz stan receptorów estrogenowych...
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On the origin of surfaces-dependent growth of benzoic acid crystal inferred through the droplet evaporation method
PublicationCrystal growth behavior of benzoic acid crystals on different surfaces was examined. The performed experiments documented the existence of very strong influence introduced by polar surfaces as glass, gelatin, and polyvinyl alcohol (PVA) on the growth of benzoic acid crystals. These surfaces impose strong orientation effect resulting in a dramatic reduction of number of faces seen with x-ray powder diffractions (XPRD). However,...
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On the origin of surfaces-dependent growth of benzoic acid crystal inferred through the droplet evaporation method
PublicationCrystal growth behavior of benzoic acid crystals on different surfaces was examined. The performed experiments documented the existence of very strong influence introduced by polar surfaces as glass, gelatin, and polyvinyl alcohol (PVA) on the growth of benzoic acid crystals. These surfaces impose strong orientation effect resulting in a dramatic reduction of number of faces seen with x-ray powder diffractions (XPRD). However,...
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On the origin of surfaces-dependent growth of benzoic acid crystal inferred through the droplet evaporation method
PublicationCrystal growth behavior of benzoic acid crystals on different surfaces was examined. The performed experiments documented the existence of very strong influence introduced by polar surfaces as glass, gelatin, and polyvinyl alcohol (PVA) on the growth of benzoic acid crystals. These surfaces impose strong orientation effect resulting in a dramatic reduction of number of faces seen with x-ray powder diffractions (XPRD). However,...
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Light-dependent and light-independent protochlorophyllide oxidoreductases share similar sequence motifs -in silico studies
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Towards Temperature Dependent Coarse-grained Potential of Side-chain Interactions for Protein Folding Simulations
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Caratheodory solutions to quasi-linear hyperbolic systems of partial differential equations with state dependent delays
PublicationW pracy udowodniono twierdzenie o istnieniu i jednoznaczności rozwiązań oraz o ich ciągłej zależności od warunków początkowych dla układów równań różniczkowych cząstkowych z opóźnionym argumentem, zależnym od funkcji niewiadomej. Posłużono się metodą bicharakterystyk a istnienia dowiedziono stosując twierdzenie Banacha o punkcie stałym.
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Generalized solution of mixed problems for first order partial differential equations with state dependent delays
PublicationW pracy zostało udowodnione twierdzenie o istnieniu i jednoznaczności rozwiązań dla zagadnień początkowo-brzegowych z cząstkowym równaniem różniczkowo-funkcyjnym z opóźnionym argumentem zależnym od funkcji niewiadomej. Użyto metody bicharakterystyk. Jednoznaczność rozwiązań wykazano metodą porównawczą, istnienie - metodą ciągów przybliżeń.
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Evidence for electric field dependent dissociation of exciplexes in electron donor-acceptor organic solid films
PublicationBadano wpływ zewnętrznego pola elektrycznego na zanik luminescencji w układzie dendrymer aminowy m-MTDATA:fenantrolina BPT:poliwęglan PC oraz domieszkowanym organicznym kompleksem platyny. Zaobserwowano silne wygaszenie luminescencji na skutek dysocjacji ekscypleksów singletowych i trypletowych. Pole elektryczne obniżało zarówno amplitudę, jak i czas życia luminescencji.
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Voice Maps - portable, dedicated GIS for supporting street navigtion and self-dependent movement of the blind
PublicationThe concept and the prototype application of the system supporting the street navigation and independent, outdoor movement of the blind is presented. The system utilises the GIS database of geometric network of the pedestrian paths in the city and is capable of finding the route from the indicated source to destination. Subsequently, the system supports the movement of the blind along the found route. The information on the user's...
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ppGpp-Dependent Negative Control of DNA Replication of Shiga Toxin-Converting Bacteriophages in Escherichia coli
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