Search
Filters
total: 2475
-
Catalog
displaying 1000 best results Help
Search results for: MICROBIOTA OF HUMAN MILK
-
Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes
PublicationNew promising unsymmetrical bisacridine derivatives (UAs), have been developed. Three groupsincluding 36 compounds were synthesized by the condensation of 4-nitro or 4-methylacridinone, imi-dazoacridinone and triazoloacridinone derivatives with 1-nitroacridine compounds linked with anaminoalkyl chain. Cytotoxicity screening revealed the high potency of these compounds against severaltumor cell lines. Particularly, imidazoacridinone-1-nitroacridine...
-
PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells
PublicationTwo cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability.Approximately 5-10% of breast and ovarian cancers result from inherited alterations or mutations in these genes.Remarkably, BRCA1/BRCA2-deficient cells are hypersensitive to selective inhibition of poly(ADPribose) polymerase 1 (PARP-1),...
-
Human Vaccines & Immunotherapeutics
Journals -
Discriminating macromolecular interactions based on an impedimetric fingerprint supported by multivariate data analysis for rapid and label-free Escherichia coli recognition in human urine
PublicationThis manuscript presents a novel approach to address the challenges of electrode fouling and highly complex electrode nanoarchitecture, which are primary concerns for biosensors operating in real environments. The proposed approach utilizes multiparametric impedance discriminant analysis (MIDA) to obtain a fingerprint of the macromolecular interactions on flat glassy carbon surfaces, achieved through self-organized, drop-cast,...
-
Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?
PublicationIntestinal bacteria are equipped with an enzyme apparatus that is involved in the active biotrans-formation of xenobiotics, including drugs. Pharmacomicrobiomics, a new area of pharmacology, analyses interactions between bacteria and xenobiotics. However, there is another side to the coin. Pharmacotherapeutic agents can significantly modify the microbiota, which consequently affects their efficacy. In this review, we comprehensively...
-
An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples
Publication -
Haloperidol, but not olanzapine, may affect expression of PER1 and CRY1 genes in human glioblastoma cell line
Publication -
Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells
Publication -
Nonlinear dynamic analysis of the pure “buckling” mechanism during blow-out trauma of the human orbit
Publication -
Bulky DNA adducts in human sperm: relationship with fertility, semen quality, smoking, and environmental factors
Publication -
Prevalence of human pathogens of the clade Nakaseomyces in a culture collection—the first report on Candida bracarensis in Poland
Publication -
Human Health Risk Assessment on the Consumption of Apples Growing in Urbanized Areas: Case of Kharkiv, Ukraine
Publication -
Inhibition of HIV‐1 or bacterial activation of macrophages by products of HIV‐1‐resistant human cells
Publication -
Carboxymethylated starch and cellulose derivatives-based film as human skin equivalent for adhesive properties testing
Publication -
Environmental Phage-Based Cocktail and Antibiotic Combination Effects onAcinetobacter baumanniiBiofilm in a Human Urine Model
Publication -
Irreversible alterations in the hemoglobin structure affect oxygen binding in human packed red blood cells
Publication -
Temporal sequence of the human RBCs' vesiculation observed in nano-scale with application of AFM and complementary techniques
Publication -
Human sperm proteins identified by 2-dimensional electrophoresis and mass spectrometry and their relevance to a transcriptomic analysis
Publication -
Effects of flavonoids on expression of genes involved in cell cycle regulation and DNA replication in human fibroblasts
Publication -
Molecular dynamics simulation of human neurohypophyseal hormone receptors complexed with oxytocin—modeling of an activated state
Publication -
Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2′-deoxyguanosine
Publication -
Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study
Publication -
Human bone marrow as a tissue in post-mortem identification and determination of psychoactive Substances—Screening methodology
Publication -
Ochratoxin A, deoxynivalenol, T-2 and HT-2 toxins – occurrence in food and their effect on the human body
Publication -
Missing the sweet spot: one of the two N-glycans on human Gb3/CD77 synthase is expendable
Publication -
Experimental immunology First report of cylindrospermopsin effect on human peripheral blood lymphocytes proliferation in vitro
Publication -
<p>Nanomechanics and Histopathology as Diagnostic Tools to Characterize Freshly Removed Human Brain Tumors</p>
Publication -
Novel markers of human ovarian granulosa cell differentiation toward osteoblast lineage: A microarray approach
Publication -
Comparison of Fluoride Ion-Selective Electrode Based Potentiometric Methods of Fluoride Determination in Human Urine
Publication -
Biochemical properties of thyroid peroxidase (TPO) expressed in human breast and mammary-derived cell lines
Publication -
To donate or not to donate? Future healthcare professionals’ opinions on biobanking of human biological material for research purposes
Publication -
The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers
Publication -
Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors
Publication -
Using Flavonoid Substitution Status to Predict Anticancer Effects in Human Melanoma Cancers: An In Vitro Study
Publication -
Assessing the Interactions of Statins with Human Adenylate Kinase Isoenzyme 1: Fluorescence and Enzyme Kinetic Studies
Publication -
Human–environment interactions in medieval Poland: a perspective from the analysis of faunal stable isotope ratios
Publication -
The analysis of human leukocyte antigen‐G level in patients with endometrial cancer by Western blot technique
Publication -
Aqueous Extracts of Selected Potentilla Species Modulate Biological Activity of Human Normal Colon Cells
Publication -
The influence of extracts from Rubus caesius leaves on human colon carcinoma cells cultured in vitro
Publication -
Toxicovigilance 2.0 – modern approaches for the hazard identification and risk assessment of toxicants in human beings: A review
Publication -
Hierarchical influence diagrams for incorporating human and organizational factors in risk assessment of hazardous industrial systems
PublicationArtykuł dotyczy podstawowych zagadnień związanych z czynnikami organizacyjnymi i ludzkim w analizie ryzyka złożonych systemów przemysłowych. Analizuje się podobieństwa i różnice pomiędzy hierarchicznymi diagramami wpływu i hierarchicznym procesem analizy decyzyjnej i na tej podstawie proponuje się uogólnione podejście do rozważanej analizy decyzyjnej uwzględniające dane rozmyte.
-
ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators
PublicationFluoryzujące analogi fosfolipidów NBD-PE, NBD-PC i NBD-PS zostały wykorzystane w celu wykazania, że białko Cdr1p i jego inne homologi, Cdr2p i Cdr3p, należące do grupy białek zawierających tzw. kasetę wiążącą ATP (ABC), zachowują się jak ogólne przenośniki lipidów. Wyniki badań pokazują, że transportery typu ABC występujące w C. albicans są przenośnikami fosfolipidów i aktywność ta może być jedna z fizjologicznych funkcji białek.
-
The Effect of Marginal Zn2+ Excess Released from Titanium Coating on Differentiation of Human Osteoblastic Cells
PublicationComposite coatings based on chitosan and zinc nanoparticles (ZnNPs) were successfully produced on Ti13Zr13Nb substrates by cathodic electrophoretic deposition (EPD). The unfavorable phenomenon of water electrolysis-induced nonuniformity was reduced by applying a low voltage (20 V) and a short deposition time (1 min). Surface analysis (roughness and hydrophilicity) reveals the potential of these coatings for enhancing cell attachment...
-
Imidazoacridinone C-1311 induces both autophagy and senescence in human lung cancer A549 cells
PublicationNiedrobnokomórkowy rak płuc (ang. NSCLC, non-small cell lung cancer), stanowiący blisko 80-87% wszystkich przypadków, jest najczęściej występującą formą raka płuc. Skuteczność dotychczas stosowanych chemoterapeutyków w stosunku do tej formy raka jest bardzo ograniczona dlatego poszukuje się nowych związków o lepszych właściwościach leczniczych. Imidazoakrydon C-1311 wykazuje wysoką aktywność cytotoksyczną wobec komórek niedrobnokomórkowego...
-
Modulation of CYP1A1, CYP1A2 and CYP1B1 expression by cabbage juices and indoles in human breast cell lines
PublicationEpidemiological studies have shown that consumption of cab- bage and sauerkraut is connected with significant reduction of breast cancer incidences. Estrogens are considered a major breast cancer risk factor and their metabolism by P450 enzymes substan- tially contributes to carcinogenic activity. The aim of this study was to investigate the effect of cabbage and sauerkraut juices of differ- ent origin on the expression profile...
-
Podstawowe sposoby zwiększania wiarygodności wykonania przebiegów wymagających udziału człowieka w human workflow
PublicationOpisano pojęcie procesu biznesowego oraz przepływu pracy w kontekście automatyzacji mającej na celu optymalizację działań i podniesienie jakości usługi. Przedstawiono charakterystykę procesów pracy angażujących człowieka oraz wykorzystujących dedykowane wzorce przepływów tego typu. Zaproponowano zwiększenie stopnia automatyzacji wykonania procesu wraz z metodami zwiększania wiarygodności wykonania przebiegów pracy przez kontrolę...
-
Artificial intelligence support for disease detection in wireless capsule endoscopy images of human large bowel
PublicationIn the work the chosen algorithms of disease recognition in endoscopy images were described and compared for theirs efficiency. The algorithms were estimated with regard to utility for application in computer system's support for digestive system's diagnostics. Estimations were achieved in an advanced testing environment, which was built with use of the large collection of endoscopy movies received from Medical University in Gdańsk....
-
Unsupervised machine-learning classification of electrophysiologically active electrodes during human cognitive task performance
PublicationIdentification of active electrodes that record task-relevant neurophysiological activity is needed for clinical and industrial applications as well as for investigating brain functions. We developed an unsupervised, fully automated approach to classify active electrodes showing event-related intracranial EEG (iEEG) responses from 115 patients performing a free recall verbal memory task. Our approach employed new interpretable...
-
Derivatives of 1-nitroacridine induce apoptosis only in a limited number of human colon adenocarcinoma cells
PublicationPraca dotyczy indukcji apoptozy w komórkach ludzkich raków okrężnicy HT29 i HCT8 pod wpływem pochodnych 1-nitroakrydyny: C-857 i C-1748. Wykazano, że związki te w stężeniach biologicznie istotnych (EC90) indukują apoptozę tylko w części populacji komórek. Efekt ten uzależniony był od czasu inkubacji komórek ze związkiem, a nie zależał od stężenia związku.
-
Anna Brillowska-Dąbrowska dr hab. inż.
PeopleAnna Brillowska-Dąbrowska, born in 1971 in Gdańsk, Poland, graduated in 1996 in Biotechnology from the Faculty of Chemistry, Gdańsk University of Technology (GUT). In 2001 she got her PhD, in 2013 became a DSc (habilitation). She was employed in 2004 as a researcher in Statens Serum Institut in Denmark. Currently she is an Associate Professor (adiunkt) in the Department of Molecular Biotechnology and Microbiology and Vice-dean...