Search results for: pharmacokinetics and pharmacodynamics of drugs

• Environmental Fate of Two Psychiatric Drugs, Diazepam and Sertraline: Phototransformation and Investigation of their Photoproducts in Natural Waters

  Publication

  • A. Jakimska-Nagórska
  • M. Śliwka-Kaszyńska
  • P. Nagórski
  • A. Kot-Wasik
  • J. Namieśnik

  - Journal of Chromatography & Seperation Techniques - Year 2014

  Experimental studies were conducted to investigate the photodegradation of diazepam and sertraline, two of the most frequently used psychiatric drugs, induced by xenon lamp irradiation, which overlap the sunlight spectra, and natural sunlight. Degradation kinetics was established indicating the occurrence of autocatalytic reactions. The application of liquid chromatography coupled to quadrupole time-of-flight mass spectrometry...

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• Ti/TiO2 nanotubes sensitized PbS quantum dots as photoelectrodes applied for decomposition of anticancer drugs under simulated solar energy

  Publication

  • P. Mazierski
  • P. Wilczewska
  • W. Lisowski
  • T. Klimczuk
  • A. Białk-Bielińska
  • A. Zaleska-Medyska
  • E. Siedlecka
  • A. Pieczyńska

  - JOURNAL OF HAZARDOUS MATERIALS - Year 2022

  One of the challenges in research into photoelectrocatalytic (PEC) degradation of pollutants is finding the appropriate photoanode material, which has a significant impact on the process efficiency. Among all others, photoelectrodes based on an ordered TiO2 nanotube arrays are a promising material due to well-developed surface area and efficient charge separation. To increase the PEC activity of this material, the SILAR method was...

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• Pharmacokinetics of sufentanil during long-term infusion in critically ill pediatric patients

  Publication

  • A. Bartkowska-Śniatkowska
  • A. Bienert
  • P. Wiczling
  • J. Rosada-Kurasińska
  • M. Zielińska
  • J. Warzybok
  • A. Borsuk
  • D. Tibboel
  • R. Kaliszan
  • E. Grześkowiak

  - JOURNAL OF CLINICAL PHARMACOLOGY - Year 2016

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• Flip-Flop Phenomenon in Epidural Sufentanil Pharmacokinetics: A Population Study in Children and Infants

  Publication

  • A. Borsuk
  • B. Wołoszczuk-Gębicka
  • A. Bartkowska-Śniatkowska
  • J. Rosada-Kurasińska
  • A. Bienert
  • P. Wiczling

  - JOURNAL OF CLINICAL PHARMACOLOGY - Year 2017

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• Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?

  Publication

  • K. Kaźmierczak-Siedlecka
  • N. Bulman
  • P. Ulasiński
  • B. K. Sobocki
  • K. Polom
  • L. Marano
  • L. Kalinowski
  • K. Skonieczna-Żydecka

  - Gut Microbes - Year 2023

  Intestinal bacteria are equipped with an enzyme apparatus that is involved in the active biotrans-formation of xenobiotics, including drugs. Pharmacomicrobiomics, a new area of pharmacology, analyses interactions between bacteria and xenobiotics. However, there is another side to the coin. Pharmacotherapeutic agents can significantly modify the microbiota, which consequently affects their efficacy. In this review, we comprehensively...

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• Determination of benzodiazepines and Z-hypnotic drugs in whole blood samples by GC–MS/MS: Method development, validation and application

  Publication

  • L. Banaszkiewicz
  • M. K. Woźniak
  • M. Kaliszan
  • A. Kot-Wasik

  - MICROCHEMICAL JOURNAL - Year 2023

  Benzodiazepines (BZDs) and Z-drugs are widely used as anxiolytics, sedative hypnotics, anticonvulsants and muscle relaxants. “Designer benzodiazepines” (DBZDs) are a new psychoactive substance class consisting of benzodiazepine derivatives that are not allowed for medical use and are known for being used recreationally. From a toxicologist standpoint, the huge number of such substances implicate a necessity for developing fast...

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• EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

  Journals

  ISSN: 0378-7966 , eISSN: 2107-0180

• Machine learning applied to bi-heterocyclic drugs recognition

  Publication

  • M. Nowak
  • K. Nowak
  • M. Grzelczak
  • B. Szlachetko
  • L. Sterczewski
  • E. Plinski
  • P. Swiatek
  • M. Strzelecka
  • S. Plinska
  • W. Malinka

  - Year 2017

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• Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs

  Publication

  • M. Markiewicz
  • C. Jungnickel
  • S. Stolte
  • A. Białk-Bielińska
  • J. Kumirska
  • W. Mrozik

  - JOURNAL OF HAZARDOUS MATERIALS - Year 2017

  Hypoglycaemic pharmaceuticals are recently more and more frequently detected in the environment. In our previous study, we have shown that even though many of them undergo significant primary degradation some are transformed to stable products or undergo such transformation that a large part of the structure is still preserved. One of the main routes of elimination from wastewaters or surface waters is biodegradation and a lack...

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• Marine Drugs

  Journals

  ISSN: 1660-3397

• Pharmacokinetics and Antibody Responses to the CD3 Antibody Otelixizumab Used in the Treatment of Type 1 Diabetes

  Publication

  • G. Hale
  • P. Rebello
  • I. Al
  • E. Bolam
  • P. Wiczling
  • W. Jusko
  • E. Vandemeulebroucke
  • B. Keymeulen
  • C. Mathieu
  • A. Ziegler... and 3 others

  - JOURNAL OF CLINICAL PHARMACOLOGY - Year 2010

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• DRUGS IN R&D

  Journals

  ISSN: 1174-5886 , eISSN: 1179-6901

• Drugs and Alcohol Today

  Journals

  ISSN: 1745-9265 , eISSN: 2042-8359

• Clinical Cancer Drugs

  Journals

  ISSN: 2212-697X

• Drugs and Therapy Perspectives

  Journals

  ISSN: 1172-0360

• INVESTIGATIONAL NEW DRUGS

  Journals

  ISSN: 0167-6997 , eISSN: 1573-0646

• Journal of Psychoactive Drugs

  Journals

  ISSN: 0279-1072 , eISSN: 2159-9777

• Journal of Drugs in Dermatology

  Journals

  ISSN: 1545-9616

• Akrydyny jako związki aktywne przeciwnowotworowo = Acridines as antitumor drugs

  Publication

  • A. Dopierała
  • P. Wrosz
  • J. Mazerski

  - Postępy Higieny i Medycyny Doświadczalnej - Year 2011

  Akrydyny należą do grupy policyklicznych związków heteroaromatycznych. Wykazują szeroki zakres aktywności biologicznej obejmujący aktywność przeciwpierwotniakową, przeciwbakteryjną,przeciwwirusową i przeciwnowotworową. Pochodne akrydyny o działaniu przeciwnowotworowym wykazują zróżnicowany mechanizm działania na poziomie molekularnym. Z uzyskanych dotychczas danych wynika, że jednym z podstawowych etapów działania jest tworzenie...

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• Poszukiwanie nowych leków immunosupresyjnych = Quest for new immunosuppressive drugs

  Publication

  • K. Dzierzbicka
  • G. Cholewiński
  • D. Iwaszkiewicz-Grześ
  • P. Trzonkowski

  - Wiadomości Chemiczne - Year 2011

  Niniejsza praca przeglądowa dotyczy znanych leków immunosupresyjnych, a także nowych związków o potencjalnym zastosowaniu klinicznym. Wybrane pochodne przedstawiono z uwzględnieniem mechanizmu ich działania oraz metod otrzymywania.

• Inhibitors of glucosamine-6-phosphate synthase as potential antifungal drugs.

  Publication

  • S. Milewski
  • R. Andruszkiewicz
  • A. Janiak
  • I. Gabriel
  • J. Olchowy
  • R. Wakieć
  • E. Borowski

  - Year 2004

  Przedstawiono stan obecny i perspektywy zastosowania inhibitorów enzymu syntazy GlcN-6-P jako leków skutecznych w leczeniu grzybic układowych. Używając metod modelowania molekularnego zaprojektowano struktury inhibitorów enzymu należących do dwóch grup strukturalnych: analogów glutaminy oraz analogów stanu przejściowego reakcji katalizowanej przez enzym. Opracowano metody syntezy pochodnych zoptymalizowanych inhibitorów, wykazujących...

• Issues in the development of new combinations of blood pressure lowering drugs

  Publication

  • J. Chalmers
  • S. Harrap
  • K. Narkiewicz
  • N. Poulter
  • J. Redon
  • A. Zanchetti
  • G. Mancia

  - JOURNAL OF HYPERTENSION - Year 2010

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• The Effect of Antihypertensive Drugs on NADH in Newly Diagnosed Primary Hypertension

  Publication

  • R. Pawlak-Chomicka
  • T. Krauze
  • P. Uruski
  • J. Piskorski
  • A. Wykretowicz
  • A. Tykarski
  • P. Guzik

  - Cardiology Research and Practice - Year 2022

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• Fentanyl and its derivatives as a group of new psychoactive substances (designer drugs)

  Publication

  • M. Zawadzki
  • K. Nowak

  - Postępy Higieny i Medycyny Doświadczalnej - Year 2018

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• Disposition of Drugs of Abuse and Their Metabolites in Wastewater as a Method of the Estimation of Drug Consumption

  Publication

  • E. Daghir
  • M. J.

  - Current Drug Metabolism - Year 2010

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• Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs

  Publication

  • M. Zygmunt
  • D. Hoinkis
  • J. Hajto
  • M. Piechota
  • B. Skupień-Rabian
  • U. Jankowska
  • S. Kędracka-Krok
  • J. Rodriguez
  • M. Korostyński

  - BMC NEUROSCIENCE - Year 2018

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• Assessment of sleep disorders and use of psychoactive drugs among Polish students

  Publication

  • P. Piotrowski
  • M. Babicki
  • P. Maślanka
  • K. Kotowicz
  • D. Marciniak
  • J. Rymaszewska

  - Psychiatria Polska - Year 2020

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• New data on antihypertensive drugs and risk of cancer: should we worry?

  Publication

  • M. Burnier
  • K. Narkiewicz
  • S. Kjeldsen
  • S. Oparil

  - BLOOD PRESSURE - Year 2019

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• TIME to face the reality about evening dosing of antihypertensive drugs in hypertension

  Publication

  • S. Kjeldsen
  • B. Egan
  • K. Narkiewicz
  • R. Kreutz
  • M. Burnier
  • S. Oparil
  • G. Mancia

  - BLOOD PRESSURE - Year 2023

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• Review of Clinical Pharmacology and Pharmacokinetics, International Edition

  Journals

  ISSN: 1011-6583

• Interaction of selected drugs with food in the group of patients over 60 years of age

  Publication

  • E. Błaszczyk
  • M. Rajska
  • J. Żwirska
  • P. Jagielski
  • M. Schlegel-Zawadzka

  - Family Medicine & Primary Care Review - Year 2015

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• Studies of human and veterinary drugs' fate in environmental solid samples- analytical problems.

  Publication

  • J. Wilga
  • A. Kot-Wasik
  • J. Namieśnik

  - JOURNAL OF CHROMATOGRAPHIC SCIENCE - Year 2008

  W różnych ośrodkach naukowych na całym świecie trwają prace nad poznaniem losu środowiskowego zanieczyszczeń z grupy farmaceutyków. Obecność pozostałości farmaceutycznych w poszczególnych elementach środowiska stanowi nowe wyzwanie zarówno z punktu widzenia technologii oczyszczania wód i ścieków jak i analityków, których zadaniem jest opracowanie nowych metodyk analitycznych. W publikacji przedstawiono problemy z jakimi stykają...

• The Comparison Between the Calculated and HPLC-Predicted Lipophilicity Parameters for Selected Groups of Drugs

  Publication

  • J. Stasiak
  • M. Koba
  • L. Bober
  • P. Kawczak
  • T. Baczek

  - Combinatorial Chemistry & High Throughput Screening - Year 2013

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• Activity evaluation of some psychoactive drugs with the application of QSAR/QSPR modeling methods

  Publication

  • P. Kawczak
  • L. Bober
  • T. Bączek

  - MEDICINAL CHEMISTRY RESEARCH - Year 2018

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• European Society of Hypertension Working Group on Obesity: obesity drugs and cardiovascular outcomes

  Publication

  • J. Jordan
  • M. Schlaich
  • J. Redon
  • K. Narkiewicz
  • F. Luft
  • G. Grassi
  • J. Dixon
  • G. Lambert
  • S. Engeli

  - JOURNAL OF HYPERTENSION - Year 2011

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• Stable and degradable microgels linked with cystine for storing and environmentally triggered release of drugs

  Publication

  • M. Mackiewicz
  • K. Kaniewska
  • J. Romanski
  • E. Augustin
  • Z. Stojek
  • M. Karbarz

  - Journal of Materials Chemistry B - Year 2015

  Environmentally sensitive, degradable microgels based on poly(N-isopropylacrylamide) (pNIPA) crosslinked with the diacryloyl derivative of cystine (BISS) were synthesized by applying surfactant-free emulsion polymerization. pNIPA contributed the sensitivity to temperature to the microgels and the cross-linker made them degradable and sensitive to pH. The morphology of the microgels was investigated by using scanning and transmission...

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• Detrimental effects of chemotherapeutics and other drugs on the endothelium: A call for endothelial toxicity profiling

  Publication

  • T. Wojcik
  • E. Szczesny
  • S. Chlopicki

  - Pharmacological Reports - Year 2015

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• ANTI-CANCER DRUGS

  Journals

  ISSN: 0959-4973 , eISSN: 1473-5741

• Ahmer Bin Hafeez

  People

  I have experience in Microbiology & Computational Biology, particularly bioinformatics, homology modeling, phylogenetics, structural biology, and drug discovery. Currently, my interest lies in translatable omics studies and drug discovery against novel protein targets involved in cancer and infectious diseases and Host-Pathogen PPIs. My aim involves the use of computational methods for the identification of novel targets and to...

• CURRENT OPINION IN INVESTIGATIONAL DRUGS

  Journals

  ISSN: 1472-4472

• EXPERT OPINION ON EMERGING DRUGS

  Journals

  ISSN: 1472-8214 , eISSN: 1744-7623

• Drugs and Cell Therapies in Hematology

  Journals

  ISSN: 2281-4876 , eISSN: 2281-4884

• DRUGS-EDUCATION PREVENTION AND POLICY

  Journals

  ISSN: 0968-7637 , eISSN: 1465-3370

• Nordic Studies on Alcohol and Drugs

  Journals

  ISSN: 1455-0725 , eISSN: 1458-6126

• Expert Opinion on Orphan Drugs

  Journals

  ISSN: 2167-8707

• Drugs - Real World Outcomes

  Journals

  ISSN: 2199-1154

• Chinese Traditional and Herbal Drugs

  Journals

  ISSN: 0253-2670

• Chinese Journal of New Drugs

  Journals

  ISSN: 1003-3734

• MEDICAL LETTER ON DRUGS AND THERAPEUTICS

  Journals

  ISSN: 0025-732X , eISSN: 1523-2859

• Drugs Habits and Social Policy

  Journals

  ISSN: 2752-6739