Search results for: HETEROGENEITY
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Torsional elasticity and energetics of F1-ATPase
PublicationFoF1-ATPase is a rotary motor protein synthesizing ATP from ADP driven by a cross-membrane proton gradient. The proton flow through the membrane-embedded Fo generates the rotary torque that drives the rotation of the asymmetric shaft of F1. Mechanical energy of the rotating shaft is used by the F1 catalytic subunit to synthesize ATP. It was suggested that elastic power transmission with transient storage of energy in some compliant...
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Using creative approaches for discovering biomorphic forms for appropriate human habitation in natural environments. Case study of Kashubian Lake District
PublicationThe research process consisted of studies of natural and cultural conditions of the Kashubian Lake District This is an area of exceptional natural conditions. For centuries, it has seen human habitation with respect to landscape values. Given its extensive forest cover and the lack of heterogeneity of natural conditions, the area has become an interesting inspiration for the author’s original project. The project is aimed at searching...
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Determinants of the incidence of non-academic staff in European and US HEIs
PublicationIn this article, we contribute to the scant literature covering quantitative studies on the determinants of the non-academic staff incidence in higher education institutions by analysing how the proportion of non-academic staff is related to key features such as size, prestige, year of foundation and financial structure of universities. We apply nonlinear regression analysis to compare HEIs across Europe and the USA, taking into...
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Habitat-related patterns of soft-bottom macrofaunal assemblages in a brackish, low-diversity system (southern Baltic Sea)
PublicationCoastal areas provide a high variety of sedimentary habitats that influence the structure of resident fauna even on small geographical scales. Therefore, examinations of spatial variations in benthic assemblages require background knowledge of the environmental and biotic heterogeneity of habitats in order to understand ecological processes in such areas. The effect of habitat-related abiotic and biological variables on macrofaunal...
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RAGE as a Novel Biomarker for Prostate Cancer: A Systematic Review and Meta-Analysis
PublicationThe receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects....
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Metallurgical characterization and high-temperature tensile failure of Inconel 617 alloy welded by GTAW and SMAW—a comparative study
PublicationTwo types of the weld joint of Inconel 617 alloy were produced using gas tungsten arc welding (GTAW) and shielded metal arc welding (SMAW) processes with ERNiCrCoMo-1 filler metal and ENiCrCoMo-1 electrode, respectively. The weld metal showed the segregation of the principle alloying elements like Mo and Cr along the inter-dendritic spaces, triggering the formation of secondary phases. The microstructure characterization of the...
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublicationPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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Comparing the permeability of human and porcine small intestinal mucus for particle transport studies
PublicationThe gastrointestinal mucus layer represents the last barrier between ingested food or orally administered pharmaceuticals and the mucosal epithelium. This complex gel structure plays an important role in the process of small intestinal absorption. It provides protection against hazardous particles such as bacteria but allows the passage of nutrients and drug molecules towards the intestinal epithelium. In scientific research, mucus...
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Ontology-based text convolution neural network (TextCNN) for prediction of construction accidents
PublicationThe construction industry suffers from workplace accidents, including injuries and fatalities, which represent a significant economic and social burden for employers, workers, and society as a whole.The existing research on construction accidents heavily relies on expert evaluations,which often suffer from issues such as low efficiency, insufficient intelligence, and subjectivity.However, expert opinions provided in construction...
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Impact of laser beam welding on mechanical behaviour of 2.25Cr–1Mo (P22) steel
PublicationThe use of welding processes in the manufacturing and repair of structures intended for the energy industry plays a key role in the guarantee of a continuous supply of fossil fuels, which is the basic condition for ensuring energy security. A square butt joint of 10 mm thick plate of 2.25Cr–1Mo (P22) steel was fabricated by autogenous laser beam welding process and then post-weld heat treatment (PWHT) for two sets of process parameters...
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Crack Resistance of Asphalt Concrete Subjected to Environmental Factors
PublicationThe paper presents an analysis of the influence of environmental factors on the cracking susceptibility of asphalt concrete resulting in a change in the durability of asphalt pavement. In order to assess the phenomenon, laboratory tests were carried out taking into account the destructive effects of moisture, freeze-thaw cycle and long-term ageing. The influence of both factors occurring simultaneously was also verified. Due to...
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Numerical Study of Concrete Mesostructure Effect on Lamb Wave Propagation
PublicationThe article presents the results of the numerical investigation of Lamb wave propagation in concrete plates while taking into account the complex concrete mesostructure. Several concrete models with randomly distributed aggregates were generated with the use of the Monte Carlo method. The influence of aggregate ratio and particle size on dispersion curves representing Lamb wave modes was analyzed. The results obtained for heterogeneous...