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Search results for: STAKEHOLDER'S CONCERN
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Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: characteristics of non-enzymatic and glutathione S-transferase-mediated reactions
PublicationUnsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was to investigate the GSH-mediated metabolic pathway of a representative UA, C 2028. GSH supplemented incubations of C-2028 with rat, but not with human, liver...
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Zuschrift zu Stiglat K.: Bauingenieure und ihr Werk: ein Arbeitsbericht. // Stahlbau 73 (2004), H. 11, S. 873-878
PublicationW dyskusji poruszono związki humanistyki, a głównie - poezji, z techniką.
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Morpho-chemical characterization and source apportionment of potentially toxic metal(oid)s from school dust of second largest populous city of Pakistan
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Biogeochemical and mineralogical effects of Fe-P-S dynamics in sediments of continental shelf sea: Impact of salinity, oxygen conditions, and catchment area characteristics
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Poly(amic acid)s vs. polyimides with π-conjugated –N N- units: Cis-trans isomerization reaction and kinetics of thermal imidization
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Peptide dendrimers as antifungal agents and carriers for potential antifungal agent—N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐ diaminopropanoic acid—synthesis and antimicrobial activity
PublicationA series of peptide dendrimers and their conjugates with antimicrobial agent FMDP (N3‐(4‐methoxyfumaroyl)‐(S)‐2,3‐diamino‐propanoic acid) were synthesized. The obtained compounds were tested for the antibacterial and antifungal activity. All novel dendrimers displayed much better activity against the tested strains than FMDP itself. Moreover, their conjugates with FMDP also exhibited antimicrobial activity. The most promising molecules...
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Ocena wpływu przejazdu pojazdów ponadnormatywnych na konstrukcje nawierzchni drogowych. Drogi krajowe i wojewódzkie klas technicznych A, S, GP, G
PublicationZagadnienie dotyczy dopuszczenia przejazdu po drogach publicznych zestawu specjalistycznego Girder Set AL 500, który służy do transportu ponadnormatywnego ładunku. Zestaw pojazdów składa się z naczepy AL 500 o maksymalnej masie całkowitej (wraz z ładunkiem) 715 ton oraz dwóch ciągników balastowych Trojan o masie 48 ton każdy. Zestaw pojazdów o tak dużej masie całkowitej będzie wywierać zdecydowanie większe oddziaływanie na konstrukcję...
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Anticancer and antimicrobial properties of novel η6-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization
PublicationRuthenium(II) complexes are lately of great scientific interest due to their chemotherapeutic potential asanticancer and antimicrobial agents. Here we present the synthesis of new pyrazole carbothioamidederivatives and their four arene–ruthenium complexes. The title compounds were characterized with theapplication of IR, NMR, mass spectrometry, elemental analysis and X-ray diffraction. Additionally, for newcomplexes DFT calculations...
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Bio‑derived polyurethanes obtained by non‑isocyanate route using polyol‑based bis(cyclic carbonate)s—studies on thermal decomposition behavior
PublicationNon-isocyanate polyurethanes (NIPUs) constitute one of the most prospective groups of eco-friendly materials based on their phosgene-free synthesis pathway. Moreover, one of the steps of their obtaining includes the use of carbon dioxide (CO 2 ), which allows for the promotion of the development of carbon dioxide capture and storage technologies. In this work, non- isocyanate polyurethanes were obtained via three-step synthesis...
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(CA)n Microsatellite polymorphism of ERBB-1 in breast cancer
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Biological Effects of Cold Atmospheric Pressure Plasma on Skin Cancer
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The p53-mediated cytotoxicity of photodynamic therapy of cancer: Recent advances
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Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways
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Clinical Relevance of Circulating Tumor Cells in Prostate Cancer Management
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C-reactive Protein as a Diagnostic and Prognostic Factor of Endometrial Cancer
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Microbiota-derived metabolites in colorectal cancer patients in preoperative period
PublicationShort-chain fat-ty acids (SCFAs) are microbial derived metabo-lites, which have multiple beneficial properties. The amount of SCFAs depends on several fac-tors, such as age, diet (mainly intake of dietary fiber), and overall health condition. The normal proportion between SCFAs is 3:1:1 for acetate, proprionate and butyrate, respectively. In col-orectal cancer (CRC) patients, microbiota alter-ations have been shown. Consequently,...
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A deletion in CHEK2 of 5,395 bp predisposes to breast cancer in Poland
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XPD Common Variants and their Association with Melanoma and Breast Cancer Risk
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Common variants of xeroderma pigmentosum genes and prostate cancer risk
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An inherited NBN mutation is associated with poor prognosis prostate cancer
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Cancer Familial Aggregation (CFA) and G446A polymorphism in ARLTS1 gene
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The presence of prostate cancer at biopsy is predicted by a number of genetic variants
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Serum mass profile signature as a biomarker of early lung cancer
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Sulforaphane inhibits growth of phenotypically different breast cancer cells
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Notch signalling pathway as an oncogenic factor involved in cancer development
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The role of Snail1 transcription factor in colorectal cancer progression and metastasis
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Nuclear quantum effects in a HIV/cancer inhibitor: The case of ellipticine
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Pemphigus foliaceus in a patient with skin cancer with metastases to lymph nodes
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VEGF – targeted therapy for the treatment of cervical cancer – literature review
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Analysis of 5-Methylcytosine in DNA of Breast and Colon Cancer Tissues
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Survival time prognosis under a Markov model of cancer development
PublicationIn this study we look at a breast cancer data set of women from Pomerania region collected in year 1987-1992 in the Medical University of Gdańsk. We analyze the clinical risk factors in conjunction with Markov model of cancer development. We evaluate Artificial Neural Network (ANN) survival time prediction via a simulation study.
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The effects of RNA editing in cancer tissue at different stages in carcinogenesis
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Bladder cancer detection using a peptide substrate of the 20S proteasome
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Extracellular miRNAs as Biomarkers of Head and Neck Cancer Progression and Metastasis
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C-reactive protein as a diagnostic and prognostic factor of endometrial cancer
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Metabolic profiling of pteridines for determination of potential biomarkers in cancer diseases
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Comparison of Pteridine Normalization Methods in Urine for Detection of Bladder Cancer
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The Role of miRNA-7 in the Biology of Cancer and Modulation of Drug Resistance
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The ICTBioMed NCIP Hub: Cancer research in a science gateway consortium
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Folate/homocysteine metabolism and lung cancer risk among smokers
PublicationBackground: Folate and homocysteine are involved in DNA synthesis and methylation processes, which are deregulated during carcinogenesis. Objectives: The aim of this study was to assess the relationship between folate/homocysteine concentrations, the functional polymorphisms of folate/homocysteine genes and lung cancer risk among cigarette smokers. Study design: The study included 132 lung cancer patients and 396 controls from...
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Diamond Nanofilm Normalizes Proliferation and Metabolism in Liver Cancer Cells
PublicationPurpose: Surgical resection of hepatocellular carcinoma can be associated with recurrence resulting from the degeneration of residual volume of the liver. The objective was to assess the possibility of using a biocompatible nanofilm, made of a colloid of diamond nanoparticles (nfND), to fill the side after tumour resection and optimize its contact with proliferating liver cells, minimizing their cancerous transformation. Methods:...
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Stage I non-small-cell lung cancer: long-term results of lobectomy versus sublobar resection from the Polish National Lung Cancer Registry†
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New Unsymmetrical Bisacridine Derivatives Noncovalently Attached to Quaternary Quantum Dots Improve Cancer Therapy by Enhancing Cytotoxicity toward Cancer Cells and Protecting Normal Cells
PublicationThe use of nanoparticles for the controlled drug delivery to cells has emerged as a good alternative to traditional systemic delivery. Quantum dots (QDs) offer potentially invaluable societal benefits such as drug targeting and in vivo biomedical imaging. In contrast, QDs may also pose risks to human health and the environment under certain conditions. Here, we demonstrated that unique combination of nanocrystals core components...
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Holonowe systemy produkcyjne. W: Inżynieria zarządzania przedsięwzięciami.Red. L. Zawadzka. Gdańsk: P. Gdań.**2003 s. 53-58 bibliogr. 6 poz.
PublicationNiniejszy artykuł pokazuje możliwości stosowania technologii holonowych welastycznej produkcji.
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Bamboo-biochar and hydrothermally treated-coal mediated geochemical speciation, transformation and uptake of Cd, Cr, and Pb in a polymetal(iod)s-contaminated mine soil
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Contribution of non-carbonate inorganic and organic alkalinity to total measured alkalinity in pore waters in marine sediments (Gulf of Gdansk, S-E Baltic Sea)
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Stan graniczny nośności dźwigara żelbetowego mostu na zginanie według norm PN-EN 1992-2 oraz PN-S-10042:1991
PublicationPraca włącza się w bogaty w ostatnich latach w krajowym piśmiennictwie nurt porównań dwóch generacji norm projektowania mostów z betonu: polskiej - wycofanej, aczkolwiek powszechnie stosowanej oraz europejskiej – wciąż jeszcze wdrażanej do praktyki projektowej. Nowością w stosunku do dotychczasowych publikacji polskich jest szersze ujęcie różnic pomiędzy obydwiema generacjami norm. Poza rozpatrywanymi przez wielu autorów różnicami...
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Stan graniczny nośności dźwigara żelbetowego mostu na zginanie według norm PN-EN 1992-2 oraz PN-S-10042:1991
PublicationPraca włącza się w bogaty w ostatnich latach w krajowym piśmiennictwie nurt porównań dwóch generacji norm projektowania mostów z betonu: polskiej - wycofanej, aczkolwiek powszechnie stosowanej oraz europejskiej – wciąż jeszcze wdrażanej do praktyki projektowej. Nowością w stosunku do dotychczasowych publikacji polskich jest szersze ujęcie różnic między obydwiema generacjami norm. Poza rozpatrywanymi przez wielu autorów różnicami...
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Probabilistic concept of defining the situations possible to occur during operation of floating docks
PublicationW artykule zasygnalizowana została możliwość oszacowania bezpieczeństwa doków pływajacych, w wyniku zastosowania teorii procesów semimarkowskich, zarówno w fazie projektowania jak też eksploatacji. Przedstawiono opis formalny sytuacji, jakie mogą zaistnieć podczas funkcjonowania (działania) doków pływających, zarówno budowlanych jak również remontowych. Wyróżniono takie sytuacje jak: normalna, skomplikowana, niebezpieczna, awaryjna...
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A concept of application of the technical state change models of devices inship operation process
PublicationPrzedstawiono warunki zastosowania modeli zmian stanu technicznego urządzeń siłowni okrętowej w trakcie eksploatacji statku, koncepcję prognozowania zasobu godzin pracy urządzeń w zmiennych warunkach pływania oraz planowania obsług profilaktycznych.