Filters
total: 329
filtered: 274
-
Catalog
Chosen catalog filters
Search results for: John Sinclair
-
Elemental and water-insoluble organic carbon in Svalbard snow: a synthesis of observations during 2007–2018
PublicationLight-absorbing carbonaceous aerosols emitted by biomass or fossil fuel combustion can contribute to amplifying Arctic climate warming by lowering the albedo of snow. The Svalbard archipelago, being near to Europe and Russia, is particularly affected by these pollutants, and improved knowledge of their distribution in snow is needed to assess their impact. Here we present and synthesize new data obtained on Svalbard between 2007...
-
Cancer-selective, single agent chemoradiosensitising gold nanoparticles
PublicationTwo nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and...
-
Inhibitor kinazy Brutona u chorych z nawrotowym lub opornym na leczenie chłoniakiem z komórek płaszcza – wyniki międzynarodowego, wieloośrodkowego, badania II fazy z ibrutynibem (PCI-32765) – EHA Encore
Publication -
Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases
Publication -
Considerations for artificial intelligence clinical impact in oncologic imaging: an AI4HI position paper
Publication -
Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study
Publication -
Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 study
Publication -
Corrigendum: Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses
Publication -
Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses
Publication -
Ibrutinib as Treatment for Patients With Relapsed/Refractory Follicular Lymphoma: Results From the Open-Label, Multicenter, Phase II DAWN Study
Publication -
Lenalidomide versus investigator's choice in relapsed or refractory mantle cell lymphoma (MCL-002; SPRINT): a phase 2, randomised, multicentre trial
Publication -
Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial
Publication -
Crystal growth of CsCl-type Yb0.24Sn0.76Ru
PublicationWzrost kryształów o stechiometrii Yb0.24Sn0.76Ru został przeprowadzony metodą topnikową. Kryształy poddano badaniom dyfrakcyjnym a także mikroskopii elektornowej. Yb0.24Sn0.76Ru krystalizuje w sześciennej strukturze typu chlorku cezu (CsCl).
-
Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin’s Lymphoma
Publication -
Correlation between in vitro and in vivo data on food digestion. What can we predict with static in vitro digestion models?
PublicationDuring the last decade, there has been a growing interest in understanding food's digestive fate in order to strengthen the possible effects of food on human health. Ideally, food digestion should be studied in vivo on humans but this is not always ethically and financially possible. Therefore, simple in vitro digestion models mimicking the gastrointestinal tract have been proposed as alternatives to in vivo experiments. Thus,...
-
Expertise: No Longer a Sine Qua Non for Guideline Authors?
Publication -
Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma
Publication -
Impacts of salvage logging on biodiversity: A meta-analysis
Publication -
Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
PublicationThe structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA...
-
Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea
PublicationAmong nanomaterials, silver nanoparticles (AgNPs) have the broadest and most commercial applications due to their antibacterial properties, highlighting the need for exploring their potential toxicity and underlying mechanisms of action. Our main aim was to investigate whether AgNPs exert toxicity by inducing oxidative damage to DNA in human kidney HEK 293 cells. In addition, we tested whether this damage could be counteracted...
-
Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria
PublicationIn eukaryotic cells, different organelles interact at membrane contact sites stabilized by tethers. Mitochondrial mitofusin 2 (MFN2) acts as a membrane tether that interacts with an unknown partner on the endoplasmic reticulum (ER). In this work, we identified the MFN2 splice variant ERMIT2 as the ER tethering partner of MFN2. Splicing of MFN2 produced ERMIT2 and ERMIN2, two ER-specific variants. ERMIN2 regulated ER morphology,...
-
Reply
Publication -
Expertise
Publication -
Direct brain stimulation modulates encoding states and memory performance in humans
PublicationPeople often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting,...
-
Progress in upscalingMiscanthusbiomass production for the European bio-economy with seed-based hybrids
Publication -
Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age
Publication -
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis
Publication -
A standardised static in vitro digestion method suitable for food – an international consensus
PublicationSimulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of macronutrients (e.g. lipids, proteins and carbohydrates) are used for screening and building...
-
Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes—an international multicentre retrospective study
Publication -
Belief in a zero-sum game and subjective well-being across 35 countries
Publication -
Modeling SARS‐CoV‐2 proteins in the CASP‐commons experiment
PublicationCritical Assessment of Structure Prediction (CASP) is an organization aimed at advancing the state of the art in computing protein structure from sequence. In the spring of 2020, CASP launched a community project to compute the structures of the most structurally challenging proteins coded for in the SARS-CoV-2 genome. Forty-seven research groups submitted over 3000 three-dimensional models and 700 sets of accuracy estimates on...
-
INFOGEST static in vitro simulation of gastrointestinal food digestion
PublicationDeveloping a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus...
-
Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline
Publication -
Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient
Publication -
Continuation of the ESH-CHL-SHOT trial after publication of the SPRINT
Publication -
Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial
Publication -
Going to extremes – a metagenomic journey into the dark matter of life
Publication -
Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization
Publication -
13th International Conference on Conservative Management of Spinal Deformities and First Joint Meeting of the International Research Society on Spinal Deformities and the Society on Scoliosis Orthopaedic and Rehabilitation Treatment – SOSORT-IRSSD 2016 meeting
Publication -
Country‐level and individual‐level predictors of men's support for gender equality in 42 countries
Publication -
Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial
Publication -
18th European Symposium on Radiopharmacy and Radiopharmaceuticals
Publication -
Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
Publication -
Architektura a dekonstrukcja. Przypadek Petera Eisenmana i Bernarda Tschumiego
PublicationArchitecture and Deconstruction Case of Peter Eisenman and Bernard Tschumi Introduction Towards deconstruction in architecture Intensive relations between philosophical deconstruction and architecture, which were present in the late 1980s and early 1990s, belong to the past and therefore may be described from a greater than...
-
Prospective Observational Study on acute Appendicitis Worldwide (POSAW)
Publication -
2018 ESC/ESH Guidelines for the management of arterial hypertension
Publication -
Gendered Self-Views Across 62 Countries: A Test of Competing Models
Publication -
Psychometric Properties and Correlates of Precarious Manhood Beliefs in 62 Nations
Publication -
Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
Publication -
Diversity and ethics in trauma and acute care surgery teams: results from an international survey
Publication