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Search results for: DRUGS DOSAGE
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Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC–MS/MS in case of severe intoxications
PublicationThis paper describes cases of poisoning caused by new psychoactive substances such as: 25BNBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and 4-CMC (1-(4-chlorophenyl)-2-(methylamino)-1-propanone). The analytical procedure includes rapid and selective method for the extraction and determination of 4-CMC and 25B-NBOMe in blood samples using UPLC–MS/MS technique. To the best of our knowledge,this is...
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High-Dose Testosterone Propionate Treatment Reverses the Effects of Endurance Training on Myocardial Antioxidant Defenses in Adolescent Male Rats
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Population pharmacokinetics of standard-dose meropenem in critically ill patients on continuous renal replacement therapy: a prospective observational trial
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Three-dimensional visualization and measurement of conformal dose distributions using magnetic resonance imaging of bang polymer gel dosimeters
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Spectral characteristic of high-dose high-temperature emission from LiF:Mg,Cu,P (MCP-N) TL detectors
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Fuzzy Control 2023
e-Learning CoursesKurs do przedmiotu "Fuzzy Control" na sem letni 2023, drugi stopień
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Fuzzy Control 2022
e-Learning CoursesKurs do przedmiotu "Fuzzy Control" na sem letni 2022, drugi stopień
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Sterowanie Rozmyte 2023
e-Learning CoursesKurs do przedmiotu "Sterowanie rozmyte" na sem letni 2023, drugi stopień
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Sterowanie Rozmyte 2022
e-Learning CoursesKurs do przedmiotu "Sterowanie rozmyte" na sem letni 2022, drugi stopień
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Fuzzy Control 2024
e-Learning CoursesKurs do przedmiotu "Fuzzy Control" na sem letni 2024, drugi stopień
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Sterowanie Rozmyte 2024
e-Learning CoursesKurs do przedmiotu "Sterowanie rozmyte" na sem letni 2024, drugi stopień
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In vivoevaluation of the CB1allosteric modulator LDK1258 reveals CB1-receptor independent behavioral effects
PublicationIn the present study, we examined whether LDK1258, which produces strong CB1receptor allosteric effects ininvitroassays, would elicitin vivoeffects consistent with allosteric activity. In initial studies, LDK1258 reducedfood consumption and elicited delayed antinociceptive effects in the chronic constrictive injury of the sciaticnerve (CCI) model of neuropathic pain, which unexpectedly emerged 4 h post-injection. UPLC-MS/MS analysisquantified...
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Study of the effect of residues of pharmaceuticals on the environment on the example of bioassay Microtox®
PublicationResidues of pharmaceuticals present in the aqueous environment can be found in a mixture of different substances wherein drugs not remain inert with respect to each other. In such mixtures a phenomenon of synergism or antagonism may occur, which can contribute to increase or decrease the overall toxicity of the mixture of drugs. Pharmaceuticals namely: diclofenac (sodium salt), oxyteracycline hydrochloride, fluoxetine hydrochloride,...
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‘Acridines’ as New Horizons in Antifungal Treatment
PublicationFrequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide. The repertoire of antifungal chemotherapeutic agents is very limited. Although new antifungal drugs such as lanosterol 14α-demethylase and β-glucan synthase inhibitors have been introduced into clinical...
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Historia filozofii z elementami historii matematyki
e-Learning CoursesHistoria filozofii z elementami historii matematyki. Drugi semestr Matematyki, pierwszego stopnia
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Projekt Zespołowy I 2024
e-Learning CoursesProjekt zespołowy I dla studentów fizyki, drugi stopień, sem I
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Activation of Metabotropic Glutamate Receptor (mGlu2) and Muscarinic Receptors (M1, M4, and M5), Alone or in Combination, and Its Impact on the Acquisition and Retention of Learning in the Morris Water Maze, NMDA Expression and cGMP Synthesis
PublicationThe Morris water maze (MWM) is regarded as one of the most popular tests for detecting spatial memory in rodents. Long-term potentiation and cGMP synthesis seem to be among the crucial factors involved in this type of learning. Muscarinic (M1, M4, and M5 receptors) and metabotropic glutamate (mGlu) receptors are important targets in the search for antipsychotic drugs with the potency to treat cognitive disabilities associated with...
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Investigation of sinonasal anatomy via low-dose multidetector CT examination in chronic rhinosinusitis patients with higher risk for perioperative complications
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Radiation dose distributions in three dimensions from tomographic optical density scanning of polymer gels: I. Development of an optical scanner
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SU‐E‐T‐103: Three‐Dimensional Measurements of Dose and LET from a Proton Beam via Polymer Gel Dosimetry
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Application of ferric chloride for arsenic removal in the integrated process: coagulation/microfiltration
PublicationThe study presents results of using iron coagulation integrated with microfiltration to remove arsenic from water. Tested samples of natural groundwater contained approximately 32 μg/L of arsenic, 0.13 mg/L of iron and 0.085 mg/L of manganese. As a coagulant the aqueous solution of ferric chloride was dosed in portions from 1.0 to 10.5 mg/L. In the research microfiltration membranes with 400 kDa MWCO were used. Tests indicated...
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Polyacrylamide substrate viscosity impact on temozolomide activity in glioblastoma cells by flow cytometry and rheological measurements
Open Research DataDataset includes raw data on cell lines LN-229 and LN-18 treated with temozolomide measured by flow cytometry, rheometry and cell projections. It also includes calculations necessary for creation of figures and conclusions based on those figures in the publication titiled: "Substrate viscosity impairs temozolomide-mediated inhibition of glioblastoma...
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Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes
PublicationMany anticancer drugs reduce the integrity of DNA, forming strand breaks. This can cause mutations and cancer or cell death if the lesions are not repaired. Interestingly, DNA repair-deficient cancer cells (e.g., those with BRCA1/2 mutations) have been shown to exhibit increased sensitivity to chemotherapy. Based on this observation, a new therapeutic approach termed 'synthetic lethality' has been developed, in which radiation...
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Antimicrobal and ostheointegration activity of bone cement contains nanometals
PublicationPurpose: One of the major problems in bone surgery are infections – especially thoseoccurring in the course of the operating on the patients with lowered immunity system,because they carry the danger of complications. In the Mechanical Department of TechnicalUniversity of Gdansk, there has been carried the research with the use of bone cement andmetal nanoparticles.Design/methodology/approach: The bone cement was used without supplement...
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Determination of bromhexine and its metabolites in equine serum samples by liquid chromatography – Tandem mass spectrometry: Applicability to the elimination study after single oral dose
PublicationBromhexine (BH), expectorant used in the treatment of respiratory disorders associated with viscid or excessive mucus, is not permitted for use in the competing horse by many authorities in horseracing and Olympic disciplines. Metabolic studies are of the great importance in anti-doping field because they allow for updating the selection of the most appropriate markers for prohibited substances, such as metabolites present at higher...
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mikrokontrolery stm8s - pierwsze kroki (2)
PublicationArtykuł zawiera drugą część krótkiego kursu programowania mikrokontrolerów STM8S
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Two novel nucleoside ester derivatives of chlorambucil as potential antileukemic prodrugs: a preliminary study
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Fatal iatrogenic vinorelbine poisoning
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Preclinical toxicological examination of a putative prostate cancer-specific 4-methyl-1-nitroacridine derivative in rodents
PublicationW pracy przedstawiono wyniki przedklinicznych badań toksykologicznych zwiazków C-1748 i C-857 na szczurach Copenhagen i myszach BALB/c, po podaniu dootrzewnowym lub dożylnym. U myszy dawki letalne (LD50) dla C-1748 wynosiły odpowiednio 9 i 13,4 mg/kg w porównaniu z 2,2 i 3 mg/kg dla C-857. U szczurów po podaniu dootrzewnowym lub dożylnym dla C-1748 dawki LD50 wynosiły odpowiednio 4 i 1,3 mg/kg. Nie stwierdzono zmian w liczbie komórek...
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The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases
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Outcome and prognostic factors in advanced Hodgkin's disease treated with high-dose chemotherapy and autologous stem cell transplantation: a study of 341 patients
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Acute decompensated heart failure as a reason of premature chemotherapy discontinuation may be independent of a lifetime doxorubicin dose in lymphoma patients with cardiovascular disorders
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Time- and Dose-Dependent Effects of 17 Beta-Estradiol on Short-Term, Real-Time Proliferation and Gene Expression in Porcine Granulosa Cells
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3D dose verification with polymer gel detectors of brain-spine match line for proton pencil beam cranio-spinal: A preliminary study
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Performance evaluation of an improved optical computed tomography polymer gel dosimeter system for 3D dose verification of static and dynamic phantom deliveries
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Efficacy of high-dose corticosteroid-based treatment for chronic lymphocytic leukemia patients with p53 abnormalities in the era of B-cell receptor inhibitors
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Radial distribution of dose within heavy charged particle tracks – Models and experimental verification using LiF:Mg,Cu,P TL detectors
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Visualizing the Dose Distribution and Linear Energy Transfer by 1D and 2D ESR Imaging: A Potassium Dithionate Dosimeter Irradiated with C6+ and N7+ Ions
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Bisphenols (A, S, and F) affect the basic hormonal activity determined for pharmaceuticals – Study of Saccharomyces cerevisiae
PublicationPharmaceuticals and analogs of bisphenol A (BPA) are increasingly threatening environmental pollutants. In this study, mixtures of selected pharmaceuticals (diclofenac sodium salt, chloramphenicol, oxytetracycline hydrochloride, fluoxetine hydrochloride, estrone, ketoprofen, progesterone, gemfibrozil and androstenedione) were prepared with BPA and its two analogs (namely, bisphenols F and S) at such ratios to reflect environmentally...
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Sposoby Realizacji Maszyn Wirtualnych Zintegrowanych z Procesorem
PublicationW pracy przedstawiono dwa proponowane sposoby realizacji maszyny wirtualnej zintegrowanej z procesorem. Pierwszy z nich opiera się o rozbudowaną pamięć podręczną instrukcji, drugi bazuje na mechanizmie zarządzania pamięcią przez procesor. Pierwszy z przedstawionych sposobów jest dobrym rozwiązaniem do zastosowania w systemach wbudowanych, zaś drugi nadaje się do stosowania z pełnowymiarowymi systemami operacyjnymi.
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DNA methylation in cancer development, diagnosis and therapy-multiple opportunities for genotoxic agents to act as methylome disruptors or remediators
PublicationThe role of DNA methylation and recently discovered hydroxymethylation in the function of the human epigenome is currently one of the hottest topics in the life sciences. Progress in this field of research has been further accelerated by the discovery that alterations in the methylome are not only associated with key functions of cells and organisms, such as development, differentiation and gene expression, but may underlie a number...
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Gabriela Rembarz dr inż. arch.
PeopleGabriela Rembarz inżynier-architekt, urbanista, naukowiec, dydaktyk i aktywna projektantka, jest doktorem nauk technicznych w dyscyplinie architektura i urbanistyka, Ukończyła studia magisterskie na Wydziale Architektury i Urbanistyki Politechniki Gdańskiej, uzupełniając je specjalizacją w Ochronie Środowiska w ramach międzyuczelnianego CENVIG Center of Environmental Studies (Politechnika Gdańska) akredytowanego przez Roskilde...
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Consequences of New Approach of Chemical Stability Tests of Active Pharmaceutical Ingredients (APIs)
PublicationThere is a great need of broaden look on stability tests of active pharmaceuticalingredients (APIs) in comparison with current requirements contained in pharmacopeia.By usage of many modern analytical methods the conception of monitoring the changesof APIs during initial stage of their exposure to harmful factors has been developed. Newknowledge must be acquired in terms of identification of each degradation...
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Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublicationInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
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Engineering method of tire rolling resistance evaluation
PublicationTire rolling resistance is one of the most difficult tire parameters to measure. The reason is that for modern tires the force of rolling resistance corresponds to 0.5–1% of tire load, thus measurements of very small forces must be performed in a heavily loaded system. This constitutes great problems, especially in road conditions. Laboratory measurements are easier to perform, as the environment may be better controlled, but roadwheel...
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Computational collective intelligence for enterprise information systems
PublicationCollective intelligence is most often understood as a kind of intelligence which arises on the basis of a group (collective) of autonomous unites (people, systems) which is taskoriented. There are two important aspects of an intelligent collective: The cooperation aspect and the competition aspect (Levy 1997). The first of them means the possibility for integrating the decisions made by the collective members for creating the decision of...
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Pisemna opinia biegłego z dziedziny chemii analitycznej na okoliczności szczegółowo wskazane w postanowieniu z dnia 27 lipca 2009.
PublicationEkspertyza dla Sądu Okręgowego w Toruniu - Wydział Drugi Karny, na okoliczność sfałszowania oleju napędowego.
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Quantification of Compatibility Between Polymeric Excipients and Atenolol Using Principal Component Analysis and Hierarchical Cluster Analysis
PublicationAn important challenge to overcome in the solid dosage forms technology is the selection of the most biopharmaceutically efficient polymeric excipients. The excipients can be selected, among others, by compatibility studies since incompatibilities between ingredients of the drug formulations adversely affect their bioavailability, stability, efficacy, and safety. Therefore, new, fast, and reliable methods for detecting incompatibility...
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- Telomeres as targets for anticancer drug development - a computational approach
ProjectsProject realized in Faculty of Chemistry according to Homing Plus/2011-4/3 agreement from 2012-03-29
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COLON, Descending colon - Female, 66 - Tissue image [9020730024811751]
Open Research DataThis is the histopathological image of COLON tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.