Antifungal Activity of Homoaconitate and Homoisocitrate Analogs - Publikacja - MOST Wiedzy

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Antifungal Activity of Homoaconitate and Homoisocitrate Analogs

Abstrakt

Thirteen structural analogs of two initial intermediates of the L-alpha-aminoadipate pathway of L-lysine biosynthesis in fungi have been designed and synthesized, including fluoro- and epoxy-derivatives of homoaconitate and homoisocitrate. Some of the obtainedcompounds exhibited at milimolar range moderate enzyme inhibitory properties against homoaconitase and/or homoisocitrate dehydrogenase of Candida albicans. The structural basis for homoisocitrate dehydrogenase inhibition was revealed by molecular modeling ofthe enzyme-inhibitor complex. On the other hand, the trimethyl ester forms of some of the novel compounds exhibited antifungal effects. The highest antifungal activity was found for trimethyl trans-homoaconitate, which inhibited growth of some human pathogenicyeasts with minimal inhibitory concentration (MIC) values of 16-32 mcg/mL.

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
MOLECULES nr 17, strony 14022 - 14036,
ISSN: 1420-3049
Język:
angielski
Rok wydania:
2012
Opis bibliograficzny:
Milewska M., Prokop M., Gabriel I., Wojciechowski M., Milewski S.: Antifungal Activity of Homoaconitate and Homoisocitrate Analogs// MOLECULES. -Vol. 17, nr. iss. 12 (2012), s.14022-14036
Weryfikacja:
Politechnika Gdańska

wyświetlono 11 razy

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