Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase


The antifungal activity of 5‐hydroxy‐4‐oxo‐L‐norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV‐containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI‐1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL−1 range. This activity was not affected by multidrug resistance that is caused by overexpression of genes encoding drug efflux proteins. The mechanism of antifungal action of HONV dipeptides involved uptake by the oligopeptide transport system, subsequent intracellular cleavage by cytosolic peptidases, and inhibition of homoserine dehydrogenase by the released HONV. The relative transport rates determined the anticandidal activity of HONV dipeptides.


Informacje szczegółowe

Kategoria: Publikacja w czasopiśmie
Typ: artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w: JOURNAL OF PEPTIDE SCIENCE nr 24, wydanie 1, strony 1 - 10,
ISSN: 1075-2617
Język: angielski
Rok wydania: 2018
Opis bibliograficzny: Skwarecki A., Schielmann M., Martynow D., Kawczyński M., Wiśniewska A., Milewska M., Milewski S.: Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase// JOURNAL OF PEPTIDE SCIENCE. -Vol. 24, iss. 1 (2018), s.1-10
DOI: 10.1002/psc.3060
wyświetlono 13 razy
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