Aptamer based tools for environmental and therapeutic monitoring: A review of developments, applications, future perspectives - Publikacja - MOST Wiedzy

Wyszukiwarka

Aptamer based tools for environmental and therapeutic monitoring: A review of developments, applications, future perspectives

Abstrakt

Nucleic acids in the form of aptamers play a growing and significant role in the targeted and rapid analysis of environmental sample composition and medical analyses. In this paper, the review of both aptamers synthesis methods as well as application of these short chain oligonucleotides (with critical comments on their strong and weak features) are given. The first ones include: systematic evolution of ligands by exponential enrichment (SELEX), high throughput aptamer identification screen (HAPIscreen), and a non-equilibrium capillary electrophoresis of equilibrium mixture (NECEEM). Afterwards, manuscript describes variety of sensors and biotests utilizing aptamers as active part of its action starting from electrochemical aptasensors, through optical to piezo-electric ones. Described biotests present basic developments in enzymelinked apta-sorbent assays (ELASA) that can be performed with different variations (enzyme-linked aptamer assay (ELAA), enzyme-linked oligonucleotide assay (ELONA) and aptamerlinked immobilized sorbent assay (ALISA)). Next, the review presents advantages and drawbacks of recent aptameric developments in versatile laboratory applications, namely medical ones, as well as analytical and bioassays. Utilitarian development of aptasensors and aptamers would strongly benefit from an assembly of interdisciplinary teams containing chemists, physicists, biologists, medical doctors, and material and electronic scientists, to determine the most effective application methodologies.

Cytowania

  • 5 7

    CrossRef

  • 0

    Web of Science

  • 5 8

    Scopus

Cytuj jako

Pełna treść

pobierz publikację
pobrano 245 razy
Wersja publikacji
Accepted albo Published Version
Licencja
Copyright (2019 Taylor & Francis Group, LLC)

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY nr 50, strony 816 - 867,
ISSN: 1064-3389
Język:
angielski
Rok wydania:
2020
Opis bibliograficzny:
Kudłak B., Wieczerzak M.: Aptamer based tools for environmental and therapeutic monitoring: A review of developments, applications, future perspectives// CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY -Vol. 50,iss. 8 (2020), s.816-867
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1080/10643389.2019.1634457
Źródła finansowania:
  • projekt Miniatura nr 2017/01/X/ST4/00474
Weryfikacja:
Politechnika Gdańska

wyświetlono 327 razy

Publikacje, które mogą cię zainteresować

Meta Tagi