Cold plasma treatment of tannic acid as a green technology for the fabrication of advanced cross-linkers for bioactive collagen/gelatin hydrogels

Beata Kaczmarek-Szczepańska; Marcin Wekwejt; Anna Pałubicka; Anna Michno; Lidia Zasada; Amir M. Alsharabasy

doi:10.1016/j.ijbiomac.2023.128870

Cold plasma treatment of tannic acid as a green technology for the fabrication of advanced cross-linkers for bioactive collagen/gelatin hydrogels

Abstrakt

Tannic acid (TA) is a natural compound studied as the cross-linker for biopolymers due to its ability to form hydrogen bonds. There are different methods to improve its reactivity and effectiveness to be used as a modifier for biopolymeric materials. This work employed plasma to modify tannic acid TA, which was then used as a cross-linker for fabricating collagen/gelatin scaffolds. Plasma treatment did not cause any significant changes in the structure of TA, and the resulting oxidized TA showed a higher antioxidant activity than that without treatment. Adding TA to collagen/gelatin scaffolds improved their mechanical properties and stability. Moreover, the obtained plasma-treated TA-containing scaffolds showed antibacterial properties and were non-hemolytic, with improved cytocompatibility towards human dermal fibroblasts. These results suggest the suitability of plasma treatment as a green technology for the modification of TA towards the development of advanced TA-crosslinked hydrogels for various biomedical applications.

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Autorzy (6)

Beata Kaczmarek-Szczepańska dr
Marcin Wekwejt dr inż.
Anna Pałubicka dr
Anna Michno dr hab. n. med.
Lidia Zasada
Amir M. Alsharabasy

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Kategoria:

Publikacja w czasopiśmie

Typ:

artykuły w czasopismach

Opublikowano w:

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN: 0141-8130

Język:

angielski

Rok wydania:

2024

Opis bibliograficzny:

Kaczmarek-Szczepańska B., Wekwejt M., Pałubicka A., Michno A., Zasada L., Alsharabasy A. M.: Cold plasma treatment of tannic acid as a green technology for the fabrication of advanced cross-linkers for bioactive collagen/gelatin hydrogels// INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES -, (2023), s.128870-

DOI:

10.1016/j.ijbiomac.2023.128870

Źródła finansowania:

Nicolaus Copernicus University in Torun (Grant number 2823/2020 IDUB) and Science Foundation Ireland (SFI), co-funded under the European Regional Development Fund under Grant number 13/RC/2073_P2.

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