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The characterization of collagen‑based scaffolds modified with phenolic acids for tissue engineering application
Abstrakt
The aim of the experiment was to study the morphology of collagen-based scaffolds modified by caffeic acid, ferulic acid, and gallic acid, their swelling, and degradation rate, as well as the biological properties of scaffolds, such as antioxidant activity, hemo- and cytocompatibility, histological observation, and antibacterial properties. Scaffolds based on collagen with phenolic acid showed higher swelling rate and enzymatic stability compared to scaffolds based on pure collagen, and the radical scavenging activity was in the range 85–91%. All scaffolds were non-hemolytic and compatible with surrounding tissues. Collagen modified by ferulic acid showed potentially negative effects on hFOB cells as a significantly increased LDH release was found, but all of the studied materials had antimicrobial activity against Staphylococcus aureus and Escherichia coli. It may be assumed that phenolic acids, such as caffeic, ferulic, and gallic acid, are modifiers and provide novel biological properties of collagen-based scaffolds. This paper provides the summarization and comparison of the biological properties of scaffolds based on collagen modified with three different phenolic acids.
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Autorzy (11)
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Beata Kaczmarek-Szczepańska dr
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Izabela Polkowska Prof. dr hab.
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Marcin Małek dr inż.
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Janusz Kluczyński
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Katarzyna Paździor-Czapula dr
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Michno Anna dr
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Anna Ronowska dr hab. n. med.
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Anna Pałubicka dr
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Beata Nowicka
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Iwona Otrocka-Domagała dr hab.
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Pełna treść
- Wersja publikacji
- Accepted albo Published Version
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1038/s41598-023-37161-6
- Licencja
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Informacje szczegółowe
- Kategoria:
- Publikacja w czasopiśmie
- Typ:
- artykuły w czasopismach
- Opublikowano w:
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Scientific Reports
ISSN: 2045-2322 - Język:
- angielski
- Rok wydania:
- 2023
- Opis bibliograficzny:
- Kaczmarek-Szczepańska B., Polkowska I., Małek M., Kluczyński J., Paździor-Czapula K., Wekwejt M., Anna M., Ronowska A., Pałubicka A., Nowicka B., Otrocka-Domagała I.: The characterization of collagen‑based scaffolds modified with phenolic acids for tissue engineering application// Scientific Reports -,iss. 13 (2023), s.9966-
- DOI:
- Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1038/s41598-023-37161-6
- Źródła finansowania:
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- Nicolaus Copernicus University in Torun grant number 282/2021 IDUB SD (B.K.-S.) and the Dean of the Faculty of Civil Engineering and Geodesy of the Military University of Technology as part of grant no. UGB/22-813/2023 (M.M.).
- Weryfikacja:
- Politechnika Gdańska
wyświetlono 108 razy
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