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Environmental exposure to cadmium in breast cancer – association with the Warburg effect and sensitivity to tamoxifen

Abstrakt

The association between cadmium and breast cancer remains unexplained due to inconsistent epidemiological data and unknown underlying mechanisms. This study aimed to assess the relationship between environmental exposure to cadmium and the Warburg effect in breast cancer and, thus, its possible interference with breast cancer treatment. The observational study in two groups of breast cancer patients indicated a positive correlation between urinary cadmium concentration and tumor expression of HIF1A (a master regulator of the Warburg effect). Further explanatory research in MCF-7 cells showed no impact of cadmium exposure on molecular and biochemical markers of the Warburg effect. However, long-term exposure to a low and environmentally relevant concentration of cadmium led to the accumulation of the metal in MCF-7 cells and decreased their sensitivity to tamoxifen. To conclude, the association between cadmium and the Warburg effect was suggested in the observational study, although not confirmed in vitro. Nevertheless, cadmium seems to interfere with tamoxifen treatment which deserves further investigation in terms of its possible implication in intrinsic resistance to hormone therapy.

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Wersja publikacji
Accepted albo Published Version
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.biopha.2023.114435
Licencja
Creative Commons: CC-BY otwiera się w nowej karcie

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
BIOMEDICINE & PHARMACOTHERAPY nr 161,
ISSN: 0753-3322
Język:
angielski
Rok wydania:
2023
Opis bibliograficzny:
Tarhonska K., Janasik B., Roszak J., Kowalczyk K., Lesicka M., Reszka E., Wieczorek E., Braun M., Kolacinska-Wow A., Skokowski J., Kalinowski L., Jablonska E.: Environmental exposure to cadmium in breast cancer – association with the Warburg effect and sensitivity to tamoxifen// BIOMEDICINE & PHARMACOTHERAPY -Vol. 161, (2023), s.114435-
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.biopha.2023.114435
Źródła finansowania:
  • Narodowe Centrum Nauki, numer grantu 2016/23/D/NZ7/03645
Weryfikacja:
Politechnika Gdańska

wyświetlono 7 razy

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