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Fluorescence Imaging Using Methylene Blue Sentinel Lymph Node Biopsy in Melanoma

Abstrakt

Introduction: Fluorescence imaging of sentinel node biopsy in melanoma is a novel method. Both indocyanine green (ICG) and methylene blue (MB) have fl uorescent properties. The aim of this study was to present, for the fi rst time in a clinical series of patients, the possible usage of MB as a fl uorescent dye for sentinel node biopsy during surgery for melanoma. Material and methods: Twenty patients with skin melanoma, who were candidates for sentinel node biopsy were enrolled in our study. All patients underwent simultaneous use of standard nanocolloid and blue dye. Transcutaneous visualization of the sentinel node, visualization of lymphatic channels as well as sentinel node fl uorescent visualization were all measured. We also performed calculations of Signal to Background ratios (SBR). Results: In 15% (3/20) of patients, the fl uorescent sentinel node was visible through the skin. The median SBR for the sentinel node visualization by fl uorescence was 3.15 (range, 2.7 – 3.5). Lymphatic channels were visible in lymphatic tissue via fl uorescence before visualization by the naked eye in 4 patients (20%). The median SBR ratio was 3.69 (range, 2.7 – 4.2). Sentinel nodes were visible by fl uorescence in 13 cases (65%). The median SBR ratio was 2.49 (range, 1.5 – 5.7). No factors were found to be associated with fl uorescent MB visualization of a sentinel node during biopsy. Conclusion: This is the fi rst clinical study presenting the usefulness of fl uorescent sentinel node biopsy in melanoma patients using MB as a fl uorophore. Further studies are necessary to provide methods for its ’ clinical implementation.

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
Surgical Innovation nr 29,
ISSN: 1553-3506
Język:
angielski
Rok wydania:
2022
Opis bibliograficzny:
Cwalinski T., Skokowski J., Polom W., Marano L., Swierblewski M., Drucis K., Roviello G., Cwalina N., Kalinowski L., Roviello F., Polom K.: Fluorescence Imaging Using Methylene Blue Sentinel Lymph Node Biopsy in Melanoma// Surgical Innovation -Vol. 29,iss. 4 (2022), s.155335062210746-
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1177/15533506221074601
Źródła finansowania:
  • COST_FREE
Weryfikacja:
Politechnika Gdańska

wyświetlono 51 razy

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