Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex - Publikacja - MOST Wiedzy

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Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex

Abstrakt

Background: The aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxygenation(HbO2), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were recorded simultaneously: blood pressure, heart rate / electrocardiogram, HbO2 from right hemisphere and changes of subarachnoid space (SAS) width from left hemisphere. Signals were registered from 30 healthy, young participants (2 females and 28 males, body mass index = 24.5 ± 2.3 kg/m2, age 30.8 ± 13.4 years). Results: We analysed the recorded signals using wavelet transform and phase coherence. We demonstrated for the first time that in healthy subjects exposed to mild poikilokapnic hypoxia there were increases in very low frequency HbO2 oscillations (< 0.052 Hz) in prefrontal cortex. Additionally, SAS fluctuation diminished in the whole frequency range which could be explained by brain oedema. Conclusions: Consequently the study provides insight into mechanisms governing brain response to a mild hypoxic challenge. Our study supports the notion that HbO2 and SAS width monitoring might be beneficial for patients with acute lung disease.

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
BIOLOGICAL RESEARCH nr 54, strony 1 - 8,
ISSN: 0716-9760
Język:
angielski
Rok wydania:
2021
Opis bibliograficzny:
Gruszecka A., Waskow M., Malkiewicz M. A., Neary J., Singh J., Teckchandani T., Kratzig G., Wszedybyl-Winklewska M., Frydrychowski A. F., Rumiński J., Głowacka N., Lass P., Winklewski P., Gruszecki M.: Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex// BIOLOGICAL RESEARCH -Vol. 54, (2021), s.1-8
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1186/s40659-021-00362-2
Weryfikacja:
Politechnika Gdańska

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